c-fos gene、c-Fos protein

WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
the 6th letter of the Roman alphabet (同)f

PrepTutorEJDIC

carbonの化学記号
case[s]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/15 00:14:20」(JST)

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[Wiki en表示]

In the fields of molecular biology and genetics, c-Fos is a protein encoded by the FOS gene.^[1]^[2]^[3]

Structure and function

c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at the C-terminus. Transcription of c-Fos is upregulated in response to many extracellular signals, e.g., growth factors. In addition, phosphorylation by MAPK, PKA, PKC or cdc2 alters the activity and stability of c-Fos. Members of the Fos family dimerise with C-jun to form the AP-1 transcription factor, which upregulates transcription of a diverse range of genes involved in everything from proliferation and differentiation to defense against invasion and cell damage.

Clinical significance

The AP-1 complex has been implicated in transformation and progression of cancer, and both c-Fos and c-Jun were first discovered in rat fibroblasts. C-Fos was discovered as the transforming gene of the FBJ MSV and jun, first as the Fos-binding protein p39, then subsequently as the oncogene from avian sarcoma virus 17 (junana = 17).

The viral homologue of c-Fos, v-Fos, is found in the retrovirus Finkel–Biskis–Jinkins murine osteogenic sarcoma virus.

Cocaine, methamphetamine,^[4] heroin,^[5] and other psychoactive drugs^[6]^[7] have been shown to increase c-fos production in prefrontal cortex as well as in the mesolimbic reward pathway. As such, the c-Fos promoter finds utilization in drug abuse research in general, as well as with context-induced relapse to drug-seeking and other behavioral changes associated with chronic drug taking.

An increase in c-Fos production in androgen receptor-containing neurons has been observed in rats after mating.

Applications

Expression of c-fos is an indirect marker of neuronal activity because c-fos is often expressed when neurons fire action potentials.^[8]^[9] Upregulation of c-fos mRNA in a neuron indicates recent activity.^[10]

Drug abuse research also finds application of the c-fos promoter. Scientists use this promoter to turn on transgenes in rats that allow them to manipulate specific neuronal ensembles to assess their role in drug-related memories and behavior.^[11] This neuronal control can be replicated with optogenetics or DREADDs.

Interactions

C-Fos has been shown to interact with:

BCL3,^[12]
COBRA1,^[13]
CSNK2A1,^[14]
CSNK2A2,^[14]
DDIT3,^[15]
JUN^[16]^[17]^[18]^[19]^[20]^[21]^[22]
NCOA1;,^[23]^[24]
NCOR2,^[25]
RELA,^[16]
RUNX1,^[26]^[27]
RUNX2,^[26]^[27]
SMAD3,^[28] and
TBP.^[29]

