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1. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割lipoprotein classification metabolism and role in atherosclerosis [show details]
… triglycerides) onto apolipoprotein (apo) B 100 in the liver . The surface apolipoproteins for VLDL are noted above. They include apo C-II, which acts as a cofactor for lipoprotein lipase; apo C-III, which inhibits this …
2. 第VIII因子および第IX因子の生物学と正常な機能biology and normal function of factor viii and factor ix [show details]
…Factor VIIIa is also cleaved by activated protein C at Arg562 in the A2 subunit. Factor VIII consists of a heavy chain with A1 and A2 domains ; a connecting region with a B domain; and a light chain with …
3. 妊娠糖尿病：産科関連の問題とマネージメントgestational diabetes mellitus obstetric issues and management [show details]
…which generally recommends that women who require insulin or an oral antihyperglycemic agent (ie, class A2 GDM ) to maintain euglycemia or who have poorly controlled blood glucose levels should be managed the …
4. ネフローゼ症候群における脂質異常lipid abnormalities in nephrotic syndrome [show details]
… elevated levels of apo B, C-II, and E, which are associated with VLDL and LDL; on the other hand, the levels of the major apolipoproteins associated with HDL, apo A-I and A-II,… effect include removal of toxic lipids, reduction of the vasoconstrictive prostanoid and thromboxane A2, and reduction of inflammatory cytokines . In the absence of randomized controlled trials, the role…
5. 正常なヘモグロビンの構造および機能structure and function of normal hemoglobins [show details]
… Disorders associated with increased levels of HbF are discussed separately. Hemoglobin A2 – Hemoglobin A2 (HbA2, alpha2/delta2) is a minor hemoglobin throughout fetal and adult life. Its concentration …

English Journal

Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes.

Kheniser KG, Osme A, Kim C, Ilchenko S, Kasumov T, Kashyap SR.
Biomolecules. 2020 Mar;10(4).
We examined the effect of mild hyperglycemia on high-density lipoprotein (HDL) metabolism and kinetics in diet-controlled subjects with type 2 diabetes (T2D). HO-labeling coupled with mass spectrometry was applied to quantify HDL cholesterol turnover and HDL proteome dynamics in subjects with T2D (n
PMID 32235466

The Amniotic Fluid Proteome Differs Significantly between Donor and Recipient Fetuses in Pregnancies Complicated by Twin-to-Twin Transfusion Syndrome.

Kim SM, Cho BK, Kim BJ, Lee HY, Norwitz ER, Kang MJ, Lee SM, Park CW, Jun JK, Yi EC, Park JS.
Journal of Korean medical science. 2020 Mar;35(10)e73.
Twin-to-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. It results from disproportionate blood supply to each fetus caused by abnormal vascular anastomosis within the placenta. Amniotic fluid (AF) is an indicator reflecting the various conditions of the
PMID 32174066

The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.

Baziar N, Nasli-Esfahani E, Djafarian K, Qorbani M, Hedayati M, Mishani MA, Faghfoori Z, Ahmaripour N, Hosseini S.
Oxidative medicine and cellular longevity. 2020 ;2020()5850865.
Lipoprotein-associated phospholipase A (Lp-PLA2) is a new specific vascular inflammation biomarker that is carried by the lipoproteins in the blood and plays a prominent role in the pathogenesis of atherosclerosis. Increased Lp-PLA2 levels and impaired Lp-PLA2 distribution across high-density lipopr
PMID 32256955

Japanese Journal

Rasagiline Pharmacokinetics are affected by cytochrome P-450 1A2 genetic variants in different doses

Bilal Rabiea,Saud Naseem,Riffat Sualeha
日本薬理学会年会要旨集 93(0), 2-O-039, 2020
… To explore the effect of genetic variants of cytochrome P-450 1A2 which is the drug metabolizing enzyme, this study was carried out on total of 108 healthy volunteers. … CC variants of CYP1A2 enzyme. … The plasma concentrations were determined using High performance liquid chromatography and pharmacokinetic variables were calculated using APO Pharmacologica software. …
NAID 130007811549

血液透析患者におけるシロスタゾールの血清脂質に与える影響

大坪茂,矢吹恭子,石原美和,高崎順代,植田修逸,杉本久之,大坪由里子,新田孝作
日本透析医学会雑誌 45(7), 567-570, 2012
… ステロール，Apolipoprotein A1（Apo A-1），Apolipoprotein A2（Apo A-2），Apolipoprotein B（Apo B）を測定した．シロスタゾール切り替え後のHDL-コレステロールは45.8±11.5mg/dLより52.4±12.3mg/dLと有意に上昇した（p＝0.003）．Apo A-1は123.8±21.3mg/dLより139.4±19.1mg/dLと有意に上昇（p＝0.004）し，Apo A-2も26.4±4.3mg/dLより28.9&p …
NAID 130002145580

上部および下部消化管に特異な内視鏡所見を認めたＴａｎｇｉｅｒ病の１例

井上博,伊東進,弘井誠,井上修志,佐藤康紀,福家浩三,面家敏宏,福森信彦,遠藤純子,植村信隆,岸清一郎
日本消化器内視鏡学会雑誌 45(6), 1024-1030, 2003
巨大な胃ポリープを伴うたTangier病の1例を報告する.患者は51歳の女性で易疲労感を主訴に当科を受診した,眼瞼結膜の貧血を認めた.上部消化管内視鏡検査において胃は粘膜全体が黄色調を呈し,巨大なポリープと多数の黄色腫を認め,脂質検査では血清コレステロール値の低下,特にHDLコレステロール(high density lipoprotein-cho1estero1:HDL-Ch),アポリポ蛋白A-1 …
NAID 130004254638