- 関
- chlortetracycline、chlortetracycline bisulfate
WordNet
- a yellow crystalline antibiotic (trade name Aureomycin) used to treat certain bacterial and rickettsial diseases (同)Aureomycin
- a complex consisting of an organic base in association with hydrogen chloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/03 00:38:43」(JST)
[Wiki en表示]
Chlortetracycline
|
| Clinical data |
| AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Routes of
administration |
By mouth, IV, topical |
| ATC code |
- A01AB21 (WHO) D06AA02 (WHO) J01AA03 (WHO) S01AA02 (WHO) QG51AA08 (WHO) QJ51AA03 (WHO)
|
| Pharmacokinetic data |
| Bioavailability |
30% |
| Protein binding |
50 to 55% |
| Metabolism |
Hepatic (75%) |
| Biological half-life |
5.6 to 9 hours |
| Excretion |
Renal and biliary |
| Identifiers |
IUPAC name
- (4S,4aS,5aS,6S,12aR)-7-Chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide[1]
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| CAS Number |
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| PubChem CID |
|
| ChemSpider |
|
| UNII |
|
| KEGG |
|
| ChEMBL |
|
| E number |
E702 (antibiotics) |
| ECHA InfoCard |
100.000.310 |
| Chemical and physical data |
| Formula |
C22H23ClN2O8 |
| Molar mass |
478.882 g/mol[2] |
| 3D model (JSmol) |
|
| Melting point |
168 to 169 °C (334 to 336 °F) |
SMILES
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CN(C)[C@@H]2C(\O)=C(\C(N)=O)C(=O)[C@@]3(O)C(/O)=C4/C(=O)c1c(O)ccc(Cl)c1[C@@](C)(O)[C@H]4C[C@@H]23
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InChI
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InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1 Y
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Key:CYDMQBQPVICBEU-XRNKAMNCSA-N Y
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| NY (what is this?) (verify) |
Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 by Benjamin Minge Duggar working at Lederle Laboratories under the supervision of Yellapragada Subbarow. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.[3] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.[2]
In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.[4]
Chlortetracycline may increase the anticoagulant activities of acenocoumarol. The risk or severity of adverse effects can be increased when chlortetracycline is combined with acitretin, adapalene, or alitretinoin. Aluminum phosphate and aluminum hydroxide can cause decreases in the absorption of chlortetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy. The therapeutic efficacy of mecillinam (amdinocillin), amoxicillin, and ampicillin can be decreased when used in combination with chlortetracycline. Chlortetracycline may increase the neuromuscular blocking activities of atracurium besilate.[5]
References
- ^ "chlortetracycline | C22H23ClN2O8 - PubChem". Pubchem.ncbi.nlm.nih.gov. Retrieved 2017-03-13.
- ^ a b "chlortetracycline | C22H23ClN2O8 - PubChem". Pubchem.ncbi.nlm.nih.gov. Retrieved 2017-03-13.
- ^ Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
- ^ Merck Veterinary Manual. Merckvetmanual.com. Retrieved 2017-03-13.
- ^ "Chlortetracycline - DrugBank". Drugbank.ca. Retrieved 2017-03-13.
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Stomatological preparations (A01)
|
| Caries prophylaxis |
- Dectaflur
- Olaflur
- Sodium fluoride
- Sodium monofluorophosphate
- Stannous fluoride
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| Infection and antiseptics |
- Amphotericin B
- Benzoxonium chloride
- Chlorhexidine
- Chlortetracycline
- Clotrimazole
- Cetylpyridinium chloride
- Domiphen bromide
- Doxycycline
- Eugenol
- Hexetidine
- Hydrogen peroxide
- Mepartricin
- Metronidazole
- Miconazole
- Minocycline
- Natamycin
- Neomycin
- Oxyquinoline
- Polynoxylin
- Sodium perborate
- Tetracycline
- Tibezonium iodide
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Corticosteroids
(Glucocorticoids) |
- Dexamethasone
- Hydrocortisone
- Triamcinolone
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| Other |
- Amlexanox
- Acetylsalicylic acid
- Becaplermin
- Benzydamine
- Epinephrine/Adrenalone
|
|
Antibiotics and chemotherapeutics for dermatological use (D06)
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| Antibiotics |
| Tetracycline and derivatives |
- Demeclocycline
- Chlortetracycline
- Oxytetracycline
