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1. 遺伝性疾患の基本原則 basic principles of genetic disease
2. 分子遺伝学の原理 principles of molecular genetics
3. DNA父子鑑定検査 paternity testing using dna
4. 次世代DNAシークエンシングの原理および臨床応用 principles and clinical applications of next generation dna sequencing
5. 遺伝的変異の概要 overview of genetic variation

A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex.

Lim CT1, Lai PJ1, Leach DR2, Maki H1, Furukohri A3.
Nucleic acids research.Nucleic Acids Res.2015 Nov 16;43(20):9804-16. doi: 10.1093/nar/gkv855. Epub 2015 Aug 28.
The Mre11/Rad50 complex is a central player in various genome maintenance pathways. Here, we report a novel mode of nuclease action found for the Escherichia coli Mre11/Rad50 complex, SbcC2/D2 complex (SbcCD). SbcCD cuts off the top of a cruciform DNA by making incisions on both strands and continue
PMID 26319016

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift.

Torregrosa-Muñumer R1, Goffart S1, Haikonen JA1, Pohjoismäki JL2.
Molecular biology of the cell.Mol Biol Cell.2015 Nov 15;26(23):4197-208. doi: 10.1091/mbc.E15-06-0390. Epub 2015 Sep 23.
Mitochondrial DNA is prone to damage by various intrinsic as well as environmental stressors. DNA damage can in turn cause problems for replication, resulting in replication stalling and double-strand breaks, which are suspected to be the leading cause of pathological mtDNA rearrangements. In this s
PMID 26399294

Heather JM1, Chain B2.
Genomics.Genomics.2015 Nov 10. pii: S0888-7543(15)30041-0. doi: 10.1016/j.ygeno.2015.11.003. [Epub ahead of print]
Determining the order of nucleic acid residues in biological samples is an integral component of a wide variety of research applications. Over the last fifty years large numbers of researchers have applied themselves to the production of techniques and technologies to facilitate this feat, sequencin
PMID 26554401