References

^ Monje P, Hernández-Losa J, Lyons RJ, Castellone MD, Gutkind JS (October 2005). "Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1". J. Biol. Chem. 280 (42): 35081–4. doi:10.1074/jbc.C500353200. PMID 16123044.
^ Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel-Encontre I, Piechaczyk M (August 2005). "Down-Regulation of c-Fos/c-Jun AP-1 Dimer Activity by Sumoylation". Mol. Cell. Biol. 25 (16): 6964–79. doi:10.1128/MCB.25.16.6964-6979.2005. PMC 1190241. PMID 16055710. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1190241/.
^ Konsman JP, Blomqvist A (May 2005). "Forebrain patterns of c-Fos and FosB induction during cancer-associated anorexia-cachexia in rat". Eur. J. Neurosci. 21 (10): 2752–66. doi:10.1111/j.1460-9568.2005.04102.x. PMID 15926923.
^ Graybiel AM, Moratalla R, Robertson HA (September 1990). "Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum". Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6912–6. doi:10.1073/pnas.87.17.6912. PMC 54648. PMID 2118661. //www.ncbi.nlm.nih.gov/pmc/articles/PMC54648/.
^ Curran EJ, Akil H, Watson SJ (November 1996). "Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitized animals". Neurochem. Res. 21 (11): 1425–35. doi:10.1007/BF02532384. PMID 8947933.
^ Nichols CD, Sanders-Bush E (May 2002). "A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain". Neuropsychopharmacology 26 (5): 634–42. doi:10.1016/S0893-133X(01)00405-5. PMID 11927188.
^ Singewald N, Salchner P, Sharp T (February 2003). "Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs". Biol. Psychiatry 53 (4): 275–83. doi:10.1016/S0006-3223(02)01574-3. PMID 12586446.
^ VanElzakker M, Fevurly RD, Breindel T, Spencer RL (2008). "Environmental novelty is associated with a selective increase in Fos expression in the output elements of the hippocampal formation and the perirhinal cortex". Learn. Mem. 15 (12): 899–908. doi:10.1101/lm.1196508. PMC 2632843. PMID 19050162. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2632843/.
^ Dragunow M, Faull R (1989). "The use of c-fos as a metabolic marker in neuronal pathway tracing". Journal of Neuroscience Methods 29 (3): 261–265. doi:10.1016/0165-0270(89)90150-7. PMID 2507830.
^ Day HE, Kryskow EM, Nyhuis TJ, Herlihy L, Campeau S (September 2008). "Conditioned Fear Inhibits c-fos mRNA Expression in the Central Extended Amygdala". Brain Res. 1229: 137–46. doi:10.1016/j.brainres.2008.06.085. PMC 2605076. PMID 18634767. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2605076/.
^ Koya E, Golden SA, Harvey BK, Guez-Barber DH, Berkow A, Simmons DE, Bossert JM, Nair SG, Uejima JL, Marin MT, Mitchell TB, Farquhar D, Ghosh SC, Mattson BJ, Hope BT (August 2009). "Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization". Nat. Neurosci. 12 (8): 1069–73. doi:10.1038/nn.2364. PMC 2752202. PMID 19620976. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2752202/.
^ Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". J. Biol. Chem. 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. PMID 10497212.
^ Zhong H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Q (December 2004). "COBRA1 inhibits AP-1 transcriptional activity in transfected cells". Biochem. Biophys. Res. Commun. 325 (2): 568–73. doi:10.1016/j.bbrc.2004.10.079. PMID 15530430.
^ ^a ^b Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (August 1998). "Casein kinase II interacts with the bZIP domains of several transcription factors". Nucleic Acids Res. 26 (16): 3854–61. doi:10.1093/nar/26.16.3854. PMC 147779. PMID 9685505. //www.ncbi.nlm.nih.gov/pmc/articles/PMC147779/.
^ Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. 19 (11): 7589–99. PMC 84780. PMID 10523647. //www.ncbi.nlm.nih.gov/pmc/articles/PMC84780/.
^ ^a ^b Yang X, Chen Y, Gabuzda D (September 1999). "ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB". J. Biol. Chem. 274 (39): 27981–8. doi:10.1074/jbc.274.39.27981. PMID 10488148.
^ Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H (January 2001). "Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers". J. Biol. Chem. 276 (4): 2852–7. doi:10.1074/jbc.M009633200. PMID 11053448.
^ Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.
^ Glover JN, Harrison SC (January 1995). "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA". Nature 373 (6511): 257–61. doi:10.1038/373257a0. PMID 7816143.
^ Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (February 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J. Biol. Chem. 268 (6): 4259–66. PMID 8440710.
^ Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF (January 1993). "Detection and modulation in vivo of helix-loop-helix protein-protein interactions". J. Biol. Chem. 268 (1): 5–8. PMID 8380166.
^ Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.
^ Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (June 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. doi:10.1210/me.14.6.915. PMID 10847592.
^ Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW (July 1998). "Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits". J. Biol. Chem. 273 (27): 16651–4. doi:10.1074/jbc.273.27.16651. PMID 9642216.
^ Lee SK, Kim JH, Lee YC, Cheong J, Lee JW (April 2000). "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor". J. Biol. Chem. 275 (17): 12470–4. doi:10.1074/jbc.275.17.12470. PMID 10777532.
^ ^a ^b Hess J, Porte D, Munz C, Angel P (June 2001). "AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element". J. Biol. Chem. 276 (23): 20029–38. doi:10.1074/jbc.M010601200. PMID 11274169.
^ ^a ^b D'Alonzo RC, Selvamurugan N, Karsenty G, Partridge NC (January 2002). "Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation". J. Biol. Chem. 277 (1): 816–22. doi:10.1074/jbc.M107082200. PMID 11641401.
^ Zhang Y, Feng XH, Derynck R (August 1998). "Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription". Nature 394 (6696): 909–13. doi:10.1038/29814. PMID 9732876.
^ Metz R, Bannister AJ, Sutherland JA, Hagemeier C, O'Rourke EC, Cook A, Bravo R, Kouzarides T (September 1994). "c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein". Mol. Cell. Biol. 14 (9): 6021–9. doi:10.1128/MCB.14.9.6021. PMC 359128. PMID 8065335. //www.ncbi.nlm.nih.gov/pmc/articles/PMC359128/.

