抗グルタミン酸脱炭酸酵素抗体
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- 1. 1型糖尿病の予測prediction of type 1 diabetes mellitus [show details]
…cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GAD), antibodies to tyrosine phosphatase-like proteins such as insulinoma-associated protein (IA-2, ICA512) …
- 2. 糖尿病および遺伝的糖尿病症候群の分類classification of diabetes mellitus and genetic diabetic syndromes [show details]
…likelihood of a positive value, but it is also more costly. Two (ie, islet cell and GAD65) or three (insulin, GAD65, and IA-2 or GAD65, IA-2, and ZnT8) antibodies can be measured. Insulin antibodies should not …
- 3. スティッフパーソン症候群stiff person syndrome [show details]
…SPS have anti-GAD antibodies recognizing discontinuous segments of the middle and C-terminal part of GAD65, which represents epitopes influenced by molecular conformation . Anti-GAD antibodies are positive …
- 4. 成人における小脳性運動失調の概要overview of cerebellar ataxia in adults [show details]
…including acute disseminated encephalomyelitis, celiac disease (gluten enteropathy with ataxia), GAD antibody-associated ataxia, Hashimoto thyroiditis/encephalopathy, Histiocytosis X, the Miller Fisher variant …
- 5. 1型糖尿病の予防prevention of type 1 diabetes mellitus [show details]
…could be specifically targeted for destruction. Glutamic acid decarboxylase, 65 kilodalton isoform (GAD65), is a major autoantigen in patients with type 1 diabetes . When administered by injection in the …
English Journal
- Anti-glutamic acid decarboxylase (GAD) positive cerebellar Ataxia with transitioning to progressive encephalomyelitis with rigidity and myoclonus (PERM), responsive to immunotherapy: A case report and review of literature.
- Jazebi N, Rodrigo S, Gogia B, Shawagfeh A.
- Journal of neuroimmunology. 2019 Jul;332()135-137.
- We present a case of a 65-year-old African American male, immunosuppressed on Tacrolimus, who initially presented with cerebellar ataxia and rapidly developed Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with positive anti-glutamic acid decarboxylase (GAD65) antibodies, no underl
- PMID 31015081
- Complex phenotype in a C9ORF72-positive patient with high-titer anti-glutamic acid decarboxylase antibodies: neuroimmunology meets neurogenetics.
- Varvaressos S, Breza M, Marousi S, Printzou M, Georgoulis A, Papageorgiou E, Kartanou C, Karadima G, Tagaris G, Koutsis G, Tzartos JS.
- European journal of neurology. 2019 Jul;26(7)e73-e74.
- PMID 31059159
- [A Case of Flexion Contracture Associated with Hypopituitarism].
- Kitanosono H, Shiraishi H, Nagaoka A, Yoshimura S, Nakajima Y, Imaizumi M, Ando T, Tsujino A.
- Brain and nerve = Shinkei kenkyu no shinpo. 2019 Jun;71(6)617-621.
- A 72-year-old Japanese man developed progressive disturbance in ambulation with flexion contractures 5years before this admission. At 49 years of age, he was diagnosed with hypopituitarism after an operation for a Rathke's cleft. On admission, he could not fully extend his knees and hips because of
- PMID 31171759
Japanese Journal
- Clinical characteristics of anti-glutamic acid decarboxylase antibody-positive fulminant type 1 diabetes
- Saito Daigo,Oikawa Yoichi,Mizutani Gen,Inoue Kazuyuki,Hatano Masako,Inoue Ikuo,Noda Mitsuhiko,Shimada Akira
- Endocrine Journal 66(4), 329-336, 2019
- … <p>This research aimed to examine the relationship between anti-glutamic acid decarboxylase antibody (GADA) titers and clinical parameters at onset and to clarify the association between clinical severity and GADA titers in GADA-positive fulminant type 1 diabetes. …
- NAID 130007636462
- Clinical characteristics of anti-glutamic acid decarboxylase antibody-positive fulminant type 1 diabetes
- Saito Daigo,Oikawa Yoichi,Mizutani Gen,Inoue Kazuyuki,Hatano Masako,Inoue Ikuo,Noda Mitsuhiko,Shimada Akira
- Endocrine Journal, 2019
- … <p>This research aimed to examine the relationship between anti-glutamic acid decarboxylase antibody (GADA) titers and clinical parameters at onset and to clarify the association between clinical severity and GADA titers in GADA-positive fulminant type 1 diabetes. …
- NAID 130007591250
- 抗PD-1抗体投与後に発症する1型糖尿病の特徴および臨床経過に関する調査報告
- 馬殿 恵,川﨑 英二,川畑 由美子,小澤 純二,島田 朗,高橋 和眞,田中 昌一郎,中條 大輔,福井 智康,三浦 順之助,安田 和基,今川 彰久,安田 尚史,小林 哲郎,花房 俊昭,日本人1型糖尿病の成因，診断，病態，治療に関する調査研究委員会,阿比留 教生,粟田 卓也,池上 博司,内潟 安子,及川 洋一,大澤 春彦,梶尾 裕
- 糖尿病 62(1), 37-46, 2019
- <p>抗PD-1抗体投与後に発症する1型糖尿病について，日本糖尿病学会員への調査と文献検索を行い22症例を検討した．初回の薬剤投与日から発症までの平均期間は155日，発症時の平均年齢63歳，平均血糖値617 mg/dL，平均HbA1c8.1 %，尿中C-ペプチド4.1 <i>μ</i>g/日（中央値），空腹時血中C-ペプチド0.46 ng/mL（中央値）であった …
- NAID 130007584372
Related Links
- Antibodies specific for glutamic acid decarboxylase (GAD65) account for most, but not all, antibodies detected in the islet cell antibody test (IA-2). IA-2 (a protein tyrosine kinase-like protein) insulin and zinc transporter-8 antibodies ...
- GD65S : Assessing susceptibility to autoimmune (type 1, insulin-dependent) diabetes mellitus and related endocrine disorders (eg, thyroiditis and pernicious anemia). Titers generally < or =0.02 nmol/L. A second islet cell antibody ...
- Mouse anti Human Glutamate Decarboxylase 2 (N-Terminal) antibody, clone N-GAD65 recognizes human glutamate decarboxylase 2, also known as 65 kDa glutamic acid decarboxylase, Glutamate decarboxylase 65 kDa isoform or ...
★リンクテーブル★
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- 英
- anti-glutamic acid decarboxylase antibody
- 同
- 抗GAD抗体、GAD抗体
- 関
- グルタミン酸脱炭酸酵素
意義
基準範囲
1型糖尿病
- 一緒に空腹時の血清Cペプチドもはかり、0.5ng/ml未満であればインスリン依存状態である。
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- 英
- glutamate decarboxylase
- 同
- グルタミン酸デカルボキシラーゼ
- 関
- 抗グルタミン酸脱炭酸酵素抗体 anti-glutamic acid decarboxylase antibody
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- 関
- E、Glu、glutamate、glutamic acid、L-glutamic acid
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デカルボキシラーゼ、脱炭酸酵素
- 関
- carboxy-lyase
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- 同
- ants, stinging
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