Alginic acid
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| Names |
| Other names
Alginic acid, E400
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| Identifiers |
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CAS Number
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| ChemSpider |
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| ECHA InfoCard |
100.029.697 |
| EC Number |
232-680-1 |
| E number |
E400 (thickeners, ...) |
| UNII |
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| Properties |
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Chemical formula
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(C6H8O6)n |
| Molar mass |
10,000 – 600,000 |
| Appearance |
white to yellow, fibrous powder |
| Density |
1.601 g/cm3 |
| Acidity (pKa) |
1.5–3.5 |
| Pharmacology |
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ATC code
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A02BX13 (WHO) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| N verify (what is YN ?) |
| Infobox references |
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Macrocystis pyrifera, the largest species of giant kelp
Alginic acid, also called algin or alginate, is an anionic polysaccharide distributed widely in the cell walls of brown algae, where through binding with water it forms a viscous gum. It is also a significant component of the biofilms produced by the bacterium Pseudomonas aeruginosa, the major pathogen in cystic fibrosis,[1] that confer it a high resistance to antibiotics[2] and killing by macrophages.[3] Its colour ranges from white to yellowish-brown. It is sold in filamentous, granular or powdered forms.
Contents
- 1 Structure
- 2 Forms
- 3 Production
- 4 Uses
- 5 Alginate hydrogels
- 6 See also
- 7 References
- 8 External links
Structure
Alginic acid is a linear copolymer with homopolymeric blocks of (1-4)-linked β-D-mannuronate (M) and its C-5 epimer α-L-guluronate (G) residues, respectively, covalently linked together in different sequences or blocks. The monomers can appear in homopolymeric blocks of consecutive G-residues (G-blocks), consecutive M-residues (M-blocks) or alternating M and G-residues (MG-blocks).
Forms
Alginates are refined from brown seaweeds. A wide variety of brown seaweeds of the phylum Phaeophyceae are harvested throughout the world to be converted into the raw material commonly known as sodium alginate. Sodium alginate has a wide use across a wide variety of industries including food, textile printing and pharmaceutical. Dental impression material utilizes alginate as its means of gelling. Alginate is both food and skin safe.
Seaweeds can be classified into three broad groups based on pigmentation: brown, red and green. These broad groups are the Phaeophyceae, Rhodophyceae and Chlorophyceae, respectively. Brown seaweeds are usually large, and range from the giant kelp Macrocystis pyrifera that is often 20 m long, to thick, leather-like seaweeds from 2-4 m long, to smaller species 30–60 cm long. None of the usual seaweeds for alginate production are cultivated. They cannot be grown by vegetative means, but must go through a reproductive cycle involving an alternation of generations. This makes cultivated brown seaweeds too expensive when compared to the costs of harvesting and transporting wild seaweeds. The only exception is for Laminaria japonica, which is cultivated in China for food but the surplus material is diverted to the alginate industry in China.
Alginates from different species of brown seaweed often have variations in their chemical structure, resulting in different physical properties. For example, some may yield an alginate that gives a strong gel, another a weaker gel; some may readily give a cream/white alginate, while others are difficult to gel, and are best used for technical applications where color does not matter.[4]
Commercial varieties of alginate are extracted from seaweed, including the giant kelp Macrocystis pyrifera, Ascophyllum nodosum, and various types of Laminaria. It is also produced by two bacterial genera Pseudomonas and Azotobacter, which played a major role in the unravelling of its biosynthesis pathway. Bacterial alginates are useful for the production of micro- or nanostructures suitable for medical applications.[5]
Sodium alginate is the sodium salt of alginic acid. Its empirical formula is NaC6H7O6. Sodium alginate is a gum, extracted from the cell walls of brown algae.
Potassium alginate is a chemical compound that is the potassium salt of alginic acid. It is an extract of seaweed. Its empirical chemical formula is KC6H7O6.
Calcium alginate, made from sodium alginate from which the sodium ion has been removed and replaced with calcium, has the chemical formula C12H14CaO12.
Production
The processes for the manufacture of sodium alginate from brown seaweeds fall into two categories: 1) Calcium alginate method and, 2) Alginic acid method. The chemistry of the processes used to make sodium alginate from brown seaweeds is relatively simple. The difficulties of the processes arise from the physical separations which are required, such as the need to filter slimy residues from viscous solutions or to separate gelatinous precipitates which hold large amounts of liquid within the structure and which resist filtration and centrifugation.[6]
Uses
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Alginate absorbs water quickly, which makes it useful as an additive in dehydrated products such as slimming aids, and in the manufacture of paper and textiles. It is also used for waterproofing and fireproofing fabrics, in the food industry as a thickening agent for drinks, ice cream and cosmetics, and as a gelling agent for jellies.[citation needed]
Alginate is used as an ingredient in various pharmaceutical preparations, such as Gaviscon, in which it combines with bicarbonate to inhibit reflux. Sodium alginate is used as an impression-making material in dentistry, prosthetics, lifecasting and for creating positives for small-scale casting.
