WordNet
- an immune response (chiefly against viral or fungal invasions or transplanted tissue) that involves T cells
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- secure against; "immune from taxation as long as he resided in Bermuda"; "immune from criminal prosecution"
- a person who is immune to a particular infection
- relating to or conferring immunity (to disease or infection) (同)resistant
- (usually followed by `to'
- relating to the condition of immunity; "the immune system"
- a result; "this situation developed in response to events in Africa"
- a phrase recited or sung by the congregation following a versicle by the priest or minister
- the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
- occupy an intermediate or middle position or form a connecting link or stage between two others; "mediate between the old and the new"
- acting through or dependent on an intervening agency; "the disease spread by mediate as well as direct contact"
- acting or brought about through an intervening agency; "the mediated settlement brought satisfaction to both sides"
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 免疫の / 《補語にのみ用いて》(影響・攻撃・義務・税などを)免れている《+『against』(『from, to』)+『名』》
- 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
- 〈紛争・相違点など〉‘を'調停する,仲裁する / 〈妥協・和解・同意など〉‘を'仲裁して成立させる / (両者の)調停をする《+『between』+『名』》 / 仲介者(媒介物)を通じての,間接の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/10 13:16:19」(JST)
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Cell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of phagocytes, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. Historically, the immune system was separated into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells. CD4 cells or helper T cells provide protection against different pathogens. Cytotoxic T cells cause death by apoptosis without using cytokines, therefore in cell mediated immunity cytokines are not always present.
Cellular immunity protects the body by:
- activating antigen-specific cytotoxic T-lymphocytes that are able to induce apoptosis in body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
- activating macrophages and natural killer cells, enabling them to destroy pathogens; and
- stimulating cells to secrete a variety of cytokines that influence the function of other cells involved in adaptive immune responses and innate immune responses.
Cell-mediated immunity is directed primarily at microbes that survive in phagocytes and microbes that infect non-phagocytic cells. It is most effective in removing virus-infected cells, but also participates in defending against fungi, protozoans, cancers, and intracellular bacteria. It also plays a major role in transplant rejection.
Myeloid lineage - Blood (WBC and RBC)
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Cellular/
HSCs |
Myeloid/
CFU-GEMM
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CFU-GM
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CFU-G:
Granulocytes
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Band cell · Neutrophil
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Macrophages
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Histiocytes · Kupffer cells · Alveolar macrophage · Microglia · Osteoclasts · Epithelioid cells · giant cells (Langhans giant cells, Foreign-body giant cell, Touton giant cells)
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CFU-DL
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Dendritic cells · Langerhans cell
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Common
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Myelomonocyte
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CFU-Baso
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Granulocytes (Basophil)
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CFU-Eos
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Granulocytes (Eosinophil)
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MEP
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CFU-Meg
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Megakaryoblast (* primitive Kacheshmarova's cell) · Megakaryocyte (Kacheshmarova's cell) · Platelets
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CFU-E
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Reticulocyte · Normoblast
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CFU-Mast
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Mast cell precursors
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Noncellular |
Plasma
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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Immunology: Lymphocytic adaptive immune system and complement
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Lymphoid |
Antigens
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- Antigen presentation/Professional APCs: Dendritic cell
- Macrophage
- B cell
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Antibodies
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- Antibody
- Monoclonal antibodies
- Polyclonal antibodies
- Autoantibody
- Microantibody
- Polyclonal B cell response
- Allotype
- Isotype
- Idiotype
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Immunity vs.