External links

c-fos+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
c-fos+Genes at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook C-Fos
Drosophila kayak - The Interactive Fly

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「c-Fos protein」

FBJ murine osteosarcoma viral oncogene homolog
	; PDB rendering based on 1a02.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1A02, 1FOS, 1S9K
Identifiers
Symbols	FOS; AP-1; C-FOS; p55
External IDs	OMIM: 164810 MGI: 95574 HomoloGene: 3844 ChEMBL: 5029 GeneCards: FOS Gene
Gene Ontology
Molecular function	• double-stranded DNA binding; • sequence-specific DNA binding transcription factor activity; • protein binding; • sequence-specific DNA binding; • transcription regulatory region DNA binding; • R-SMAD binding;
Cellular component	• nucleus; • nucleoplasm; • transcription factor complex; • nucleolus;
Biological process	• conditioned taste aversion; • toll-like receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • DNA methylation; • regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • inflammatory response; • transforming growth factor beta receptor signaling pathway; • nervous system development; • female pregnancy; • aging; • Toll signaling pathway; • response to cold; • response to light stimulus; • response to mechanical stimulus; • response to gravity; • response to toxin; • sleep; • cellular response to extracellular stimulus; • response to lipopolysaccharide; • response to progesterone stimulus; • cellular response to hormone stimulus; • response to cytokine stimulus; • toll-like receptor 1 signaling pathway; • toll-like receptor 2 signaling pathway; • toll-like receptor 3 signaling pathway; • toll-like receptor 4 signaling pathway; • cellular response to reactive oxygen species; • TRIF-dependent toll-like receptor signaling pathway; • response to drug; • innate immune response; • positive regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter; • regulation of sequence-specific DNA binding transcription factor activity; • stress-activated MAPK cascade; • response to corticosterone stimulus; • response to cAMP; • SMAD protein signal transduction; • cellular response to calcium ion;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

c-Fosタンパク質

関: Fos-related antigen、FRA、proto-oncogene protein c-Fos

「proto-oncogene protein c-Fos」

　　[★]

癌原遺伝子産物c-Fos

関: c-Fos protein、Fos-related antigen、FRA

「癌原遺伝子産物c-Fos」

　　[★]

英: proto-oncogene protein c-Fos
関: c-Fosタンパク質、Fos関連抗原

「c-Fosタンパク質」

　　[★]

英: c-Fos protein
関: 癌原遺伝子産物c-Fos、Fos関連抗原

「C」

　　[★]

炭素 carbon
シトシン cytosine
システイン cysteine
シチジン
セルシウス度摂氏 degrees Celsius degree C
産婦人科領域で「子宮外頚子宮外頚部 exocervix」を表現するための略語

「F」

　　[★] フェニルアラニン phenylalanine 　

「c」

　　[★]

光速, speed of light

[pmid16123044-1] Monje P, Hernández-Losa J, Lyons RJ, Castellone MD, Gutkind JS (October 2005). "Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1". J. Biol. Chem. 280 (42): 35081–4. doi:10.1074/jbc.C500353200. PMID 16123044.

[pmid16055710-2] Bossis G, Malnou CE, Farras R, Andermarcher E, Hipskind R, Rodriguez M, Schmidt D, Muller S, Jariel-Encontre I, Piechaczyk M (August 2005). "Down-Regulation of c-Fos/c-Jun AP-1 Dimer Activity by Sumoylation". Mol. Cell. Biol. 25 (16): 6964–79. doi:10.1128/MCB.25.16.6964-6979.2005. PMC 1190241. PMID 16055710. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1190241/.

[pmid15926923-3] Konsman JP, Blomqvist A (May 2005). "Forebrain patterns of c-Fos and FosB induction during cancer-associated anorexia-cachexia in rat". Eur. J. Neurosci. 21 (10): 2752–66. doi:10.1111/j.1460-9568.2005.04102.x. PMID 15926923.

[pmid2118661-4] Graybiel AM, Moratalla R, Robertson HA (September 1990). "Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum". Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6912–6. doi:10.1073/pnas.87.17.6912. PMC 54648. PMID 2118661. //www.ncbi.nlm.nih.gov/pmc/articles/PMC54648/.

