WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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[Vegetative state treated with acupoint injection combined with plum-blossom needle in children: a randomized controlled trial].

Tang Y, Shang Q, Zhou LH.
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.Zhongguo Zhen Jiu.2014 May;34(5):421-5.
OBJECTIVE: To observe the clinical efficacy difference on vegetative state in children between acupoint injection combined with plum-blossom needle and western medication based on basic treatment.METHODS: Forty-eight children of vegetative state were randomized into an observation group and a contro
PMID 25022107

Development and Validation of Reverse-phase High-performance Liquid Chromatography Method for Estimation of Citicoline Sodium in Bulk and Dosage Form.

Maradiya HK1, Pansara VH.
Indian journal of pharmaceutical sciences.Indian J Pharm Sci.2013 Mar;75(2):238-41.
A simple, accurate, precise and sensitive reverse-phase high-performance liquid chromatography method for the determination of citicoline sodium has been developed and validated. Drug was resolved on a C18 column (Phenomenex Luna, 250×4.6 mm, 10μ), utilizing mobile phase of potassium dihydrogen ph
PMID 24019577

Zhang LN1, Sun YJ, Pan S, Li JX, Qu YE, Li Y, Wang YL, Gao ZB.
Fundamental & clinical pharmacology.Fundam Clin Pharmacol.2013 Feb;27(1):96-103. doi: 10.1111/fcp.12000. Epub 2012 Oct 3.
Alzheimer disease (AD) is a neurodegenerative disorder clinically characterized by progressive cognitive and memory dysfunction, which is the most common form of dementia. Although the pathogenesis of neuronal injury in AD is not clear, recent evidences suggest that Na⁺-K⁺-ATPase plays an import
PMID 23033963

Application of 4-Hydroxyantipyrine and Acetaminophen O-Sulfate as Biodistribution Promoter

OHKAWA Yuhsuke,KIYOHARA Yasunori,ASOH Tomoyuki,MAEDA Hiroshi,KURUMI Masateru,SASAKI Kenji,KUROSAKI Yuhji,MATSUMURU Miki,NAKAYAMA Taiji
Biological & pharmaceutical bulletin 24(12), 1404-1410, 2001-12-01
… The effects of 4-hydroxyantipyrine(4-OH), a major metabolite of antipyrine and its sulfate, 4-hydroxyantipyrine O-sulfate(4-S), on the pharmacokinetics of citicoline and thiopental sodium were investigated in rats. … The concomitant use of 4-OH increased significantly the tissue-to-plasma concentration ratio(K_p)of citicoline in the brain and liver and that of thiopental sodium in the brain, liver, and heart, while 4-S did not affect them. …
NAID 110003638429

村松修吾
病院薬学 2(3), 174-177, 1976-11-20
… The thin-layer chromatography is convenient to determine the decomposed products of citicoline preparation. … The plates were developed by the ascending technique with the solvent system, acetone-M-sodium actate-35% ammonium sulfate-ethylacetate (20 : 20 : 3 : 3, v/v). … Citicoline and its products on chromatogram was visualized under short-wave ultraviolet rays. …
NAID 110001796635