関: citicoline

WordNet

a B-complex vitamin that is a constituent of lecithin; essential in the metabolism of fat

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/16 00:53:48」(JST)

wiki en

Citicoline (INN), also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is a psychostimulant/nootropic. It is an intermediate in the generation of phosphatidylcholine from choline.

Studies suggest that CDP-choline supplements increase dopamine receptor densities,^[1] and suggest that CDP-choline supplementation helps prevent memory impairment resulting from poor environmental conditions.^[2] Preliminary research has found that citicoline supplements help improve focus and mental energy and may possibly be useful in the treatment of attention deficit disorder.^[3]^[4] Citicoline has also been shown to elevate ACTH independently from CRH levels and to amplify the release of other HPA axis hormones such as LH, FSH, GH and TSH in response to hypothalamic releasing factors.^[5] These effects on HPA hormone levels may be beneficial for some individuals but may have undesirable effects in those with medical conditions featuring ACTH or cortisol hypersecretion including, but not limited to, PCOS, type II diabetes and major depressive disorder.^[6]^[7]

1 Medical uses
- 1.1 Memory disorders
- 1.2 Ischemic stroke
- 1.3 Vision
- 1.4 Satiety
2 Mechanism of action
- 2.1 Neuroprotective effects
- 2.2 Neuronal membrane
- 2.3 Cell signalling
- 2.4 Blood flow
- 2.5 Inflammation and stress
- 2.6 Glutamate transport
3 Pharmacokinetics
- 3.1 Side effects
4 Synthesis
- 4.1 In vivo
5 See also
6 References

Medical uses

Citicoline is available as a supplement online and in stores. It is sold in over 70 countries under a variety of brand names: Ceraxon, Cognizin, NeurAxon, Somazina, Synapsine, etc. When taken as a supplement citicoline is hydrolyzed into choline and cytidine in the intestine.^[8] Once these cross the blood–brain barrier it is reformed into citicoline by the rate-limiting enzyme in phosphatidylcholine synthesis, CTP-phosphocholine cytidylyltransferase.^[9]^[10]

Memory disorders

In the hippocampi of rats with induced Alzheimer's Disease, citicoline counteracts neuronal degeneration and reduces the number of apoptotic cells present. Citicoline supplementation also improves memory retention.^[9]

Ischemic stroke

Citicoline is approved for treatment in cases of head trauma, stroke, and neurodegenerative disease in Japan and Europe. Citicoline improves the clinical outcome following an ischemic stroke, as evidenced by the reduction in size of lesions caused by ischemic strokes after supplementation.^[11] It has been claimed that citicoline reduces rates of death and disability following an ischemic stroke.^[12] However, the largest trial to date, a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke in Europe, enrolling 2298 patients, found no benefit of administering citicoline on survival or recovery from stroke.^[13]

It should be noted that citicoline is the only substance that ever showed any significant neuroprotective effect at least in patients with less severe stroke events.^[14]

Vision

Citicoline improves visual function in patients with glaucoma^[15]^[16] and amblyopia^{[citation needed]}

Satiety

Cocaine dependence is associated with depleted dopamine levels in the central nervous system. In cocaine-dependent individuals citicoline increases brain dopamine levels and reduces cravings.^[17] In the general population citicoline increases brain responses to food stimuli, specifically in the amygdala, insula, and lateral orbitofrontal cortex, which correlate with decreased appetite.^[18]

Mechanism of action

Enzymes involved in reactions are identified by numbers. See file description.

Neuroprotective effects

The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelin, preservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine, partial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity. Citicoline’s effects may also be explained by the reduction of phospholipase A2 activity.^[19] Citicoline increases phosphatidylcholine synthesis.^[20]^[21]^[22] The mechanism for this may be:

By converting 1, 2-diacylglycerol into phosphatidylcholine
Stimulating the synthesis of SAMe, which aids in membrane stabilization and reduces levels of arachidonic acid. This is especially important after an ischemia, when arachidonic acid levels are elevated.^[23]

Neuronal membrane

The brain prefers to use choline to synthesize acetylcholine. This limits the amount of choline available to synthesize phosphatidylcholine. When the availability of choline is low or the need for acetylcholine increases, phospholipids containing choline can be catabolized from neuronal membranes. These phospholipids include sphingomyelin and phosphatidylcholine.^[19] Supplementation with citicoline can increase the amount of choline available for acetylcholine synthesis and aid in rebuilding membrane phospholipid stores after depletion.^[24] Citicoline decreases phospholipase stimulation. This can lower levels of hydroxyl radicals produced after an ischemia and prevent cardiolipin from being catabolized by phospholipase A2.^[25]^[26] It can also work to restore cardiolipin levels in the inner mitochondrial membrane.^[25]

