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Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells.

McNeill A1, Magalhaes J, Shen C, Chau KY, Hughes D, Mehta A, Foltynie T, Cooper JM, Abramov AY, Gegg M, Schapira AH.
Brain : a journal of neurology.Brain.2014 May;137(Pt 5):1481-95. doi: 10.1093/brain/awu020. Epub 2014 Feb 25.
Gaucher disease is caused by mutations in the glucocerebrosidase gene, which encodes the lysosomal hydrolase glucosylceramidase. Patients with Gaucher disease and heterozygous glucocerebrosidase mutation carriers are at increased risk of developing Parkinson's disease. Indeed, glucocerebrosidase mut
PMID 24574503

Ambroxol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells.

Yamaya M1, Nishimura H, Nadine LK, Ota C, Kubo H, Nagatomi R.
Archives of pharmacal research.Arch Pharm Res.2014 Apr;37(4):520-9. doi: 10.1007/s12272-013-0210-7. Epub 2013 Jul 16.
The mucolytic drug ambroxol hydrochloride reduces the production of pro-inflammatory cytokines and the frequency of exacerbation in patients with chronic obstructive pulmonary disease (COPD). However, the inhibitory effects of ambroxol on rhinovirus infection, the major cause of COPD exacerbations,
PMID 23856970

Effects of fengbaisan on the expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung tissue of rats with chronic obstructive pulmonary disease.

Wang Y1, Su NX, Chen ZQ, Wang Z, Zhang SF.
Chinese journal of integrative medicine.Chin J Integr Med.2014 Mar;20(3):224-31. doi: 10.1007/s11655-013-1619-z. Epub 2013 Nov 16.
OBJECTIVE: To observe effects of Fengbaisan (, FBS) on the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in lung tissue of rats with chronic obstructive pulmonary disease (COPD) and to investigate the preventive and therapeutic mechanisms of FB
PMID 24242136

A case of skin eruption due to ambroxol hydrochloride except for the site of radiation therapy

TERASAKI Kenjiro,HOZUMI Hideki,KANZAKI Tamotsu
Environmental dermatology : the official journal of the Japanese Society for Contact Dermatitis 9(2), 70-73, 2002-04-01
NAID 10013245995

石橋祐二,岡村孝夫,益本吉廣,建入徳栄,百々研次郎
日本呼吸器学会雑誌 = The journal of the Japanese Respiratory Society 39(1), 17-23, 2001-01-10
NAID 10006830171

上田直之,竹野幸夫,陳九宏,長田理加,川本浩子,福島典之,夜陣紘治
耳鼻咽喉科臨床 93(2), 167-173, 2000-02-01
… We further examined actions of ambroxol hydrochloride, a mucolytic agent with cilioregulatory and antioxidant effects, in cytokine-induced cilioinhibition. … Ambroxol at concentrations of 10-4M and 10-5M both increased CBF by 8.1% (p<0.01) and 13.5% (p<0.01), respectively. … The cilioinhibitory effects of TNF-aplha and IFN-gamma were canceled by treating specimens with 10-4M of ambroxol. …
NAID 10005599675