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formed like a bacillus (同)bacillary, bacilliform, baculiform, rod-shaped
relating to or produced by or containing bacilli (同)bacillary

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/08 06:27:17」(JST)

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Bacillary angiomatosis (BA) is a form of angiomatosis associated with bacteria of the Bartonella genus.

§Causes

It is caused by either Bartonella henselae or Bartonella quintana.^[1]

Bartonella henselae is most often transmitted through a cat scratch or bite,^[2] though ticks and fleas may also act as a vector.
Bartonella quintana is usually transmitted by lice.

It can manifest in people with AIDS^[3] and rarely appears in those who are immunocompetent.^{[citation needed]}

§Presentation

BA is characterised by the proliferation of blood vessels, resulting in them forming tumour-like masses in the skin and other organs.

§Symptoms

Cutaneous BA is characterised by the presence of lesions on or under the skin. Appearing in numbers from one to hundreds, these lesions may take several forms:

papules or nodules which are red, globular and non-blanching, with a vascular appearance
purplish nodules sufficiently similar to Kaposi's sarcoma that a biopsy may be required to verify which of the two it is
a purplish lichenoid plaque
a subcutaneous nodule which may have ulceration, similar to a bacterial abscess

While cutaneous BA is the most common form of BA, BA can also affect several other parts of the body, such as the brain, bone, bone marrow, lymph nodes, gastrointestinal tract, respiratory tract, spleen and liver. Symptoms vary depending on which parts of the body are affected; for example, those whose livers are affected may have an enlarged liver and fever, while those with osseous BA will experience intense pain in the affected area.

§Treatment and prevention

While curable, it is potentially fatal if not treated.

BA responds dramatically to several antibiotics. Usually, erythromycin will cause the skin lesions to gradually fade away in the next four weeks, resulting in complete recovery. Doxycycline may also be used. However, if the infection does not respond to either of these, the medication is usually changed to tetracycline. If the infection is serious, then a bactericidal medication may be coupled with the antibiotics.

If a cat is carrying Bartonella henselae, then it may not exhibit any symptoms. Cats may be bacteremic for weeks to years, but infection is more common in young cats. Transmission to humans is thought to occur via flea feces inoculated into a cat scratch or bite, and transmission between cats occurs only in the presence of fleas. Therefore, elimination and control of fleas in the cat's environment are key to prevention of infection in both cats and humans.

§History

The condition that later became known as bacillary angiomatosis was first described by Stoler and associates in 1983.^[4] Being unaware of its infectious origin, it was originally called epithelioid angiomatosis.^[5] Following documentation of bacilli in Warthin-Starry stains and by electron microscopy in a series of cases by LeBoit and colleagues, the term bacillary angiomatosis was widely adopted.^[6]

§See also

Cat scratch fever
Trench fever
Angiomatosis

§References

^ Koehler JE, Sanchez MA, Garrido CS, et al. (December 1997). "Molecular epidemiology of bartonella infections in patients with bacillary angiomatosis-peliosis". N. Engl. J. Med. 337 (26): 1876–83. doi:10.1056/NEJM199712253372603. PMID 9407154.
^ Mateen FJ, Newstead JC, McClean KL (July 2005). "Bacillary angiomatosis in an HIV-positive man with multiple risk factors: A clinical and epidemiological puzzle". Can J Infect Dis Med Microbiol 16 (4): 249–52. PMC 2095030. PMID 18159553.
^ Gasquet S, Maurin M, Brouqui P, Lepidi H, Raoult D (1998). "Bacillary angiomatosis in immunocompromised patients.". AIDS 12 (14): 1793–803. doi:10.1097/00002030-199814000-00011. PMID 9792380.
^ Stoler MH, Bonfiglio TA, Steigbigel RT, Pereira M. An atypical subcutaneous infection associated with acquired immune deficiency syndrome. Am J Clin Pathol. 1983 Nov;80(5):714-8
^ Cockerell CJ, Whitlow MA, Webster GF, Friedman-Kien AE. Epithelioid angiomatosis: a distinct vascular disorder in patients with the acquired immunodeficiency syndrome or AIDS-related complex. Lancet. 1987 Sep 19;2(8560):654-6
^ LeBoit PE, Berger TG, Egbert BM, Beckstead JH, Yen TS, Stoler MH. Bacillary angiomatosis. The histopathology and differential diagnosis of a pseudoneoplastic infection in patients with human immunodeficiency virus disease. Am J Surg Pathol. 1989 Nov;13(11):909-20.

