cleavage stimulation factor

切断刺激因子、切断促進因子

関

CstF

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. (embryology) the repeated division of a fertilised ovum (同)segmentation
8. the breaking of a chemical bond in a molecule resulting in smaller molecules
9. the state of being split or cleft; "there was a cleavage between the liberal and conservative members"
10. the act of cleaving or splitting
11. the line formed by a groove between two parts (especially the separation between a womans breasts)
12. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
13. a concept whose truth can be proved; "scientific hypotheses are not facts"
14. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
15. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
16. (physiology) the effect of a stimulus (on nerves or organs etc.)
17. the act of arousing an organism to action
18. any stimulating information or event; acts to arouse action (同)stimulus, stimulant, input

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 割る(割れる)こと;割れ(裂け)目 / 卵割(受精卵の細胞分裂) / (鉱物の結晶の)劈開(へきかい) / 《話》(大きなえりぐりのドレスから見える)乳房の谷間
3. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
4. 刺激,興奮;激励

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/14 13:59:21」(JST)

wiki en

[Wiki en表示]

Cleavage stimulatory factor or cleavage stimulation factor (CstF or CStF) is a heterotrimeric protein, made up of the proteins CSTF1 (55kDa), CSTF2 (64kDa) and CSTF3 (77kDa), totalling about 200 kDa. It is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (mRNA) molecule. CstF is recruited by cleavage and polyadenylation specificity factor (CPSF) and assembles into a protein complex on the 3' end to promote the synthesis of a functional polyadenine tail, which results in a mature mRNA molecule ready to be exported from the cell nucleus to the cytosol for translation.

The amount of CstF in a cell is dependent on the phase of the cell cycle, increasing significantly during the transition from G0 phase to S phase in mouse fibroblast and human splenic B cells.

Genes

• CSTF1, CSTF2, CSTF3

References

Further reading

• Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. (2004). Molecular Cell Biology. WH Freeman: New York, NY. 5th ed.

External links

• Cleavage+stimulation+factor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 血友病患者における第VIIIおよび第IX因子阻害物質 factor viii and factor ix inhibitors in patients with hemophilia
• 2. 直接トロンビン阻害剤および直接Xa因子阻害剤による抗凝固療法 anticoagulation with direct thrombin inhibitors and direct factor xa inhibitors
• 3. 止血の概要 overview of hemostasis
• 4. 第V因子ライデンおよび活性化プロテインC抵抗性：臨床症状および診断 factor v leiden and activated protein c resistance clinical manifestations and diagnosis
• 5. von Willebrand因子の生物学および正常機能 biology and normal function of von willebrand factor

English Journal

• 3'UTR shortening and EGF signaling: implications for breast cancer.

• Akman HB1, Oyken M1, Tuncer T1, Can T2, Erson-Bensan AE3.
• Human molecular genetics.Hum Mol Genet.2015 Dec 15;24(24):6910-20. doi: 10.1093/hmg/ddv391. Epub 2015 Sep 22.
• Alternative polyadenylation (APA) plays a role in gene expression regulation generally by shortening of 3'UTRs (untranslated regions) upon proliferative signals and relieving microRNA-mediated repression. Owing to high proliferative indices of triple negative breast cancers (TNBCs), we hypothesized
• PMID 26395459

• Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone.

• Clifton KB1, Conover CA2.
• Bone.Bone.2015 Dec;81:413-6. doi: 10.1016/j.bone.2015.08.015. Epub 2015 Aug 20.
• Intermittent parathyroid hormone (PTH) is a potent anabolic therapy for bone, and several studies have implicated local insulin-like growth factor (IGF) signaling in mediating this effect. The IGF system is complex and includes ligands and receptors, as well as IGF binding proteins (IGFBPs) and IGFB
• PMID 26297833

• A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells.