Cell signalling

Citicoline enhances cellular communication by increasing the availability of neurotransmitters, including acetylcholine, norepinephrine, and dopamine.^[27]

Blood flow

Citicoline increases glucose metabolism in the brain and cerebral blood flow.^[28]

Inflammation and stress

Citicoline reduces oxidative stress. It also prevents excessive inflammatory response in the brain by inhibiting the release of free fatty acids and decreasing blood–brain barrier breakdown.^[21]

Glutamate transport

Citicoline lowers increased glutamate concentrations and raises decreased ATP concentrations induced by ischemia. Citicoline also increases glutamate uptake by increasing expression of EAAT2, a glutamate transporter, in vitro in rat astrocytes. It is suggested that the neuroprotective effects of citicoline after a stroke are due in part to citicoline’s ability to decrease levels of glutamate in the brain.^[29]

Pharmacokinetics

Citicoline is water-soluble, with more than 90% oral bioavailability.^[24] Plasma levels peak one hour after oral ingestion, and a majority of the citicoline is excreted as CO2 in respiration, and again 24 hours after ingestion, where the remaining citicoline is excreted through urine.^[30]

Side effects

Citicoline has a very low toxicity profile in animals and humans. Clinically, doses of 2000 mg per day have been observed and approved. Minor transient adverse effects are rare and most commonly include stomach pain and diarrhea.^[21]

Synthesis

In vivo

Phosphatidylcholine is a major phospholipid in eukaryotic cell membranes. Close regulation of its biosynthesis, degradation, and distribution is essential to proper cell function. phosphatidylcholine is synthesized in vivo by two pathways

The Kennedy pathway, which includes the transformation of choline to citicoline, by way of phosphorylcholine, to produce phosphatidylcholine when condensed with diacylglycerol.
Phosphatidylcholine can also be produced by the methylation pathway, where phosphatidylethanolamine is sequentially methylated.^[31]