tolerance
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- action: Immunity
- Autoimmunity
- Alloimmunity
- Allergy
- Hypersensitivity
- Inflammation
- Cross-reactivity
- inaction: Tolerance
- Central
- Peripheral
- Clonal anergy
- Clonal deletion
- Tolerance in pregnancy
- Immunodeficiency
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Immunogenetics
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- Affinity maturation (Somatic hypermutation
- Clonal selection)
- V(D)J recombination
- Junctional diversity
- Immunoglobulin class switching
- MHC/HLA
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Lymphocytes |
- Cellular (T cell)
- Humoral (B cell)
- NK cell
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Substances |
- Cytokines
- Opsonin
- Cytolysin
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Complement |
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cell/phys/auag/auab/comp, igrc
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Immune disorders: hypersensitivity and autoimmune diseases (279.5–6)
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Type I/allergy/atopy
(IgE) |
Foreign
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Atopic dermatitis · Allergic urticaria · Hay fever · Allergic asthma · Anaphylaxis · Food allergy (Milk, Egg, Peanut, Tree nut, Seafood, Soy, Wheat), Penicillin allergy
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Autoimmune
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none
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Type II/ADCC
(IgM, IgG) |
Foreign
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Pernicious anemia · Hemolytic disease of the newborn
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Autoimmune
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Cytotoxic
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Autoimmune hemolytic anemia · Idiopathic thrombocytopenic purpura · Bullous pemphigoid · Pemphigus vulgaris · Rheumatic fever · Goodpasture's syndrome
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"Type 5"/receptor
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Graves' disease · Myasthenia gravis
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Type III
(Immune complex) |
Foreign
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Henoch–Schönlein purpura · Hypersensitivity vasculitis · Reactive arthritis · Farmer's lung · Post-streptococcal glomerulonephritis · Serum sickness · Arthus reaction
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Autoimmune
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Systemic lupus erythematosus · Subacute bacterial endocarditis · Rheumatoid arthritis
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Type IV/cell-mediated
(T-cells) |
Foreign
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Allergic contact dermatitis · Mantoux test
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Autoimmune
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Diabetes mellitus type 1 · Hashimoto's thyroiditis · Guillain–Barré syndrome · Multiple sclerosis · Coeliac disease · Giant-cell arteritis
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GVHD
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Transfusion-associated graft versus host disease
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Unknown/
multiple |
Foreign
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Hypersensitivity pneumonitis (Allergic bronchopulmonary aspergillosis) · Transplant rejection · Latex allergy (I+IV)
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Autoimmune
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Sjögren's syndrome · Autoimmune hepatitis · Autoimmune polyendocrine syndrome (APS1, APS2) · Autoimmune adrenalitis · Systemic autoimmune disease
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cell/phys/auag/auab/comp, igrc
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UpToDate Contents
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English Journal
- Murine Model of Chronic Respiratory Inflammation.
- Lugade AA, Bogner PN, Thanavala Y.Source, .
- Advances in experimental medicine and biology.Adv Exp Med Biol.2012;780:125-141.
- The respiratory mucosa is exposed to the external environment each time we breathe and therefore requires a robust and sophisticated immune defense system. As with other mucosal sites, the respiratory mucosal immune system must balance its response to pathogens while also regulating inflammatory imm
- PMID 21842370
- ELISPOT analysis of a new CTL based DNA vaccine for HIV-1 using GM-CSF in DNA prime/peptide boost strategy: GM-CSF induced long-lived memory responses.
- Mahdavi M, Ebtekar M, Khorram Khorshid HR, Azadmanesh K, Hartoonian C, Hassan ZM.SourceDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Department of Virology, Pasteur Institute of Iran, Tehran, Iran.
- Immunology letters.Immunol Lett.2011 Oct 30;140(1-2):14-20. Epub 2011 May 23.
- Genetic adjuvants have potential role in improvement of immune responses against DNA vaccines. GM-CSF as a genetic adjuvant can recruit and augment dendritic cell numbers in the site of immune responses and thereby induce cellular and humoral immune responses. Here we show that co-immunization of a
- PMID 21679728
Japanese Journal
- 古賀 哲也
- 日本医真菌学会雑誌 = Japanese journal of medical mycology 50(3), 151-154, 2009-07-30
- … This superficial site of infection may protect the infecting dermatophytes from direct contact with some of the effector cells of the immune system; …
- NAID 10026093667
- Appraisal of immunomodulatory potential of Spirulina fusiformis : an in vivo and in vitro study
- RASOOL Mahaboobkhan,SABINA Evan Prince
- Journal of natural medicines 63(2), 169-175, 2009-05-20
- NAID 10025826021
Related Links
- Cell-mediated immunity is an immune response that does not involve antibodies but rather involves the activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in ...
★リンクテーブル★
[★]
- 英
- cell-mediated immune response, CMIR
- 関
- 細胞性免疫
[★]
- 関
- immunisation、immunise、immunity、immunization、immunize、immuno、immunologic
[★]
[★]
- 関
- mediation
[★]
細胞