カルボシステイン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/09 12:55:11」(JST)
[Wiki en表示]
Carbocisteine
|
|
Names |
IUPAC name
(R)-2-Amino-3-(carboxymethylsulfanyl)propanoic acid
|
Other names
S-Carboxymethyl-L-cysteine; Mucodyne, Solmux, Rhinathiol, Humex, Lisomucil, Fluditec, Exputex, Mucolit, Reodyn, Carbotoux, Flemex, Carbolin, Muflex
|
Identifiers |
CAS Number
|
638-23-3 (R) Y
2387-59-9 (RS) N |
ChEBI |
CHEBI:16163 Y |
ChEMBL |
ChEMBL396416 Y |
ChemSpider |
168055 Y |
DrugBank |
DB04339 Y |
InChI
-
InChI=1S/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1 Y
Key: GBFLZEXEOZUWRN-VKHMYHEASA-N Y
-
InChI=1/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)
Key: GBFLZEXEOZUWRN-UHFFFAOYAN
-
InChI=1/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
Key: GBFLZEXEOZUWRN-VKHMYHEABX
|
Jmol interactive 3D |
Image
Image |
KEGG |
D06393 Y |
PubChem |
193653 |
|
UNII |
740J2QX53R Y |
Properties |
Chemical formula
|
C5H9NO4S |
Molar mass |
179.19 g·mol−1 |
Appearance |
Colorless solid |
Melting point |
204 to 207 °C (399 to 405 °F; 477 to 480 K) |
Pharmacology |
ATC code |
R05CB03 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
N verify (what is YN ?) |
Infobox references |
|
|
Carbocisteine (INN), also called carbocysteine (USAN), is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Carbocisteine should not be used with antitussives (cough suppressants) or medicines that dry up bronchial secretions.
Carbocisteine is produced by alkylation of cysteine with chloroacetic acid.[1]
Trade names
- Fluifort: Italy
- Carbex: Pakistan
- Exputex: Ireland
- Fluidol, Humotusin: Romania
- Rhinathiol: Bulgaria, Congo, Hong Kong, Hungary, Latvia, Lithuania, Malaysia, Oman, Romania, Singapore, South Korea, Switzerland, Taiwan, Thailand, Tunisia, and Vietnam[2]
- Mucodyne: United Kingdom, India, Ireland, Japan, Netherlands, Serbia.
- Mucoral: Portugal
- Mucosol: Egypt
- Solmux, Loviscol: Philippines
References
- ^ Karlheinz Drauz, Ian Grayson, Axel Kleemann, Hans-Peter Krimmer, Wolfgang Leuchtenberger, Christoph Weckbecker “Amino Acids” in Ullmann's Encyclopedia of Industrial Chemistry, 2007, Wiley-VCH, Weinheim. doi:10.1002/14356007.a02_057.pub2
- ^ "Rhinathiol". Drugs.com.
Cough and cold preparations (R05)
|
|
Expectorants |
- Althea root
- Antimony pentasulfide
- Creosote
- Guaiacolsulfonate
- Guaifenesin
- Ipecacuanha (Syrup of ipecac)
- Levoverbenone
- Potassium iodide
- Senega
- Tyloxapol
- Ammonium Chloride
|
|
Mucolytics |
- Acetylcysteine
- Ambroxol
- Bromhexine
- Carbocisteine
- Domiodol
- Dornase alfa
- Eprazinone
- Erdosteine
- Letosteine
- Mannitol
- Mesna
- Neltenexine
- Sobrerol
- Stepronin
- Tiopronin
|
|
Cough suppressants |
Opium alkaloids,
opioids,
and derivatives |
- Acetyldihydrocodeine
- Benzylmorphine
- Butorphanol
- Codeine
- Dextromethorphan
- Dihydrocodeine
- Dimemorfan
- Droxypropine
- Ethylmorphine
- Heroin
- Hydrocodone
- Hydromorphone
- Isoaminile
- Laudanum
- Levomethadone
- Levopropoxyphene
- Methadone
- Nicocodeine
- Nicodicodeine
- Normethadone
- Noscapine
- Pholcodine
- Thebacon
- Tipepidine
|
|
Other |
- Benzonatate
- Benproperine
- Bibenzonium bromide
- Butamirate
- Clobutinol
- Clofedanol
- Cloperastine
- Diphenhydramine
- Dibunate
- Dimethoxanate
- Dropropizine
- Fedrilate
- Glaucine
- Levodropropizine
- Meprotixol
- Morclofone
- Nepinalone
- Oxolamine
- Oxeladin
- Pentoxyverine
- Pipazetate
- Prenoxdiazine
- Piperidione
- Zipeprol
|
|
|
Index of the respiratory system
|
|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Chest trauma
- Infection
- common cold
- pneumonia
- tuberculosis
- Other
- Symptoms and signs
|
|
Treatment |
- Procedures
- Drugs
- nasal
- throat
- obstructive airway diseases
- cough and cold
- histaminergics
- pulmonary arterial hypertension
- other
- Surgery
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. COPDに気道粘膜作用薬と気道クリアランスが果たす役割role of mucoactive agents and secretion clearance techniques in copd [show details]
…double-blind trial to receive 500 mg carbocysteine (S-carboxymethyl cysteine) or placebo, three times a day for 12 months . Compared to placebo, patients on carbocysteine had a 0.34 mean reduction in exacerbations …
- 2. 難治性慢性閉塞性肺疾患(COPD)のマネージメントmanagement of refractory chronic obstructive pulmonary disease [show details]
…to triple inhaler therapy. Thiol derivatives such as N-acetylcysteine (NAC), erdosteine and carbocysteine, are mucolytic agents designed to sever disulfide bonds of mucoproteins and DNA, possibly leading …
English Journal
- Carbocisteine protects against emphysema induced by cigarette smoke extract in rats.