- Tetracycline
|
| Others |
- Amphenicol: Chloramphenicol
- Aminoglycosides: Neomycin
- Gentamicin
- Amikacin
- Streptogramin: Virginiamycin
- other: Fusidic acid
- Bacitracin
- Tyrothricin
- Mupirocin
|
|
| Chemotherapeutics |
| Sulfonamides |
- Silver sulfadiazine
- Sulfathiazole
- Mafenide
- Sulfamethizole
- Sulfanilamide
- Sulfamerazine
|
| Antivirals |
- Aciclovir
- Penciclovir
- Idoxuridine
- Edoxudine
- Imiquimod
- Resiquimod
- Podophyllotoxin
- Docosanol
- Tromantadine
- Inosine
- Lysozyme
- Ibacitabine
- Lysine
|
| Other |
- Ingenol mebutate
- Metronidazole
|
|
|
Antibacterials: protein synthesis inhibitors (J01A, J01B, J01F, J01G, QJ01XQ)
|
| 30S |
Aminoglycosides
(initiation inhibitors) |
| -mycin (Streptomyces) |
- Streptomycin#
- Dihydrostreptomycin
- Neomycin#
- Framycetin
- Paromomycin
- Ribostamycin
- Kanamycin#
- Amikacin#
- Arbekacin
- Bekanamycin
- Dibekacin
- Tobramycin
- Spectinomycin#
- Hygromycin B
- Apramycin
- Puromycin
- Nourseothricin
|
| -micin (Micromonospora) |
- Gentamicin#
- Netilmicin
- Sisomicin
- Plazomicin†
- Isepamicin
|
|
Tetracycline antibiotics
(tRNA binding) |
| Tetracyclines |
- Doxycycline#
- Chlortetracycline
- Clomocycline
- Demeclocycline
- Lymecycline
- Meclocycline
- Metacycline
- Minocycline
- Omadacycline†
- Oxytetracycline
- Penimepicycline
- Rolitetracycline
- Sarecycline†
- Tetracycline
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| Glycylcyclines |
|
| Fluorocyclines |
|
|
|
| 50S |
Oxazolidinone
(initiation inhibitors) |
- Eperezolid
- Linezolid#
- Posizolid
- Radezolid
- Ranbezolid
- Sutezolid
- Tedizolid
|
| Peptidyl transferase |
| Amphenicols |
- Chloramphenicol#
- Azidamfenicol
- Thiamphenicol
- Florfenicol
|
| Pleuromutilins |
- Retapamulin
- Tiamulin
- Valnemulin
|
|
| MLS (transpeptidation/translocation) |
| Macrolides |
- Azithromycin#
- Boromycin
- Clarithromycin#
- Dirithromycin
- Erythromycin#
- Flurithromycin
- Josamycin
- Midecamycin
- Miocamycin
- Oleandomycin
- Rokitamycin
- Roxithromycin
- Spiramycin
- Troleandomycin
- Tylosin
- Ketolides
- Telithromycin
- Cethromycin
- Solithromycin†
|
| Lincosamides |
- Clindamycin#
- Lincomycin
- Pirlimycin
|
| Streptogramins |
- Pristinamycin
- Quinupristin/dalfopristin
- Virginiamycin
|
|
|
| EF-G |
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
UpToDate Contents
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English Journal
- Occurrence, fate and mass loadings of antibiotics in two swine wastewater treatment systems.
- Zhang M1, Liu YS2, Zhao JL3, Liu WR4, He LY5, Zhang JN5, Chen J5, He LK5, Zhang QQ5, Ying GG6.
- The Science of the total environment.Sci Total Environ.2018 Oct 15;639:1421-1431. doi: 10.1016/j.scitotenv.2018.05.230. Epub 2018 May 26.
- PMID 29929305
- l-arginine alters the proteome of frozen-thawed bovine sperm during in vitro capacitation.
- Maciel VL Jr1, Caldas-Bussiere MC2, Silveira V3, Reis RS4, Rios AFL5, Paes de Carvalho CS6.
- Theriogenology.Theriogenology.2018 Oct 1;119:1-9. doi: 10.1016/j.theriogenology.2018.06.018. Epub 2018 Jun 27.
- PMID 29958134
- Factors influencing the removal of antibiotic-resistant bacteria and antibiotic resistance genes by the electrokinetic treatment.
- Li H1, Li B2, Zhang Z3, Tian Y2, Ye J2, Lv X4, Zhu C2.
- Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2018 Sep 30;160:207-215. doi: 10.1016/j.ecoenv.2018.05.028. Epub 2018 May 26.
- PMID 29807293
Japanese Journal
- XeCl excimer laser-induced fluorescence for selective ablation of atheromatous tissue.
- XeCl excimer laser - induced fluorescence for selective ablation of atheromatous tissue.
Related Links
- Buy Chlortetracycline hydrochloride (CAS 64-72-2), a specific and potent calcium ionophore antibiotic , from Santa Cruz. Purity: ≥80%,MW: 515.34 ... 同義語 Aureomycin HCI; Auxeomycin; Isphamycin アプリケーション： A specific ...
- Sigma-Aldrich offers Sigma-C4881, Chlortetracycline hydrochloride for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... Application Chlortetracycline was used in ...
★リンクテーブル★
[★]
- 英
- chlortetracycline、chlortetracycline bisulfate、chlortetracycline hydrochloride
- 関
- 塩酸クロルテトラサイクリン、重硫酸クロルテトラサイクリン
[★]
- 英
- chlortetracycline hydrochloride
- 関
- クロルテトラサイクリン、重硫酸クロルテトラサイクリン
[★]
- 関
- chlortetracycline、chlortetracycline hydrochloride
[★]
塩酸デメチルクロルテトラサイクリン
[★]
塩酸塩、ハイドロクロライド