alternative RNA splicing

• 選択的RNAスプライシング

関

alternate splicing、alternative splicing

WordNet

1. pertaining to unconventional choices; "an alternative life style"
2. necessitating a choice between mutually exclusive possibilities; "alternative possibilities were neutrality or war"
3. the 18th letter of the Roman alphabet (同)r

PrepTutorEJDIC

1. (二つのうち)『どちらかを選ぶべき』,二者択一の / 代わりの / 反体制的な,現在の社会と違った価値体系を持った / 二つのものの一つを選ぶこと,二者択一 / (二者のうち)選ぶべき一方 / 代わりのもの;他にとりうる方法
2. resistance / 17歳以下父兄同伴映画の表示 / rook
3. ribonucleic acid・リボ核酸

UpToDate Contents

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• 1. 喘息におけるステロイド耐性のメカニズムおよび 臨床的意義mechanisms and clinical implications of glucocorticoid resistance in asthma [show details]
  …Tth111I polymorphism in severe asthmatics with an Asthma Control Test (ACT) score ≥20. Alternative splicing of GR RNA can produce C-terminal isoforms termed GC receptor-alpha (GRalpha) and GC receptor-beta …
• 2. 遺伝学およびゲノミクスのためのツール：遺伝子発現プロファイリングtools for genetics and genomics gene expression profiling [show details]
  … for more advanced analyses, such as discovery of novel transcripts or isoforms, detection of alternative splicing, and de novo reconstruction of the transcriptome . Single cell RNAseq (scRNAseq) enables … An alternative for measuring gene expression is the direct sequencing and quantification of RNA molecules. This method of measuring gene expression has also been referred to as "RNA-seq,"…
• 3. 遺伝学：用語集genetics glossary of terms [show details]
  … RNA, or protein) with two or more states. Protein polymorphisms (varying amino acid sequence) can result from DNA polymorphisms or from differential RNA splicing (different… An allele is one of a series of alternative forms (genotypes) at locus,…
• 4. サラセミア症候群の分子遺伝学的特性molecular genetics of the thalassemia syndromes [show details]
  …coding for globin messenger RNA (mRNA). The exons are separated by two introns, which are transcribed into the mRNA precursor but subsequently excised by pre-mRNA splicing. Splicing knits the exons together …
• 5. 骨髄異形成症候群における細胞遺伝学および分子遺伝学cytogenetics and molecular genetics of myelodysplastic syndromes [show details]
  …for assembly of the spliceosome, selection of the correct splice-sites, and constitutive and alternative RNA splicing during the processing of precursor mRNA to mature mRNA. Mutations of SRSF2 are detected …

English Journal

• Regulation and Functional Implications of Opioid Receptor Splicing in Opioid Pharmacology and HIV Pathogenesis.

• Regan PM1, Langford D1, Khalili K1.
• Journal of cellular physiology.J Cell Physiol.2016 May;231(5):976-85. doi: 10.1002/jcp.25237. Epub 2015 Nov 24.
• Despite the identification and characterization of four opioid receptor subtypes and the genes from which they are encoded, pharmacological data does not conform to the predications of a four opioid receptor model. Instead, current studies of opioid pharmacology suggest the existence of additional r
• PMID 26529364

• Identification of novel isoforms of dairy goat EEF1D and their mRNA expression characterization.

• Zhang S1, Wu X2, Pan C3, Lei C3, Dang R3, Chen H3, Lan X4.
• Gene.Gene.2016 Apr 25;581(1):14-20. doi: 10.1016/j.gene.2016.01.013. Epub 2016 Jan 12.
• Eukaryotic translation elongation factor 1 delta (EEF1D) gene encodes guanine nucleotide exchange protein eEF1Bδ, which participates in the eukaryotic protein synthesis, and plays important roles in regulating cell cycling and milk production. This study firstly focused on detecting the isoforms of
• PMID 26794801

• Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing.