Sodium alginate is used in reactive dye printing and as a thickener for reactive dyes in textile screen-printing.[citation needed] Alginates do not react with these dyes and wash out easily, unlike starch-based thickeners.
As a material for micro-encapsulation.[7]
Calcium alginate is used in different types of medical products including skin wound dressings to promote healing[8] and can be removed with less pain than conventional dressings.[citation needed]
Alginate hydrogels
Alginate may be used in a hydrogel consisting of microparticles or bulk gels combined with nerve growth factor in bioengineering research to stimulate brain tissue for possible regeneration.[9] In research on bone reconstruction, alginate composites have favorable properties encouraging regeneration, such as improved porosity, cell proliferation, and mechanical strength, among other factors.[10]
See also
- Hyaluronic acid: a polysaccharide in animals.
- Agar
References
- ^ Davies JC Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence. Paediatr Respir Rev. 2002 Jun;3(2):128-34. PMID 12297059
- ^ Boyd A, Chakrabarty AM. Pseudomonas aeruginosa biofilms: role of the alginate exopolysaccharide. J Ind Microbiol. 1995 Sep;15(3):162-8. PMID 8519473
- ^ Leid JG, et al. The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing. J Immunol. 2005 Dec 1;175(11):7512-8. PMID 16301659 Free full text
- ^ FAO FISHERIES TECHNICAL PAPER 441,Tevita Bainiloga Jnr, School of Chemistry, University College, University of New South Wales and Australian Defence Force Academy Canberra Australia
- ^ Remminghorst and Rehm (2009). "Microbial Production of Alginate: Biosynthesis and Applications". Microbial Production of Biopolymers and Polymer Precursors. Caister Academic Press. ISBN 978-1-904455-36-3.
- ^ FAO Fisheries Technical Paper, 2003
- ^ Aizpurua-Olaizola, Oier; Navarro, Patricia; Vallejo, Asier; Olivares, Maitane; Etxebarria, Nestor; Usobiaga, Aresatz (2016-01-01). "Microencapsulation and storage stability of polyphenols from Vitis vinifera grape wastes". Food Chemistry. 190: 614–621. doi:10.1016/j.foodchem.2015.05.117.
- ^ Lansdown AB (2002). "Calcium: a potential central regulator in wound healing in the skin". Wound Repair Regen. 10 (5): 271–85. PMID 12406163. doi:10.1046/j.1524-475x.2002.10502.x.
- ^ Büyüköz, M.; Erdal, E.; Altinkaya, S.A. (2016). "Nanofibrous gelatin scaffolds integrated with NGF-loaded alginate microspheres for brain tissue engineering". J. Tissue Eng. Regen. Med. doi:10.1002/term.2353.
- ^ Venkatesan, J; Bhatnagar, I; Manivasagan, P; Kang, K. H.; Kim, S. K. (2015). "Alginate composites for bone tissue engineering: A review". International Journal of Biological Macromolecules. 72: 269–81. PMID 25020082. doi:10.1016/j.ijbiomac.2014.07.008.
External links
- Alginate seaweed sources
- Alginate properties
- Alginate medical uses
- article Wired on Easy Cheese, describing sodium alginate
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Drugs for peptic ulcer and GERD/GORD (A02B)
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| H2 antagonists ("-tidine") |
- Cimetidine
- Famotidine
- Lafutidine
- Lavoltidine (loxtidine)
- Niperotidine
- Nizatidine
- Ranitidine
- Roxatidine
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| Prostaglandins (E)/analogues ("-prost-") |
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| Proton-pump inhibitors ("-prazole") |
- Azeloprazole
- Dexlansoprazole
- Esomeprazole
- Ilaprazole
- Lansoprazole
- Omeprazole
- Pantoprazole
- Picoprazole
- Rabeprazole
- Tenatoprazole
- Timoprazole
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| Potassium-competitive acid blockers ("-prazan") |
- Linaprazan
- Revaprazan
- Soraprazan
- Vonoprazan
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| Others |
- Aceglutamide aluminum
- Acetoxolone
- Alginic acid
- Arbaclofen placarbil
- Carbenoxolone
- Cetraxate
- Gefarnate
- Lesogaberan
- Pirenzepine
- Proglumide
- Rebamipide
- Sucralfate
- Sulglicotide
- Telenzepine
- Teprenone
- Troxipide
- Zinc L-carnosine
- Zolimidine
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| Combinations |
- Bismuth subcitrate/metronidazole/tetracycline
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- See also: Helicobacter pylori eradication protocols
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