WordNet
- a fibrous band of scar tissue that binds together normally separate anatomical structures
- abnormal union of bodily tissues; most common in the abdomen
- (pathology) a small abnormal patch on or inside the body
PrepTutorEJDIC
- 粘着,付着
- (金属・陶器などの)飾り額,飾り板
UpToDate Contents
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- 1. 不安定プラークの病理および病因 pathology and pathogenesis of the vulnerable plaque
- 2. 急性冠症候群における不安定プラークの役割 the role of the vulnerable plaque in acute coronary syndromes
- 3. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
- 4. アテローム性動脈硬化症の病因 pathogenesis of atherosclerosis
- 5. 冠動脈疾患患者における脂質低下薬の利益の機序 mechanisms of benefit of lipid lowering drugs in patients with coronary heart disease
English Journal
- Inhibition of biofilm formation and antibacterial properties of a silver nano-coating on human dentine.
- Besinis A, De Peralta T, Handy RD.Author information School of Biomedical and Biological Sciences, The University of Plymouth , Plymouth PL4 8AA , UK.AbstractAbstract The survival of pathogenic bacteria in the oral cavity depends on their successful adhesion to dental surfaces and their ability to develop into biofilms, known as dental plaque. Bacteria from the dental plaque are responsible for the development of dental caries, gingivitis, periodontitis, stomatitis and peri-implantitis. Certain metal nanoparticles have been suggested for infection control and the management of the oral biofilm. Here, it is shown that application of a silver nano-coating directly on dentine can successfully prevent the biofilm formation on dentine surfaces as well as inhibit bacterial growth in the surrounding media. This silver nano-coating was found to be stable (>98.8%) and to maintain its integrity in biological fluids. Its antibacterial activity was compared to silver nitrate and the widely used clinical antiseptic, chlorhexidine. The bacterial growth and cell viability were quantitatively assessed by measuring the turbidity, proportion of live and dead cells and lactate production. All three bioassays showed that silver nanoparticles and silver nitrate dentine coatings were equally highly bactericidal (>99.5%), while inhibiting bacterial adhesion. However, the latter caused significant dentine discolouration (ΔE* = 50.3). The chlorhexidine coating showed no antibacterial effect. Thus, silver nanoparticles may be a viable alternative to both chlorhexidine and silver nitrate, protecting from dental plaque and secondary caries when applied as a dentine coating, while they may provide the platform for creating anti-biofilm surfaces in medical devices and other biomedical applications.
- Nanotoxicology.Nanotoxicology.2014 Nov;8:745-54. doi: 10.3109/17435390.2013.825343. Epub 2013 Aug 7.
- Abstract The survival of pathogenic bacteria in the oral cavity depends on their successful adhesion to dental surfaces and their ability to develop into biofilms, known as dental plaque. Bacteria from the dental plaque are responsible for the development of dental caries, gingivitis, periodontitis,
- PMID 23875717
- A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces.
- Hoesli CA, Garnier A, Juneau PM, Chevallier P, Duchesne C, Laroche G.Author information Centre de Recherche sur les Matériaux Avancés, Département de génie des mines, de la métallurgie et des matériaux, Université Laval, Québec G1V 0A6, Canada; Centre de recherche du CHU de Québec, Hôpital Saint-François d'Assise, Québec G1L 3L5, Canada; PROTEO Research Center and Département de génie chimique, Université Laval, Québec G1V 0A6, Canada. Electronic address: corinne.hoesli@gmail.com.AbstractThe long-term patency rates of vascular grafts and stents are limited by the lack of surface endothelialisation of the implanted materials. We have previously reported that GRGDS and WQPPRARI peptide micropatterns increase the endothelialisation of prosthetic materials in vitro. To investigate the mechanisms by which the peptide micropatterns affect endothelial cell adhesion and proliferation, a TAMRA fluorophore-tagged RGD peptide was designed. Live cell imaging revealed that the micropatterned surfaces led to directional cell spreading dependent on the location of the RGD-TAMRA spots. Focal adhesions formed within 3 h on the micropatterned surfaces near RGD-TAMRA spot edges, as expected for cell regions experiencing high tension. Similar levels of focal adhesion kinase phosphorylation were observed after 3 h on the micropatterned surfaces and on surfaces treated with RGD-TAMRA alone, suggesting that partial RGD surface coverage is sufficient to elicit integrin signaling. Lastly, endothelial cell expansion was achieved in serum-free conditions on gelatin-coated, RGD-TAMRA treated or micropatterned surfaces. These results show that these peptide micropatterns mainly impacted cell adhesion kinetics rather than cell proliferation. This insight will be useful for the optimization of micropatterning strategies to improve vascular biomaterials.
