WordNet

a substance that exerts some force or effect
a businessman who buys or sells for another in exchange for a commission (同)factor, broker
any agent or representative of a federal agency or bureau (同)federal agent
a representative who acts on behalf of other persons or organizations
an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"

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Sustained Inhibition of Proliferative Response After Transient FGF Stimulation Is Mediated by Interleukin 1 Signaling.

Poole A1, Kacer D1, Cooper E1, Tarantini F2, Prudovsky I1.
Journal of cellular physiology.J Cell Physiol.2016 Mar;231(3):650-8. doi: 10.1002/jcp.25111.
Transient FGF stimulation of various cell types results in FGF memory-a sustained blockage of efficient proliferative response to FGF and other growth factors. FGF memory establishment requires HDAC activity, indicating its epigenetic character. FGF treatment stimulates proinflammatory NFκB signali
PMID 26218437

The Effects of Clinically Relevant Hypertonic Saline and Conivaptan Administration on Ischemic Stroke.

Decker D1, Collier L2, Lau T1, Olivera R1, Roma G2, Leonardo C2, Seifert H2, Rowe D2, Pennypacker KR3.
Acta neurochirurgica. Supplement.Acta Neurochir Suppl.2016;121:243-50. doi: 10.1007/978-3-319-18497-5_43.
Cerebral edema after stroke is associated with poor neurological outcomes. Current therapies are limited to osmotic agents, such as hypertonic saline (HS), which reduce intracranial pressure. Although studies have demonstrated edema reductions following HS, tissue survival has not been thoroughly ex
PMID 26463956

Uy HS, Yu-Keh E, Chan PS.
Developments in ophthalmology.Dev Ophthalmol.2016;55:163-6. doi: 10.1159/000438968. Epub 2015 Oct 26.
Posterior uveitis is a major cause of ocular morbidity worldwide. Systemic corticosteroids (CS) remain the primary method of treatment for noninfectious posterior uveitis; however, CS are associated with many side effects. Immunomodulatory therapy (IMT) is recommended when inflammatory control is no
PMID 26502276

奥山聡
薬学雑誌. 乙号 135(10), 1153-1159, 2015
… AUR also showed antiinflammatory effects on the ischemic brain by inhibiting microglial activation, COX-2 expression, and neuronal cell death in the hippocampus. … The dried powder of both the peel and juice had antiinflammatory effects in the mouse hippocampus, suggesting that citrus compounds may be beneficial as neuroprotective agents in the treatment of neurological disorders. …
NAID 130005100623

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Gu Ronghui,Wang Yuehu,Long Bo,Kennelly Edward,Wu Shibiao,Liu Bo,Li Ping,Long Chunlin
Biological and Pharmaceutical Bulletin 37(6), 903-915, 2014
… Pharmacologically active constituents from traditional medicinal plants have received great attention as sources of novel agents, pharmaceutical intermediates, and chemical entities for synthetic or semisynthetic drugs due to their potent pharmacological activities, low toxicity, and economic viability. …
NAID 130004147349

Analysis of cytotoxicity induced by proinflammatory cytokines in the human alveolar epithelial cell line A549

Muroya Mitsuaki,Chang Kyungho,Uchida Kanji,Bougaki Masahiko,Yamada Yoshitsugu
BioScience Trends 6(2), 70-80, 2012
… To estimate the cytotoxic signaling pathways responsible for epithelial injury, agents with antiinflammatory or antioxidative properties were extensively screened for cytoprotective effects in the inflammation-associated epithelial injury model. …
NAID 130004572568