- Hanaoka M, Droma Y, Chen Y, Agatsuma T, Kitaguchi Y, Voelkel NF, Kubo K.SourceFirst Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. masayuki@shinshu-u.ac.jp.
- Chest.2011 May;139(5):1101-8. Epub 2010 Sep 16.
- PMID 20847042
- Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.
- Li F, Patterson AD, Hofer CC, Krausz KW, Gonzalez FJ, Idle JR.SourceLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, United States. lif3@mail.nih.gov
- Biochemical pharmacology.2010 Oct 1;80(7):1063-74. Epub 2010 Jun 10.
- Ifosfamide (IF) and cyclophosphamide (CP) are common chemotherapeutic agents. Interestingly, while the two drugs are isomers, only IF treatment is known to cause nephrotoxicity and neurotoxicity. Therefore, it was anticipated that a comparison of IF and CP drug metabolites in the mouse would reveal
- PMID 20541539
Japanese Journal
- PEACE研究 (特集 COPD治療の新時代 : 21世紀の「社会的」生活習慣病) -- (知っておくべき日本のCOPD治療のエビデンス)
- カルボシステインを主剤とした薬剤による固定薬疹の1例 (特集 薬疹・薬物障害)
- A Definite Case of L-carbocisteine-induced Pneumonia with CATCH22 Syndrome
- Kudo Kenichiro,Ichihara Eiki,Hisamoto Akiko,Hotta Katsuyuki,Miyahara Nobuaki,Tanimoto Yasushi,Akagi Sadaharu,Kato Katsuya,Tanimoto Mitsune,Kiura Katsuyuki
- Internal Medicine 52(1), 97-100, 2013
- … A 32-year-old male with CATCH22 syndrome presented with a high fever and productive cough after taking drugs for acute bronchitis, including L-carbocisteine. … Under the assumption of drug-induced pneumonia, or bacterial or viral pneumonia, all drugs including L-carbocisteine were discontinued, and antibiotics were started. … A drug-induced lymphocyte stimulation test was positive only for L-carbocisteine. …
- NAID 130003365553
Related Links
- Carbocisteine helps to make it easier to cough up sputum. It works best when it is taken regularly. There are different liquid medicines available for adults and children. Be aware of the new 'double-strength' medicine for children ...
- What is a Patient Information Leaflet and why is it useful? The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is ...
- Carbocisteine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Carbocisteine is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on ...
★リンクテーブル★
[★]
- 英
- carbocysteine、carbocisteine
- 同
- L-カルボシステイン、L-carbocisteine、S-カルボキシメチルシステイン S-carboxymethyl cysteine
- 商
- C-チステン、カージリン、カルブタン、クインスロン、サワテン、シスカルボン、シスダイン、ムコダイン、ムコチオ、ムコトロン、メチスタ、ルボラボン
- 関
- 去たん剤
概念
- 去痰薬;気道粘液溶解
- システインの残基のH-がHOOC-CH2-で置換されたアミノ酸
作用
- 喀痰中のフコムチンを減少させ、シアロムチンを増加させる
- 粘液構成成分の調整作用、喀痰粘度低下作用、喀痰流動性の改善作用、線毛細胞修復作用を有する
参考
- http://en.wikipedia.org/wiki/Carbocisteine