• Derer S1, Cossham M2, Rösner T2, Kellner C2, Beurskens FJ3, Schwanbeck R2, Lohse S4, Sina C5, Peipp M2, Valerius T2.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Nov 15;195(10):5077-87. doi: 10.4049/jimmunol.1501458. Epub 2015 Oct 16.
• Complement-dependent cytotoxicity (CDC) has been suggested to be an important mechanism of action of tumor-targeting Abs. However, single unmodified epidermal growth factor receptor (EGFR)-targeting IgG1 Abs fail to trigger efficient CDC. For the current study, we generated a CDC-optimized variant o
• PMID 26475927

Japanese Journal

• The Release of EGF Domain from EGF-like Factors by a Specific Cleavage Enzyme Activates the EGFR-MAPK3/1 Pathway in Both Granulosa Cells and Cumulus Cells During the Ovulation Process

• YAMASHITA Yasuhisa,SHIMADA Masayuki
• Journal of Reproduction and Development 58(5), 510-514, 2012
• … In mammalian preovulatory follicles, LH stimulation induces the ovulation process, including follicular wall rupture, granulosa cell luteinization, cumulus cell expansion and meiotic maturation of the oocyte. … Thus, a potent factor(s) secreted by granulosa cells is required to stimulate not only granulosa cells via an autocrine manner but also cumulus cells and/or oocytes via a paracrine pathway. …
• NAID 130001854995

• Influence of Adipocytokines on Differentiation of Pro-osteoblastic Cells

• KAMADA Aiko,IKEO Takashi,YOSHIKAWA Yoshihiro,DOMAE Eisuke,GODA Seiji,TAMURA Isao,KON-I Hirotaka,OKAZAKI Joji,KAWAMOTO Akiyo,KOMASA Yutaka,TODA Isumi,SUWA Fumihiko
• Journal of oral tissue engineering 6(1), 17-23, 2008-09-30
• … Adipocytokines are a group of adipocyte-derived biologically active molecules, including adiponectin, leptin, tumor necrosis factor-α (TNF-α), resistin. … A proteolytic cleavage product of adiponectin/Acrp30, gAcrp30, is found to circulate in plasma and to have a three-dimensional structure similar to that of TNF-α. …
• NAID 110007004835

• ブドウ球菌性乳房炎においてエラスターゼにより分解されたウシ・ラクトフェリン(Lf)の炎症効果(内科学)

• 小峯 優美子,黒石 智誠,小林 仁 [他],麻生 久,小原 嘉昭,熊谷 勝男,菅原 俊二,小峯 健一
• The journal of veterinary medical science 68(7), 715-723, 2006-07-25
• … は,elastase-LfとCon A低親和性Lfに共通する4つのペプチドを確認し,合成ペプチドを作成した.その結果,elastase-Lf,Con A低親和性Lfおよび合成ペプチドのGQRDLLFKDSALによる刺激倍増により,乳腺上皮株化細胞(BMEC)で,nuclear factor kappa B(NFκB)の活性化に基づくIL-6,TNFα,IL-8およびMCP-1の強いmRNAの発現が誘導された.以上の結果から,ブドウ球菌性乳房炎において,Lfがエラスターゼにより分解され,Lfの生理作用が変化することが示唆された.また …
• NAID 110004763181

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★リンクテーブル★

リンク元	「切断刺激因子」「切断促進因子」「CstF」
関連記事	「cleavage」「fact」「factor」「stimulation」

「切断刺激因子」

　　[★]

英

cleavage stimulation factor、CstF

関

切断促進因子

「切断促進因子」

　　[★]

英

cleavage stimulation factor

関

切断刺激因子

「CstF」

　　[★]

• 切断刺激因子

関

cleavage stimulation factor

「cleavage」

　　[★]

• n.

• 裂けること、裂開、分割。(政党などの)分裂(between)
• (襟ぐりの深いドレスであらわになった)女性の乳房の間のくぼみ、乳房の谷間
• 劈開
• 劈開面
• (受精卵の)卵割

　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「stimulation」

　　[★]

• n.

• 刺激、刺激作用