コンディショナルノックアウトの

WordNet

establish a conditioned response
the state of (good) health (especially in the phrases `in condition or `in shape or `out of condition or `out of shape' (同)shape
a state at a particular time; "a condition (or state) of disrepair"; "the current status of the arms negotiations" (同)status
a mode of being or form of existence of a person or thing; "the human condition"
an illness, disease, or other medical problem; "a heart condition"; "a skin condition"
apply conditioner to in order to make smooth and shiny; "I condition my hair after washing it"
put into a better state; "he conditions old cars"
the procedure that is varied in order to estimate a variables effect by comparison with a control condition (同)experimental_condition
an assumption on which rests the validity or effect of something else (同)precondition, stipulation
(usually plural) a statement of what is required as part of an agreement; "the contract set out the conditions of the lease"; "the terms of the treaty were generous" (同)term
qualified by reservations
imposing or depending on or containing a condition; "conditional acceptance of the terms"; "lent conditional support"; "the conditional sale will not be complete until the full purchase price is paid"
a blow that renders the opponent unconscious (同)KO, kayo

PrepTutorEJDIC

〈U〉(事物の)『状態』;(人の)健康状態 / 〈C〉《通例複数形で》(周囲の)『状況』,事情,形勢 / 〈C〉(…の)条件,必要条件《+『of』(『for』)+『名』》;(条件を示す)条項 / 〈C〉(社会的)地位,身分,境遇 / 〈C〉(慢性の)病気,症状 / (…に備えて)〈体など〉'を'『適当な状態にする』,‘の'調子を整える《+『名』+『for』+『名』》 / 〈物事が〉…‘の'条件となる,…を左右する,決定する / 〈人・動物など〉'を'慣らす,適応させる
条件つきの,暫定的な / (文法で)条件を表す / (文法で)条件文(節)
(ボクシングの)ノックアウト(《略》『KO,K.O.,k.o.』) / 《話》すばらしい人(物) / ノックアウトする

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Conrad M1, Ingold I2, Buday K2, Kobayashi S3, Angeli JP2.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Aug;1850(8):1566-1574. doi: 10.1016/j.bbagen.2014.10.020. Epub 2014 Oct 23.
BACKGROUND: During maturation and storage, spermatozoa generate substantial amounts of reactive oxygen species (ROS) and are thus forced to cope with an increasingly oxidative environment that is both needed and detrimental to their biology. Such a janus-faceted intermediate needs to be tightly cont
PMID 25450170

mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration.

Zhang P1, Liang X2, Shan T2, Jiang Q3, Deng C4, Zheng R5, Kuang S6.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Jul 17;463(1-2):102-8. doi: 10.1016/j.bbrc.2015.05.032. Epub 2015 May 18.
The serine/threonine kinase mammalian target of rapamycin (mTOR) is a key regulator of protein synthesis, cell proliferation and energy metabolism. As constitutive deletion of Mtor gene results in embryonic lethality, the function of mTOR in muscle stem cells (satellite cells) and skeletal muscle re
PMID 25998386

Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation.

Zhang J1, Taylor RJ2, La Torre A2, Wilken MS3, Cox KE2, Reh TA2, Vetter ML4.
Developmental biology.Dev Biol.2015 Jul 15;403(2):128-38. doi: 10.1016/j.ydbio.2015.05.010. Epub 2015 May 16.
Epigenetic regulation, including histone modification, is a critical component of gene regulation, although precisely how this contributes to the development of complex tissues such as the neural retina is still being explored. We show that during retinal development in mouse, there are dynamic patt
PMID 25989023

FLASH/casp8ap2 Is Indispensable for Early Embryogenesis but Dispensable for Proliferation and Differentiation of ES Cells

Minamida Yoshitaka,Someda Masataka,Yonehara Shin
PLoS ONE 9(9), 2014-09-19
… We here demonstrated that the induced knockout of FLASH never affected cell cycle progression in ES cells, in which the expression of core histone genes was decreased to levels similar to those in human KB cells sensitive to the knockdown of FLASH. … In addition, the FLASH conditional knockout ES cells could differentiate normally into not only mesodermal and endodermal cells, but also trophoblasts. …
NAID 120005496633

Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells

Ueyama Takehiko,Sakaguchi Hirofumi,Nakamura Takashi,Goto Akihiro,Morioka Shigefumi,Shimizu Aya,Nakao Kazuki,Hishikawa Yoshitaka,Ninoyu Yuzuru,Kassai Hidetoshi,Suetsugu Shiro,Koji Takehiko,Fritzsch Bernd,Yonemura Shigenobu,Hisa Yasuo,Matsuda Michiyuki,Aiba Atsu,Saito Naoaki
Journal of Cell Science 127(9), 2040-2052, 2014-05
… We employed inner ear hair-cell-specific conditional knockout to analyze the role of Cdc42 in hair cells possessing highly elaborate stable actin protrusions (stereocilia). …
NAID 120005439020

山下雄也,郭伸
臨床神経学 54(12), 1151-1154, 2014
ALSの病理学的指標であるTDP-43病理の形成メカニズムは未解明であり，引き金になるTDP-43の易凝集性断片形成に関与するプロテアーゼやその活性化メカニズムに関する合理的な説明はなかった．われわれは，孤発性ALSのもう一つの疾患特異的分子変化である，RNA編集酵素ADAR2の発現低下を再現するALSの分子病態モデルマウスの解析から，異常なCa2+透過性AMPA受容体発現を介したカルパインの活性 …
NAID 130004921169