References

^ Giménez R, Raïch J, Aguilar J (Nov 1991). "Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice". British Journal of Pharmacology 104 (3): 575–8. doi:10.1111/j.1476-5381.1991.tb12471.x. PMC 1908237. PMID 1839138.
^ Teather LA, Wurtman RJ (2005). "Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats". Learning & Memory 12 (1): 39–43. doi:10.1101/lm.83905. PMC 548494. PMID 15647594.
^ "Supplement naturally boosts ageing brain power". Sydney Morning Herald. 2008-02-25. Retrieved 2009-07-28.
^ Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA (Nov 2008). "Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy". NMR in Biomedicine 21 (10): 1066–75. doi:10.1002/nbm.1281. PMID 18816480.
^ Cavun S, Savci V (Oct 2004). "CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement". Fundamental & Clinical Pharmacology 18 (5): 513–23. doi:10.1111/j.1472-8206.2004.00272.x. PMID 15482372.
^ Benson S, Arck PC, Tan S, Hahn S, Mann K, Rifaie N, Janssen OE, Schedlowski M, Elsenbruch S (Jun 2009). "Disturbed stress responses in women with polycystic ovary syndrome". Psychoneuroendocrinology 34 (5): 727–35. doi:10.1016/j.psyneuen.2008.12.001. PMID 19150179.
^ Florio P, Zatelli MC, Reis FM, degli Uberti EC, Petraglia F (2007). "Corticotropin releasing hormone: a diagnostic marker for behavioral and reproductive disorders?". Frontiers in Bioscience 12: 551–60. doi:10.2741/2081. PMID 17127316.
^ Wurtman RJ, Regan M, Ulus I, Yu L (Oct 2000). "Effect of oral CDP-choline on plasma choline and uridine levels in humans". Biochemical Pharmacology 60 (7): 989–92. doi:10.1016/S0006-2952(00)00436-6. PMID 10974208.
^ ^a ^b Alvarez XA, Sampedro C, Lozano R, Cacabelos R (Oct 1999). "Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats". Methods and Findings in Experimental and Clinical Pharmacology 21 (8): 535–40. doi:10.1358/mf.1999.21.8.794835. PMID 10599052.
^ Carlezon WA, Pliakas AM, Parow AM, Detke MJ, Cohen BM, Renshaw PF (Jun 2002). "Antidepressant-like effects of cytidine in the forced swim test in rats". Biological Psychiatry 51 (11): 882–9. doi:10.1016/s0006-3223(01)01344-0. PMID 12022961.
^ Warach S, Pettigrew LC, Dashe JF, Pullicino P, Lefkowitz DM, Sabounjian L, Harnett K, Schwiderski U, Gammans R (Nov 2000). "Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators". Annals of Neurology 48 (5): 713–22. doi:10.1002/1531-8249(200011)48:5<713::aid-ana4>3.0.co;2-#. PMID 11079534.
^ Saver JL (Fall 2008). "Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair". Reviews in Neurological Diseases 5 (4): 167–77. PMID 19122569.
^ Dávalos A, Alvarez-Sabín J, Castillo J, Díez-Tejedor E, Ferro J, Martínez-Vila E, Serena J, Segura T, Cruz VT, Masjuan J, Cobo E, Secades JJ (Jul 2012). "Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)". Lancet 380 (9839). doi:10.1016/S0140-6736(12)60813-7. PMID 22691567.
^ Overgaard K (Aug 2014). "The effects of citicoline on acute ischemic stroke: a review". Journal of Stroke and Cerebrovascular Diseases 23 (7): 1764–9. doi:10.1016/j.jstrokecerebrovasdis.2014.01.020. PMID 24739589.
^ Parisi V, Coppola G, Centofanti M, Oddone F, Angrisani AM, Ziccardi L, Ricci B, Quaranta L, Manni G (2008). "Evidence of the neuroprotective role of citicoline in glaucoma patients". Progress in Brain Research 173: 541–54. doi:10.1016/S0079-6123(08)01137-0. PMID 18929133.
^ Parisi V, Coppola G, Ziccardi L, Gallinaro G, Falsini B (May 2008). "Cytidine-5'-diphosphocholine (Citicoline): a pilot study in patients with non-arteritic ischaemic optic neuropathy". European Journal of Neurology 15 (5): 465–474. doi:10.1111/j.1468-1331.2008.02099.x. PMID 18325025.
^ Renshaw PF, Daniels S, Lundahl LH, Rogers V, Lukas SE (Feb 1999). "Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects: a preliminary report". Psychopharmacology 142 (2): 132–8. doi:10.1007/s002130050871. PMID 10102764.
^ Killgore WD, Ross AJ, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA (Jan 2010). "Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods". The International Journal of Eating Disorders 43 (1): 6–13. doi:10.1002/eat.20658. PMC 3378241. PMID 19260039.
^ ^a ^b Adibhatla RM, Hatcher JF, Dempsey RJ (Jan 2002). "Citicoline: neuroprotective mechanisms in cerebral ischemia". Journal of Neurochemistry 80 (1): 12–23. doi:10.1046/j.0022-3042.2001.00697.x. PMID 11796739.
^ López-Coviella I, Agut J, Savci V, Ortiz JA, Wurtman RJ (Aug 1995). "Evidence that 5'-cytidinediphosphocholine can affect brain phospholipid composition by increasing choline and cytidine plasma levels". Journal of Neurochemistry 65 (2): 889–94. doi:10.1046/j.1471-4159.1995.65020889.x. PMID 7616250.
^ ^a ^b ^c Conant R, Schauss AG (Mar 2004). "Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature". Alternative Medicine Review 9 (1): 17–31. PMID 15005642.
^ Babb SM, Wald LL, Cohen BM, Villafuerte RA, Gruber SA, Yurgelun-Todd DA, Renshaw PF (May 2002). "Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study". Psychopharmacology 161 (3): 248–54. doi:10.1007/s00213-002-1045-y. PMID 12021827.
^ Rao AM, Hatcher JF, Dempsey RJ (Dec 1999). "CDP-choline: neuroprotection in transient forebrain ischemia of gerbils". Journal of Neuroscience Research 58 (5): 697–705. doi:10.1002/(sici)1097-4547(19991201)58:5<697::aid-jnr11>3.0.co;2-b. PMID 10561698.
^ ^a ^b D'Orlando KJ, Sandage BW (Aug 1995). "Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury". Neurological Research 17 (4): 281–4. PMID 7477743.
^ ^a ^b Rao AM, Hatcher JF, Dempsey RJ (Mar 2001). "Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?". Brain Research 893 (1-2): 268–72. doi:10.1016/S0006-8993(00)03280-7. PMID 11223016.
^ Adibhatla RM, Hatcher JF (Aug 2003). "Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia". Journal of Neuroscience Research 73 (3): 308–15. doi:10.1002/jnr.10672. PMID 12868064.
^ Secades JJ, Lorenzo JL (Sep 2006). "Citicoline: pharmacological and clinical review, 2006 update". Methods and Findings in Experimental and Clinical Pharmacology. 28 Suppl B: 1–56. PMID 17171187.
^ Watanabe S, Kono S, Nakashima Y, Mitsunobu K, Otsuki S (1975). "Effects of various cerebral metabolic activators on glucose metabolism of brain". Folia Psychiatrica Et Neurologica Japonica 29 (1): 67–76. PMID 1098982.
^ Hurtado O, Moro MA, Cárdenas A, Sánchez V, Fernández-Tomé P, Leza JC, Lorenzo P, Secades JJ, Lozano R, Dávalos A, Castillo J, Lizasoain I (Mar 2005). "Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport". Neurobiology of Disease 18 (2): 336–345. doi:10.1016/j.nbd.2004.10.006. PMID 15686962.
^ Dinsdale JR, Griffiths GK, Rowlands C, Castelló J, Ortiz JA, Maddock J, Aylward M (1983). "Pharmacokinetics of 14C CDP-choline". Arzneimittel-Forschung 33 (7A): 1066–70. PMID 6412727.
^ Fernández-Murray JP, McMaster CR (Nov 2005). "Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway". The Journal of Biological Chemistry 280 (46): 38290–6. doi:10.1074/jbc.M507700200. PMID 16172116.