UpToDate Contents

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1. HIV感染患者におけるバルトネラ感染症の疫学および臨床症状 epidemiology and clinical manifestations of bartonella infections in hiv infected patients
2. バルトネラ・クインターナ感染の臨床的特徴、診断、および治療 clinical features diagnosis and treatment of bartonella quintana infections
3. 化膿性肉芽腫（小葉状毛細血管腫） pyogenic granuloma lobular capillary hemangioma
4. 肝紫斑病 peliosis hepatis
5. HIV感染患者における発熱および発疹 fever and rash in hiv infected patients

English Journal

Multiplexed colorimetric detection of Kaposi's sarcoma associated herpesvirus and Bartonella DNA using gold and silver nanoparticles.

Mancuso M, Jiang L, Cesarman E, Erickson D.SourceDepartment of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Nanoscale.Nanoscale.2013 Jan 31;5(4):1678-86. doi: 10.1039/c3nr33492a.
Kaposi's sarcoma (KS) is an infectious cancer occurring most commonly in human immunodeficiency virus (HIV) positive patients and in endemic regions, such as Sub-Saharan Africa, where KS is among the top four most prevalent cancers. The cause of KS is the Kaposi's sarcoma-associated herpesvirus (KSH
PMID 23340972

Infection of human brain vascular pericytes (HBVPs) by Bartonella henselae.

Varanat M, Maggi RG, Linder KE, Breitschwerdt EB.SourceIntracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
Medical microbiology and immunology.Med Microbiol Immunol.2012 Nov 25. [Epub ahead of print]
Angiogenesis is an important physiological and pathological process. Bartonella is the only genus of bacteria known to induce pathological angiogenesis in the mammalian host. Bartonella-induced angiogenesis leads to the formation of vascular tumors including verruga peruana and bacillary angiomatosi
PMID 23184416

Bartonella henselae trimeric autotransporter adhesin BadA expression interferes with effector translocation by the VirB/D4 type IV secretion system.

Lu YY, Franz B, Truttmann MC, Riess T, Gay-Fraret J, Faustmann M, Kempf VA, Dehio C.SourceFocal Area Infection Biology, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland.
Cellular microbiology.Cell Microbiol.2012 Nov 16. doi: 10.1111/cmi.12070. [Epub ahead of print]
The Gram-negative, zoonotic pathogen Bartonella henselae is the aetiological agent of cat scratch disease, bacillary angiomatosis and peliosis hepatis in humans. Two pathogenicity factors of B. henselae - each displaying multiple functions in host cell interaction - have been characterized in grea
PMID 23163798

Japanese Journal

HIV-negative case of bacillary angiomatosis with chronic hepatitis B

KACAR Nida,TASLI Levent,DEMIRKAN Nese,ERGIN Cagri,ERGIN Seniz
Journal of dermatology 37(8), 722-725, 2010-08-01
NAID 10027066970

猫ひっかき病 (特集子どもと動物--上手にふれあうためには) -- (動物由来感染症各論)

丸山総一
小児科臨床 62(4), 703-708, 2009-04
NAID 40016485447

Abdominal inflammatory masses mimicking neoplasia in children : experience of two centers

CZAUDERNA Piotr,SCHAARSCHMIDT Klaus,KOMASARA Leszek,HARMS Dieter,LEMPE Michael,VORPAHL Klaus,SZUMERA Malgorzata,BALANDA Alicja
Pediatric surgery international 21(5), 346-350, 2005-05-01
NAID 10019040091

Related Pictures

★リンクテーブル★

リンク元	「Bartonella quintana」「BA」「細菌性血管腫症」「細菌性血管腫」
関連記事	「bacillary」「bacillar」「angiomatosis」

「Bartonella quintana」

Bacillary angiomatosis
Classification and external resources
ICD-10	A44.8 (ILDS A44.85), B20.1 (ILDS B20.11)
ICD-9	088.0
DiseasesDB	2173
eMedicine	derm/44
Patient UK	Bacillary angiomatosis
MeSH	D016917