asparagine-tRNA ligase

アスパラギンtRNAリガーゼ

関

asparaginyl-tRNA synthetase

WordNet

1. a crystalline amino acid found in proteins and in many plants (e.g., asparagus)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/21 23:56:15」(JST)

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asparagine-tRNA ligase
Identifiers
EC number	6.1.1.22
CAS number	37211-76-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an asparagine-tRNA ligase (EC 6.1.1.22) is an enzyme that catalyzes the chemical reaction

ATP + L-asparagine + tRNAAsn AMP + diphosphate + L-asparaginyl-tRNAAsn

The 3 substrates of this enzyme are ATP, L-asparagine, and tRNA(Asn), whereas its 3 products are AMP, diphosphate, and L-asparaginyl-tRNA(Asn).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-asparagine:tRNAAsn ligase (AMP-forming). Other names in common use include asparaginyl-tRNA synthetase, asparaginyl-transfer ribonucleate synthetase, asparaginyl transfer RNA synthetase, asparaginyl transfer ribonucleic acid synthetase, asparagyl-transfer RNA synthetase, and asparagine translase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1X54, 1X55, and 1X56.

References

• Davies MR, Marshall RD (1972). "Partial purification of L-asparaginyl-tRNA synthetase from rabbit liver". Biochem. Biophys. Res. Commun. 47 (6): 1386–95. doi:10.1016/0006-291X(72)90226-4. PMID 5040239. 

UpToDate Contents

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English Journal

• Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites.

• Rateb ME1, Yang D1, Vodanovic-Jankovic S2, Yu Z1, Kron MA2, Shen B3.
• The Journal of antibiotics.J Antibiot (Tokyo).2015 Mar 4. doi: 10.1038/ja.2015.22. [Epub ahead of print]
• PMID 25735843

• Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome.

• Simon M1, Richard EM2, Wang X3, Shahzad M2, Huang VH3, Qaiser TA4, Potluri P5, Mahl SE6, Davila A7, Nazli S4, Hancock S8, Yu M9, Gargus J10, Chang R11, Al-Sheqaih N12, Newman WG12, Abdenur J11, Starr A13, Hegde R14, Dorn T15, Busch A16, Park E17, Wu J18, Schwenzer H19, Flierl A20, Florentz C19, Sissler M19, Khan SN4, Li R3, Guan MX3, Friedman TB21, Wu DK22, Procaccio V23, Riazuddin S24, Wallace DC5, Ahmed ZM2, Huang T3, Riazuddin S2.
• PLoS genetics.PLoS Genet.2015 Mar 25;11(3):e1005097. doi: 10.1371/journal.pgen.1005097. eCollection 2015.
• Here we demonstrate association of variants in the mitochondrial asparaginyl-tRNA synthetase NARS2 with human hearing loss and Leigh syndrome. A homozygous missense mutation ([c.637G>T; p.Val213Phe]) is the underlying cause of nonsyndromic hearing loss (DFNB94) and compound heterozygous mutations
• PMID 25807530

• Two siblings with homozygous pathogenic splice-site variant in mitochondrial asparaginyl-tRNA synthetase (NARS2).

• Vanlander AV1, Menten B, Smet J, De Meirleir L, Sante T, De Paepe B, Seneca S, Pearce SF, Powell CA, Vergult S, Michotte A, De Latter E, Vantomme L, Minczuk M, Van Coster R.
• Human mutation.Hum Mutat.2015 Feb;36(2):222-31. doi: 10.1002/humu.22728.
• A homozygous missense mutation (c.822G>C) was found in the gene encoding the mitochondrial asparaginyl-tRNA synthetase (NARS2) in two siblings born to consanguineous parents. These siblings presented with different phenotypes: one had mild intellectual disability and epilepsy in childhood, wherea
• PMID 25385316

Related Links

• GO:0004816 asparagine-tRNA ligase activity

The European Bioinformatics Institute ... Database Code Database Name UniProtKB Universal Protein Knowledgebase UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot UniProtKB/TrEMBL UniProtKB-TrEMBL protein sequence database

• Asparagine-tRNA Ligase (Cytokines & Cells Encyclopedia ...

COPE Homepage Bottom of page Previous entry: ASP Next entry: Asparaginyl-tRNA synthetase Random entry: Angiogenin-4 Search COPE: COPEing Friends for COPE Fund Asparagine-tRNA Ligase approved gene symbol: NARS. abbr. ...

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★リンクテーブル★

リンク元	「asparaginyl-tRNA synthetase」「アスパラギンtRNAリガーゼ」
関連記事	「asparagine」「tRNA」「ligase」「tRNAs」「tRNA ligase」

「asparaginyl-tRNA synthetase」

　　[★]

アスパラギニルtRNA合成酵素、アスパラギニルtRNAシンテターゼ

関

asparagine-tRNA ligase

「アスパラギンtRNAリガーゼ」

　　[★]

英

asparagine-tRNA ligase

関

アスパラギニルtRNA合成酵素

「asparagine」

　　[★]

アスパラギン

関

Asn、L-asparagine、N

　

「tRNA」

　　[★] トランスファーRNA, transfer RNA, 転位RNA

「ligase」

　　[★]

リガーゼ、連結酵素

関

synthetase

「tRNAs」

　　[★] トランスファーRNA transfer RNAs

「tRNA ligase」

　　[★]

tRNAリガーゼ

関

RNA ligase