UpToDate Contents

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English Journal

Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy.

Yamamoto GL1, Baratela WA2, Almeida TF2, Lazar M3, Afonso CL4, Oyamada MK4, Suzuki L5, Oliveira LA5, Ramos ES6, Kim CA2, Passos-Bueno MR3, Bertola DR7.Author information 1Unidade de Genética, Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, Brazil; Centro de Estudos do Genoma Humano, Instituto de Biociências da Universidade de São Paulo, São Paulo 05508-090, Brazil. Electronic address: guilherme.yamamoto@usp.br.2Unidade de Genética, Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, Brazil.3Centro de Estudos do Genoma Humano, Instituto de Biociências da Universidade de São Paulo, São Paulo 05508-090, Brazil.4Departamento de Oftalmologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, Brazil.5Departamento de Radiologia, Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, Brazil.6Departamento de Genética, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto 14049-900, Brazil.7Unidade de Genética, Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, Brazil; Centro de Estudos do Genoma Humano, Instituto de Biociências da Universidade de São Paulo, São Paulo 05508-090, Brazil.AbstractSpondylometaphyseal dysplasia with cone-rod dystrophy is a rare autosomal-recessive disorder characterized by severe short stature, progressive lower-limb bowing, flattened vertebral bodies, metaphyseal involvement, and visual impairment caused by cone-rod dystrophy. Whole-exome sequencing of four individuals affected by this disorder from two Brazilian families identified two previously unreported homozygous mutations in PCYT1A. This gene encodes the alpha isoform of the phosphate cytidylyltransferase 1 choline enzyme, which is responsible for converting phosphocholine into cytidine diphosphate-choline, a key intermediate step in the phosphatidylcholine biosynthesis pathway. A different enzymatic defect in this pathway has been previously associated with a muscular dystrophy with mitochondrial structural abnormalities that does not have cartilage and/or bone or retinal involvement. Thus, the deregulation of the phosphatidylcholine pathway may play a role in multiple genetic diseases in humans, and further studies are necessary to uncover its precise pathogenic mechanisms and the entirety of its phenotypic spectrum.
American journal of human genetics.Am J Hum Genet.2014 Jan 2;94(1):113-9. doi: 10.1016/j.ajhg.2013.11.022.
Spondylometaphyseal dysplasia with cone-rod dystrophy is a rare autosomal-recessive disorder characterized by severe short stature, progressive lower-limb bowing, flattened vertebral bodies, metaphyseal involvement, and visual impairment caused by cone-rod dystrophy. Whole-exome sequencing of four i
PMID 24387991

Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility.

Cebrián A1, Taron M, Sala N, Ardanaz E, Chirlaque MD, Larrañaga N, Redondo ML, Sánchez MJ, Gómez del Pulgar T, Camps C, Rosell R, González CA, Lacal JC.Author information 1Division of Translational Oncology, Health Research Institute and University Hospital Fundación Jiménez Díaz, Madrid, Spain, arancha.cebrian@fjd.es.AbstractAIM: The relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case-control association study if genetics variants in these pathways are associated with risk of developing lung cancer.
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PMID 23896864

Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: The influence of LCPUFA on neural development, aging, and neurodegeneration.