• Huertas CS1, Carrascosa LG1, Bonnal S2, Valcárcel J3, Lechuga LM4.
• Biosensors & bioelectronics.Biosens Bioelectron.2016 Apr 15;78:118-25. doi: 10.1016/j.bios.2015.11.023. Epub 2015 Nov 10.
• Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. Its deregulation is strongly linked to disease onset and progression. Current methodologies for monitoring alternative splicing deman
• PMID 26599481

Japanese Journal

• Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen

• Depledge Daniel P.,Srinivas Kalanghad Puthankalam,Sadaoka Tomohiko,Bready Devin,Mori Yasuko,Placantonakis Dimitris G.,Mohr Ian,Wilson Angus C.
• Nature Communications (10), 754, 2019-02-14
• … Characterizing complex viral transcriptomes by conventional RNA sequencing approaches is complicated by high gene density, overlapping reading frames, and complex splicing patterns. … Direct RNA sequencing (direct RNA-seq) using nanopore arrays offers an exciting alternative whereby individual polyadenylated RNAs are sequenced directly, without the recoding and amplification biases inherent to other sequencing methodologies. …
• NAID 120006559317

• PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia

• SENOO Manami,TAKIJIRI Takashi,YOSHIDA Nobuaki,OZAWA Manabu,IKAWA Masahito
• 家畜繁殖学雑誌 65(1), 37-46, 2019
• … Polypyrimidine tract-binding protein 1 (PTBP1) is a highly conserved RNA-binding protein that is a well-known regulator of alternative splicing. … Testicular tissue is one of the richest tissues with respect to the number of alternative splicing mRNA isoforms, but the molecular role(s) of PTBP1 in the regulation of these isoforms during spermatogenesis is still unclear. …
• NAID 130007594357

• PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopathy and Reveals Cryptic Alternative Splicing Products

• 深水 昭吉,村谷 匡史,村田 知弥,石田 純治,Masafumi MURATANI,Weizhe Lu,Misuzu Hashimoto,Natsumi Ono,Kazuya MURATA,Kana Nishikata,Jun-Dal Kim,Shizufumi Ebihara,Junji ISHIDA,Akiyoshi FUKAMIZU
• iScience (8), 200-213, 2018-10
• … Protein arginine methyltransferase 1 (PRMT1) catalyzes the asymmetric dimethylation of arginine residues in proteins and methylation of various RNA-binding proteins and is associated with alternative splicing in vitro. … Here, we report that juvenile cardiomyocyte-specific PRMT1-deficient mice develop severe dilated cardiomyopathy and exhibit aberrant cardiac alternative splicing. …
• NAID 120006582711

Related Links

• Alternative RNA splicing | Diaxonhit - Diaxonhit | Specialty ...

RNA splicing is an essential and precisely regulated post-transcriptional process that occurs prior to mRNA translation. It is thought that at least 70% of the approximately 25,000 genes in the human genome undergo alternative ...

• Alternative RNA Splicing :: DNA Learning Center

Phil Sharp: Many genes in our body are expressed as RNA in different cell types, a skin cell, a bone cell, a brain cell. But in one cell type, the pattern of ... 16948. Alternative RNA Splicing Therapy for Spinal Muscular Atrophy Drs ...

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★リンクテーブル★

リンク元	「alternate splicing」「選択的RNAスプライシング」
関連記事	「alternative」「R」「RNA」「alternatives」

「alternate splicing」

　　[★] 選択的スプライシング

• 一つの遺伝子からイントロン除去部位の違いにより異なる複数のタンパク質が生成する現象

関

alternative RNA splicing、alternative splicing

「選択的RNAスプライシング」

　　[★]

英

alternative RNA splicing

関

選択的スプライシング

「alternative」

　　[★]

• adj.

• 代替の、二者択一の、別の、オルタナティブな、アルタナティブな

• n.

• 代替物

関

alternatively、alternatives、otherwise、substitution、surrogate

　 　 　

「R」

　　[★]

• レントゲン roentgen
• アルギニン
• respiratory rate
• respiratory quotient
• プリン
• アルキル基 alkyl group
• 化合物の側鎖

　 　

「RNA」

　　[★]

同

リボ核酸 ribonucleic acid RNA

関

DNA

• D-リボースを糖成分とする核酸

　

「alternatives」

　　[★]

代替物

関

alternative