binding domain

• 結合領域、結合ドメイン

WordNet

1. executed with proper legal authority; "a binding contract"
2. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
3. strip sewn over or along an edge for reinforcement or decoration
4. the capacity to attract and hold something
5. territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land" (同)demesne, land
6. (mathematics) the set of values of the independent variable for which a function is defined (同)domain of a function

PrepTutorEJDIC

1. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
2. (国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/11 02:32:29」(JST)

wiki en

[Wiki en表示]

A binding domain is a protein domain which binds to a specific atom or molecule, such as calcium or DNA. Protein Domain is a part of a protein sequence and a tertiary structure that can change, function, and live by itself for the rest of the protein chain. (Phillips 1). Upon binding, proteins may undergo a conformational change. Binding domains are essential for the function of many proteins. They are essential because they help splice, assemble, and translate proteins. (Yong 1).

Examples of binding domains include Zinc finger, which binds to DNA, and EF hand, which binds to calcium.    

See also

• DNA-binding domain

References

1.     Phillips DC. (1966). "The three-dimensional structure of an enzyme molecule". Scientific

American. 215 (5): 78–90. doi:10.1038/scientificamerican1166-78.  

PMID 5978599.

2.     Yong, J., T. J. Golembe, D. J. Battle, L. Pellizzoni, and G. Dreyfuss. "SnRNAs Contain

Specific SMN-binding Domains That Are Essential for SnRNP Assembly."

Molecular and Cellular Biology. U.S. National Library of Medicine, Apr. 2004.

Web. 06 Apr. 2017.

UpToDate Contents

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English Journal

• Effect of thermal denaturation, inhibition, and cleavage of disulfide bonds on the low-frequency Raman and FTIR spectra of chymotrypsin and albumin.

• Brandt NN1, Chikishev AY2, Mankova AA1, Sakodynskaya IK3.
• Journal of biomedical optics.J Biomed Opt.2015 May;20(5):051015. doi: 10.1117/1.JBO.20.5.051015.
• The analysis of the structure-function relationship is extremely important in the study of proteins. The importance of function-related motions of large parts or subglobules of protein molecules stimulates the spectroscopic study in the low-frequency (terahertz) domain. However, only tentative assig
• PMID 25478913

• Gold nanostar based biosensor detects epigenetic alterations on promoter of real cells.

• Nguyen AH1, Ma X1, Sim SJ2.
• Biosensors & bioelectronics.Biosens Bioelectron.2015 Apr 15;66:497-503. doi: 10.1016/j.bios.2014.12.015. Epub 2014 Dec 5.
• Epigenetic changes, particularly in cancer suppressor genes, are novel biomarkers for cancer diagnostics and therapeutics. However, epigenetic studies should not only provide an estimation of the amount of 5-methylcytosine, but also examine the presence of epigenetic proteins to reveal the complete
• PMID 25500525

• Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3-FOXO1 pathway.

• Miao H1, Ou J1, Zhang X1, Chen Y1, Xue B2, Shi H2, Gan L3, Yu L4, Liang H1.
• Clinical science (London, England : 1979).Clin Sci (Lond).2015 Apr 1;128(8):493-506. doi: 10.1042/CS20140414.
• Over-nutrition induces low-grade inflammation that dampens insulin sensitivity, but the underlying molecular mediators are not fully understood. Comparative gene identification-58 (CGI-58) is an intracellular lipolytic activator. In the present study, we show that in mouse visceral fat-derived macro
• PMID 25431838

Japanese Journal

• Mannose-recognition mutant of the galactose/N-acetylgalactosamine-specific C-type lectin CEL-I engineered by site-directed mutagenesis

• Moriuchi Hiromi,Unno Hideaki,Goda Shuichiro,Tateno Hiroaki,Hirabayashi Jun,Hatakeyama Tomomitsu
• Biochimica et Biophysica Acta (BBA) - General Subjects 1850(7), 1457-1465, 2015-07
• … Its carbohydrate-binding site contains a QPD (Gln-Pro-Asp) motif, which is generally recognized as the galactose specificity-determining motif in the C-type lectins. … In our previous study, replacement of the QPD motif by an EPN (Glu-Pro-Asn) motif led to a weak binding affinity for mannose. … Therefore, we examined the effects of an additional mutation in the carbohydrate-binding site on the specificity of the lectin. …
• NAID 120005611344

• NLRP3 Mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation

• Kinoshita Takeshi,Imamura Ryu,Kushiyama Hiroko,Suda Takashi
• PLoS ONE 10(3), e0119179, 2015-03-15
• … Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain containing 3 (NLRP3) has recently emerged as a central regulator of innate immunity and inflammation in response to both sterile inflammatory and microbial invasion signals. …
• NAID 120005611526

• <i>In silico</i> spleen tyrosine kinase inhibitor screening by chooseLD

• Hideaki Umeyama,Mitsuo Iwadate,Y-H. Taguchi
• 研究報告バイオ情報学（BIO） 2015-BIO-41(9), 1-6, 2015-03-13
• … Furthermore, many compounds in the DrugBank database were newly identified as having high affinity to ATP binding sites in the kinase domain with a similar affinity to previously reported inhibitors. … Furthermore, many compounds in the DrugBank database were newly identified as having high affinity to ATP binding sites in the kinase domain with a similar affinity to previously reported inhibitors. …
• NAID 170000121229

Related Links

• Binding domain | definition of binding domain by Medical ...

binding domain Any structural motif present on a DNA-binding regulatory protein which controls gene expression, either enhancing or repressing mRNA synthesis. Binding proteins recognise sequence-specific binding domains on ...

• Ligand Binding Domain - Theoretical and Computational ...

The domain responsible for hormone binding is the ligand binding domain (LBD). This domain participates in several activities including hormone binding, homo- and/or heterodimerization, formation of the heat-shock ...

• NAD(P)-binding domain (IPR016040) < InterPro < EMBL-EBI

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource ...

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★リンクテーブル★

リンク元	「結合領域」「結合ドメイン」
拡張検索	「DNA-binding domain」「calmodulin binding domain」
関連記事	「binding」「domain」「domains」

「結合領域」

　　[★]

英

binding domain

関

結合ドメイン

「結合ドメイン」

　　[★]

英

binding domain

関

結合領域

「DNA-binding domain」

　　[★]

• DNA結合ドメイン、DNA結合領域

「calmodulin binding domain」

　　[★] カルモジュリン結合ドメイン

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「domain」

　　[★]

• n.

• ドメイン、(分子内の)領域、分域

関

area、realm、region、regional、segregation、territory、universe

　 　 　

「domains」

　　[★]

関

See also specific type