アポリポタンパク質A2
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2020/04/12 14:50:17」(JST)
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apolipoprotein A-II |
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Identifiers |
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Symbol | APOA2 |
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NCBI gene | 336 |
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HGNC | 601 |
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OMIM | 107670 |
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RefSeq | NM_001643 |
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UniProt | P02652 |
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Other data |
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Locus | Chr. 1 q21-q23 |
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Apolipoprotein A-II is an apolipoprotein found in high density lipoprotein (HDL) cholesterol in plasma.
It has an approximate molecular weight 17.4 kDa.[1]
References
- ^ High HDL Cholesterol (Hyperalphalipoproteinemia) at eMedicine
External links
- Apolipoprotein+A-II at the US National Library of Medicine Medical Subject Headings (MeSH)
Lipids: lipoprotein particle metabolism |
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Lipoprotein particle classes and subclasses |
- delivery of TGs: Chylomicron
- VLDL
- delivery of C and CE: IDL
- LDL
- lb LDL
- sd LDL
- Lp(a)
- HDL
- Remnant cholesterol
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Apolipoproteins |
- APOA
- APOB
- APOC
- APOD
- APOE
- APOH
- SAA
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Extracellular enzymes | |
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Lipid transfer proteins | |
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Cell surface receptors |
- IDL: LRP
- LRP1
- LRP1B
- LRP2
- LRP3
- LRP4
- LRP5
- LRP5L
- LRP6
- LRP8
- LRP10
- LRP11
- LRP12
- LDL: LDLR
- LRPAP1
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ATP-binding cassette transporter | |
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UpToDate Contents
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- 1. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割lipoprotein classification metabolism and role in atherosclerosis [show details]
…the different apolipoproteins is important clinically, because defects in apolipoprotein metabolism lead to abnormalities in lipid handling . The assembly and secretion of apolipoprotein B-containing …
- 2. 成人の家族性高コレステロール血症:概要familial hypercholesterolemia in adults overview [show details]
…gain-of-function mutations of the proprotein convertase subtilisin kexin 9 gene (PCSK9), and the apolipoprotein B gene (principally APOB3500) Each of these three mutations impairs LDL receptor-mediated catabolism …
- 3. アミロイドーシスの概要overview of amyloidosis [show details]
…common in AA and AL amyloidosis, but is rare in ATTR; LECT2, fibrinogen A-alpha chain, and apolipoproteins A1, A2, and A4 are rarer causes of nephropathic amyloidosis worldwide . However, familial or sporadic …
- 4. アミロイド疾患の遺伝的要因genetic factors in the amyloid diseases [show details]
…P-component (SAP, a member of the pentraxin family that includes C-reactive protein) Specific apolipoproteins (E and J) Cofactors, including molecular chaperones and proteases, may significantly modulate …
- 5. 成人の肺胞蛋白症の原因、臨床症状、診断causes clinical manifestations and diagnosis of pulmonary alveolar proteinosis in adults [show details]
…preserved. The lipoproteinaceous material is composed principally of surfactant phospholipid and apoproteins. The etiology, pathogenesis, clinical manifestations, and diagnosis of PAP in adults will be reviewed …
English Journal
- Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes.
- Kheniser KG, Osme A, Kim C, Ilchenko S, Kasumov T, Kashyap SR.
- Biomolecules. 2020 Mar;10(4).
- We examined the effect of mild hyperglycemia on high-density lipoprotein (HDL) metabolism and kinetics in diet-controlled subjects with type 2 diabetes (T2D). HO-labeling coupled with mass spectrometry was applied to quantify HDL cholesterol turnover and HDL proteome dynamics in subjects with T2D (n
- PMID 32235466
- The Amniotic Fluid Proteome Differs Significantly between Donor and Recipient Fetuses in Pregnancies Complicated by Twin-to-Twin Transfusion Syndrome.
- Kim SM, Cho BK, Kim BJ, Lee HY, Norwitz ER, Kang MJ, Lee SM, Park CW, Jun JK, Yi EC, Park JS.
- Journal of Korean medical science. 2020 Mar;35(10)e73.
- Twin-to-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. It results from disproportionate blood supply to each fetus caused by abnormal vascular anastomosis within the placenta. Amniotic fluid (AF) is an indicator reflecting the various conditions of the
- PMID 32174066
- The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Baziar N, Nasli-Esfahani E, Djafarian K, Qorbani M, Hedayati M, Mishani MA, Faghfoori Z, Ahmaripour N, Hosseini S.
- Oxidative medicine and cellular longevity. 2020 ;2020()5850865.
- Lipoprotein-associated phospholipase A (Lp-PLA2) is a new specific vascular inflammation biomarker that is carried by the lipoproteins in the blood and plays a prominent role in the pathogenesis of atherosclerosis. Increased Lp-PLA2 levels and impaired Lp-PLA2 distribution across high-density lipopr
- PMID 32256955
Japanese Journal
- 林 秀樹,森 みすず,山田 まりこ,袁 博,高木 教夫
- 日本薬理学会年会要旨集 92(0), 3-O-06, 2019
- … <p>Apolipoprotein E-containing lipoproteins (E-LPs) have crucial roles of lipid transport in the central nervous system. … α2-Macroglobulin (a2M) is a pan-protease inhibitor found in plasma and cerebrospinal fluid. … It has been reported that a2M is increased in aqueous humor of glaucoma patients. … Intravitreal administration of E-LPs also attenuated the elevated a2M level in aqueous humor of the glaucoma model. …
- NAID 130007813214
- 血中アポリポ蛋白A2アイソフォーム測定による膵がん検診の可能性
- 小林 隆,佐藤 悠,西海 信,岡谷 しのぶ,吉田 優,児玉 裕三,長島 健悟,本田 一文
- 日本分子腫瘍マーカー研究会誌 34(0), 59-60, 2019
- NAID 130007555625
- Serum apolipoprotein A2 isoforms in autoimmune pancreatitis
- Kobayashi Takashi,Sato Yu,Nishiumi Shin,Yagi Yosuke,Sakai Arata,Shiomi Hideyuki,Masuda Atsuhiro,Okaya Shinobu,Kutsumi Hiromu,Yoshida Masaru,Honda Kazufumi
- Biochemical and Biophysical Research Communications 497(3), 903-907, 2018-03-11
- … Recently, apolipoprotein A2 (apoA2) isoforms have been reported as candidate serum/plasma biomarkers of pancreatic cancer. …
- NAID 120006604668
Related Links
- Human apolipoprotein A-II inhibits the production of interferon-gamma by concanavalin A-stimulated mouse and human CD4-positive T cells. Low apolipoprotein-A2 is associated with metastatic renal cell cancer.
- アポリポタンパクA2(APOA2)について アポリポタンパクA2(以下、APOA2と略す)は前述の通り、APOA1と共にHDLを構成する主要タンパク質の一つです。APOA2は主に肝臓や小腸で産生され、末梢血中に大量に存在しています。
- Honda K, Srivastava S. Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer. Biomark Med. 2016 Nov;10(11):1197-1207. Honda K, Kobayashi M, et al. Plasma biomarker for ...
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