- Biomaterials.Biomaterials.2014 Jan;35(3):879-90. doi: 10.1016/j.biomaterials.2013.09.076. Epub 2013 Oct 31.
- The long-term patency rates of vascular grafts and stents are limited by the lack of surface endothelialisation of the implanted materials. We have previously reported that GRGDS and WQPPRARI peptide micropatterns increase the endothelialisation of prosthetic materials in vitro. To investigate the
- PMID 24183170
- Nanotopographical control for maintaining undifferentiated human embryonic stem cell colonies in feeder free conditions.
- Bae D, Moon SH, Park BG, Park SJ, Jung T, Kim JS, Lee KB, Chung HM.Author information CHA Bio & Diostech Co., Ltd., Seoul 135-081, Republic of Korea.AbstractRecently emerging evidence has indicated surface nanotopography as an important physical parameter in the stem cell niche for regulating cell fate and behaviors for various types of stem cells. In this study, a substrate featuring arrays of increasing nanopillar diameter was devised to investigate the effects of varying surface nanotopography on the maintenance of undifferentiated human embryonic stem cells (hESC) colonies in the absence of feeder cells. Single hESCs cultured across gradient nanopattern (G-Np) substrate were generally organized into compact colonies, and expressed higher levels of undifferentiated markers compared to those cultured on the unstructured control substrate. In particular, hESC demonstrates a propensity to organize into more compact colonies expressing higher levels of undifferentiated markers towards a smaller nanopillar diameter range (D = 120-170 nm). Cell-nanotopography interactions modulated the formation of focal adhesions and cytoskeleton reorganization to restrict colony spreading, which reinforced E-cadherin mediated cell-cell adhesions in hESC colonies. Maintaining compact hESC colony integrity revealed to be indispensable for hESC undifferentiated state as the loss of cell-cell adhesions within spreading hESC on the control substrate exhibited morphological and gene expression signatures of epithelial-to-mesenchymal transition-like processes. Findings in this study demonstrated a feasible approach to screen the optimal nanotopographical cues for maintaining undifferentiated hESC colonies in feeder free conditions, which provides a platform for further investigations into developing hESC feeder free culture systems for the purpose of regenerative medicine.
- Biomaterials.Biomaterials.2014 Jan;35(3):916-28. doi: 10.1016/j.biomaterials.2013.10.031. Epub 2013 Oct 29.
- Recently emerging evidence has indicated surface nanotopography as an important physical parameter in the stem cell niche for regulating cell fate and behaviors for various types of stem cells. In this study, a substrate featuring arrays of increasing nanopillar diameter was devised to investigate t
- PMID 24183167
Japanese Journal
- デンタルプラーク
- 膜 42(2), 46-53, 2017
- NAID 130005492512
- SiO<sub>2</sub>-nanocomposite film coating of CAD/CAM composite resin blocks improves surface hardness and reduces susceptibility to bacterial adhesion
- Dental Materials Journal 36(1), 88-94, 2017
- NAID 130005308588
- 純チタン表面に成膜したDLCに対する掻爬
- 砥粒加工学会誌 60(1), 40-41, 2016
- NAID 130005284466
Related Links
- Definition of ADHESION PLAQUE: Subcellular macromolecular assemblies across which mechanical force and regulatory signals are transmitted. They can contain over 100 different proteins. ... What is ADHESION PLAQUE? ...
- focal adhesion plaque [ fō·kəl əd′hē·zhən ‚plak] (cell and molecular biology) Points of attachment that form when cells attach to a substrate.
Related Pictures
★リンクテーブル★
| リンク元 | 「接着点」「focal adhesion」「接着板」 |
| 関連記事 | 「adhesion」「plaque」 |
「接着点」
「focal adhesion」
「接着板」
- 英
- adhesion plaque
- 関
- 付着板、接着点
「adhesion」
- n
「plaque」
- n.