[pmid8947933-5] Curran EJ, Akil H, Watson SJ (November 1996). "Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitized animals". Neurochem. Res. 21 (11): 1425–35. doi:10.1007/BF02532384. PMID 8947933.

[pmid11927188-6] Nichols CD, Sanders-Bush E (May 2002). "A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain". Neuropsychopharmacology 26 (5): 634–42. doi:10.1016/S0893-133X(01)00405-5. PMID 11927188.

[pmid12586446-7] Singewald N, Salchner P, Sharp T (February 2003). "Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs". Biol. Psychiatry 53 (4): 275–83. doi:10.1016/S0006-3223(02)01574-3. PMID 12586446.

[pmid19050162-8] VanElzakker M, Fevurly RD, Breindel T, Spencer RL (2008). "Environmental novelty is associated with a selective increase in Fos expression in the output elements of the hippocampal formation and the perirhinal cortex". Learn. Mem. 15 (12): 899–908. doi:10.1101/lm.1196508. PMC 2632843. PMID 19050162. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2632843/.

[pmid2507830-9] Dragunow M, Faull R (1989). "The use of c-fos as a metabolic marker in neuronal pathway tracing". Journal of Neuroscience Methods 29 (3): 261–265. doi:10.1016/0165-0270(89)90150-7. PMID 2507830.

[pmid18634767-10] Day HE, Kryskow EM, Nyhuis TJ, Herlihy L, Campeau S (September 2008). "Conditioned Fear Inhibits c-fos mRNA Expression in the Central Extended Amygdala". Brain Res. 1229: 137–46. doi:10.1016/j.brainres.2008.06.085. PMC 2605076. PMID 18634767. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2605076/.

[pmid19620976-11] Koya E, Golden SA, Harvey BK, Guez-Barber DH, Berkow A, Simmons DE, Bossert JM, Nair SG, Uejima JL, Marin MT, Mitchell TB, Farquhar D, Ghosh SC, Mattson BJ, Hope BT (August 2009). "Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization". Nat. Neurosci. 12 (8): 1069–73. doi:10.1038/nn.2364. PMC 2752202. PMID 19620976. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2752202/.

[pmid10497212-12] Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". J. Biol. Chem. 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. PMID 10497212.

[pmid15530430-13] Zhong H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Q (December 2004). "COBRA1 inhibits AP-1 transcriptional activity in transfected cells". Biochem. Biophys. Res. Commun. 325 (2): 568–73. doi:10.1016/j.bbrc.2004.10.079. PMID 15530430.

[pmid9685505-14] Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (August 1998). "Casein kinase II interacts with the bZIP domains of several transcription factors". Nucleic Acids Res. 26 (16): 3854–61. doi:10.1093/nar/26.16.3854. PMC 147779. PMID 9685505. //www.ncbi.nlm.nih.gov/pmc/articles/PMC147779/.

[pmid10523647-15] Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. 19 (11): 7589–99. PMC 84780. PMID 10523647. //www.ncbi.nlm.nih.gov/pmc/articles/PMC84780/.

[pmid10488148-16] Yang X, Chen Y, Gabuzda D (September 1999). "ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB". J. Biol. Chem. 274 (39): 27981–8. doi:10.1074/jbc.274.39.27981. PMID 10488148.

[pmid11053448-17] Ito T, Yamauchi M, Nishina M, Yamamichi N, Mizutani T, Ui M, Murakami M, Iba H (January 2001). "Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers". J. Biol. Chem. 276 (4): 2852–7. doi:10.1074/jbc.M009633200. PMID 11053448.

[pmid9160889-18] Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.

[pmid7816143-19] Glover JN, Harrison SC (January 1995). "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA". Nature 373 (6511): 257–61. doi:10.1038/373257a0. PMID 7816143.

[pmid8440710-20] Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (February 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J. Biol. Chem. 268 (6): 4259–66. PMID 8440710.

[pmid8380166-21] Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF (January 1993). "Detection and modulation in vivo of helix-loop-helix protein-protein interactions". J. Biol. Chem. 268 (1): 5–8. PMID 8380166.

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拡張検索	「c-Fos protein」「proto-oncogene protein c-Fos」「癌原遺伝子産物c-Fos」「c-Fosタンパク質」
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c-Fos