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Progress in lipid research.Prog Lipid Res.2014 Jan;53:1-17. doi: 10.1016/j.plipres.2013.10.002. Epub 2013 Oct 24.
Many clinical and animal studies demonstrate the importance of long-chain polyunsaturated fatty acids (LCPUFA) in neural development and neurodegeneration. This review will focus on involvement of LCPUFA from genesis to senescence. The LCPUFA docosahexaenoic acid and arachidonic acid are important c
PMID 24334113

Japanese Journal

Construction of a Plasmid Carrying both CTP Synthetase and a Fused Gene Formed from Cholinephosphate Cytidylyltransferase and Choline Kinase Genes and Its Application to Industrial CDP-Choline Production : Enzymatic Production of CDP-Choline from Orotic Acid (Part II)

Fujio Tatsuro,Teshiba Sadao,Maruyama Akihiko,,,
Bioscience, biotechnology, and biochemistry 61(6), 960-964, 1997-06-23
… A new method for enzymatic production of cytidine diphosphate choline (CDP-choline) from orotic acid and choline chloride was developed. … coli, cholinephosphate cytidylyltransferase (encoded by the CCT gene from Saccharomyces cerevisiae), and choline kinase (encoded by the CKI gene from S. …
NAID 110002678619

Enzymatic Production of Pyrimidine Nucleotides Using Corynebacterium ammoniagenes Cells and Recombinant Escherichia coli Cells : Enzymatic Production of CDP-Choline from Orotic Acid and Choline Chloride (Part I)

Fujio Tatsuro,Maruyama Akihiko,,
Bioscience, biotechnology, and biochemistry 61(6), 956-959, 1997-06-23
… Enzymatic production of cytidine diphosphate choline (CDP-choline) using orotic acid and choline chloride as substrates was investigated using a 200-ml beaker as a reaction vessel. … In this reaction, UDP and UTP were also accumulated, but CTP, a direct precursor of CDP-choline, was not accumulated sufficiently. … To produce CDP-choline, two additional enzyme activities were needed. …
NAID 110002678618

新リン酸化剤MTBOを用いる補酵素Cytidine Diphosphate Cholineの合成

江藤正義 [他]
姫路短期大学研究報告 (26), p129-133, 1981-01-00
NAID 40003272652

Related Pictures

★リンクテーブル★

リンク元	「シチコリン」「citicoline」「シチジン二リン酸コリン」
関連記事	「diphosphate」

「シチコリン」

Citicoline
Systematic (IUPAC) name
	5'-O-[hydroxy({hydroxy[2-(trimethylammonio)ethoxy]; phosphoryl}oxy)phosphoryl]cytidine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	987-78-0
ATC code	N06BX06
PubChem	CID: 11583971
ChemSpider	13207
UNII	536BQ2JVC7
KEGG	D00057
ChEBI	CHEBI:16436
ChEMBL	CHEMBL1618340
Synonyms	Cytidine diphosphate choline
Chemical data
Formula	C14H27N4O11P2+
Molecular mass	489.332 g/mol
	SMILES C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=NC2=O)N)O)O ;
	InChI InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 ; Key:RZZPDXZPRHQOCG-OJAKKHQRSA-N ;
(what is this?) (verify)

　　[★]

英: citicoline
同: シチジン二リン酸コリン cytidine diphosphate choline CDP-choline
商: シスコリン、シチコリンH、シチコリン、ニコリンH、ニコリン、レコグナンS、レコグナン; エンサイン、オーデス、ニコリン、ノイコリス、プルベ、レコグナン
関: その他の循環器官用薬

脳代謝改善薬

膵炎治療薬

細胞膜成分生合成阻害薬

「citicoline」

　　[★] シチコリン

関: citicoline sodium、cytidine diphosphate choline

「シチジン二リン酸コリン」

　　[★]

英: cytidine diphosphate choline
関: シチコリン

「diphosphate」

　　[★] 二リン酸エステル、二リン酸塩、二リン酸

関: bisphosphate、diphosphoric acid、pyrophosphate

[1] Giménez R, Raïch J, Aguilar J (Nov 1991). "Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice". British Journal of Pharmacology 104 (3): 575–8. doi:10.1111/j.1476-5381.1991.tb12471.x. PMC 1908237. PMID 1839138.

[2] Teather LA, Wurtman RJ (2005). "Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats". Learning & Memory 12 (1): 39–43. doi:10.1101/lm.83905. PMC 548494. PMID 15647594.

[3] "Supplement naturally boosts ageing brain power". Sydney Morning Herald. 2008-02-25. Retrieved 2009-07-28.

[4] Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA (Nov 2008). "Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy". NMR in Biomedicine 21 (10): 1066–75. doi:10.1002/nbm.1281. PMID 18816480.

[5] Cavun S, Savci V (Oct 2004). "CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement". Fundamental & Clinical Pharmacology 18 (5): 513–23. doi:10.1111/j.1472-8206.2004.00272.x. PMID 15482372.

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cytidine diphosphate choline