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a yellow crystalline antibiotic (trade name Aureomycin) used to treat certain bacterial and rickettsial diseases (同)Aureomycin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/17 07:50:50」(JST)

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Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 by Benjamin Minge Duggar working at Lederle Laboratories under the supervision of Yellapragada Subbarow. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.^[1] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.

In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.^[2]

References

^ Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
^ Merck Veterinary Manual.

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UpToDate Contents

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1. テトラサイクリン tetracyclines
2. リケッチア痘瘡 rickettsialpox

English Journal

DNA damage and biochemical toxicity of antibiotics in soil on the earthworm Eisenia fetida.

Dong L, Gao J, Xie X, Zhou Q.SourceKey Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China; Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China.
Chemosphere.Chemosphere.2012 Sep;89(1):44-51. Epub 2012 May 28.
DNA damage and changes in enzyme activities were used as biomarkers to evaluate the genotoxicity and oxidative stress of tetracycline and chlortetracycline on the earthworm Eisenia fetida. The results showed that both antibiotics induced significant genotoxicity on earthworms in a dose-dependent man
PMID 22647195

Degradation and toxicity assessment of sulfamethoxazole and chlortetracycline using electron beam, ozone and UV.

Kim TH, Kim SD, Kim HY, Lim SJ, Lee M, Yu S.SourceDepartment of Environmental Science and Engineering, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Buk-gu, Gwangju 500-712, Republic of Korea; Research Division for Industry and Environment, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Republic of Korea.
Journal of hazardous materials.J Hazard Mater.2012 Aug 15;227-228:237-42. Epub 2012 May 28.
Recently, the occurrence of antibiotics in sewage treatment plant effluent, as well as drinking water, has raised concern about their potential impacts on the environment and public health. Antibiotics are found in surface and ground waters, which indicate their ineffective removal by conventional w
PMID 22682797

Japanese Journal

LC-MS/MSによる水環境試料中のテトラサイクリン系抗生物質及びその代謝物の定量

分析化学 64(1), 25-34, 2015
NAID 130004732534

<i>In Vitro</i> Susceptibility of <i>Mycoplasma hyopneumoniae</i> Field Isolates and Occurrence of Fluoroquinolone, Macrolides and Lincomycin Resistance

Journal of Veterinary Medical Science 75(8), 1067-1070, 2013
NAID 130003362167

Treatment of tetracycline antibiotics by laccase in the presence of 1-hydroxybenzotriazole

Bioresource technology 103(1), 498-501, 2011-10-20
NAID 120003535063

Related Pictures

★リンクテーブル★

リンク元	「テトラサイクリン系抗菌薬」「クロルテトラサイクリン」
拡張検索	「chlortetracycline bisulfate」「chlortetracycline hydrochloride」「demethylchlortetracycline hydrochloride」「demethylchlortetracycline」

「テトラサイクリン系抗菌薬」

Chlortetracycline
Systematic (IUPAC) name
	(4S,4aS,5aS,6S,12aS,Z)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydrotetracene-1,3,12(2H,4H,12aH)-trione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Oral, IV, topical
Pharmacokinetic data
Bioavailability	30%
Protein binding	50 to 55%
Metabolism	Hepatic (75%)
Biological half-life	5.6 to 9 hours
Excretion	Renal and biliary
Identifiers
CAS Number	57-62-5
ATC code	A01AB21 D06AA02 J01AA03 S01AA02 QG51AA08 QJ51AA03
ChemSpider	10469370
UNII	WCK1KIQ23Q
KEGG	D07689
ChEMBL	CHEMBL456066
Chemical data
Formula	C22H23ClN2O8
Molar mass	478.88 g/mol
	SMILES CN(C)[C@@H]2C(\O)=C(\C(N)=O)C(=O)[C@@]3(O)C(/O)=C4/C(=O)c1c(O)ccc(Cl)c1[C@@](C)(O)[C@H]4C[C@@H]23 ;
	InChI InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1 ; Key:CYDMQBQPVICBEU-XRNKAMNCSA-N ;
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