WordNet

do over; "They would like to take it over again" (同)take_over
an event that repeats; "the events today were a repeat of yesterdays" (同)repetition
to say again or imitate; "followers echoing the cries of their leaders" (同)echo
to say, state, or perform again; "She kept reiterating her request" (同)reiterate, ingeminate, iterate, restate, retell
burrowing chiefly nocturnal mammal with body covered with strong horny plates

PrepTutorEJDIC

〈自分がすでに一度言ったこと)‘を'『繰り返して言う』 / 〈他人の言ったこと〉‘を'おうむ返しに言う;…‘を'他の人に繰り返して言う / …‘を'『暗記して言う』,暗唱する / …‘を'繰り返して行う(do again) / (食べたあとで)〈食物の〉味が残る / 〈小数が〉循環する / 繰り返すこと,反復すること / 繰り返されるもの,(公演の)再演;(番組の)再放送 / 反復楽節;反復記号(∥: :∥)
アルマジロ(中南米産の小動物)
繰り返して言われる(行われる)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/01 08:59:02」(JST)

wiki en

An armadillo repeat is the name of a characteristic, repetitive amino acid sequence of about 40 residues in length that is found in many proteins. Proteins that contain armadillo repeats typically contain several tandemly repeated copies.^[2]^[3] Each Armadillo repeat is composed of a pair of alpha helices that form a hairpin structure. Multiple copies of the repeat form what is known as an alpha solenoid structure.

Examples of proteins that contain armadillo repeats include β-catenin, α-importin,^[4] plakoglobin,^[5] adenomatous polyposis coli (APC),^[6] and many others.

The term armadillo derives from the historical name of the β-catenin gene in the fruitfly Drosophila where the armadillo repeat was first discovered. β-catenin is a protein involved in linking cadherin cell adhesion proteins to the cytoskeleton,^[1] but the armadillo repeat is found in a wide range of proteins with other functions. This type of protein domain is important in transducing WNT signals during embryonic development.

Structure

The 3-dimensional fold of an armadillo repeat was first observed in the crystal structure of beta-catenin, where the 12 repeats form a superhelix of alpha helices with three helices per unit.^[1] The cylindrical structure features a positively charged groove, which presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin.^[7]

References

^ ^a ^b ^c Huber AH, Nelson WJ, Weis WI (September 1997). "Three-dimensional structure of the armadillo repeat region of beta-catenin". Cell 90 (5): 871–82. doi:10.1016/S0092-8674(00)80352-9. PMID 9298899.
^ Peifer M, Berg S, Reynolds AB (1994). "A repeating amino acid motif shared by proteins with diverse cellular roles". Cell 76 (5): 789–91. doi:10.1016/0092-8674(94)90353-0. PMID 7907279.
^ Groves MR, Barford D (1999). "Topological characteristics of helical repeat proteins". Current Opinion in Structural Biology 9 (3): 383–9. doi:10.1016/S0959-440X(99)80052-9. PMID 10361086.
^ Herold A, Truant R, Wiegand H, Cullen BR (October 1998). "Determination of the functional domain organization of the importin alpha nuclear import factor". J. Cell Biol. 143 (2): 309–18. doi:10.1083/jcb.143.2.309. PMC 2132842. PMID 9786944.
^ McCrea PD, Turck CW, Gumbiner B (November 1991). "A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin". Science 254 (5036): 1359–61. doi:10.1126/science.1962194. PMID 1962194.
^ Hirschl D, Bayer P, Müller O (March 1996). "Secondary structure of an armadillo single repeat from the APC protein". FEBS Lett. 383 (1-2): 31–6. doi:10.1016/0014-5793(96)00215-3. PMID 8612785.
^ "Armadillo (IPR000225)". InterPro. EMBL-EBI.

External links

Eukaryotic Linear Motif resource motif class TRG_NLS_Bipartite_1
Eukaryotic Linear Motif resource motif class TRG_NLS_MonoCore_2
Eukaryotic Linear Motif resource motif class TRG_NLS_MonoExtC_3
Eukaryotic Linear Motif resource motif class TRG_NLS_MonoExtN_4
Armadillo Domain Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Armadillo/plakoglobin ARM repeat in PROSITE

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UpToDate Contents

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1. 原発性両側副腎皮質大結節性過形成によるクッシング症候群 cushings syndrome due to primary bilateral macronodular adrenal hyperplasia
2. サシガメ（オオサシガメ属）による咬傷に対する反応 reactions to bites from kissing bugs primarily genus triatoma
3. スポロトリコーシスの基本的な生物学および疫学 basic biology and epidemiology of sporotrichosis
4. ハンセン病の疫学、微生物学、臨床症状、および診断 epidemiology microbiology clinical manifestations and diagnosis of leprosy
5. パラコクシジオイデス症の菌類学および疫学 mycology and epidemiology of paracoccidioidomycosis

English Journal

Recognition of a structural domain (RWDBD) in Gcn1 proteins that interacts with the RWD domain containing proteins.

Rakesh R1, Krishnan R2, Sattlegger E3, Srinivasan N4.
Biology direct.Biol Direct.2017 May 19;12(1):12. doi: 10.1186/s13062-017-0184-3.
PMID 28526057

The ARM domain of ARMADILLO-REPEAT KINESIN 1 is not required for microtubule catastrophe but can negatively regulate NIMA-RELATED KINASE 6 in Arabidopsis thaliana.

Eng RC1,2, Halat LS1, Livingston SJ1, Sakai T3, Motose H4, Wasteneys G1.
Plant & cell physiology.Plant Cell Physiol.2017 May 13. doi: 10.1093/pcp/pcx070. [Epub ahead of print]
PMID 28505371

Exome-Wide Association Study Identified New Risk Loci for Hirschsprung's Disease.

Tang W1,2, Tang J1,2, Zhao Y1,3, Qin Y1,4, Jin G1,3, Xu X1,2, Zhu H2, Shen H1,3, Wang X1,4, Hu Z5,6, Xia Y7,8.
Molecular neurobiology.Mol Neurobiol.2017 Apr;54(3):1777-1785. doi: 10.1007/s12035-016-9752-2. Epub 2016 Feb 18.
PMID 26887379

Japanese Journal

タンパク質超二次構造のデータマイニング解析

情報化学討論会講演要旨集 2013(0), P11-P11, 2013
NAID 130004730427

Crystal Structure of a PFU-PUL Domain Pair of Saccharomyces Cerevisiae Doa1/Ufd3

The Kobe journal of the medical sciences 56(3), 125-139, 2010
NAID 110009824994

Involvement of p120 Carboxy-Terminal Domain in Cadherin Trafficking

Cell Structure and Function 32(2), 127-137, 2007
NAID 130004137524

Related Pictures

★リンクテーブル★

リンク元	「armadillo motif」
関連記事	「repeat」「repeated」

「armadillo motif」

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Armadillo repeat domain
	Structure of the armadillo domain of beta-catenin.
Identifiers
Symbol	Arm
Pfam	PF00514
Pfam clan	CL0020
InterPro	IPR000225
SMART	SM00185
PROSITE	PS50176
SCOP	3bct
SUPERFAMILY	3bct
CDD	cd00020
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary