WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
fibrosis of the bone marrow

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の

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1. 急性骨髄性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute myeloid leukemia
2. 原発性骨髄線維症の臨床症状および診断 clinical manifestations and diagnosis of primary myelofibrosis
3. ダウン症の臨床的特徴および診断 clinical features and diagnosis of down syndrome
4. 急性骨髄性白血病の予後 prognosis of acute myeloid leukemia
5. 若年成人における急性骨髄性白血病に対する導入療法 induction therapy for acute myeloid leukemia in younger adults

Elidrissy AT1.
Calcified tissue international.Calcif Tissue Int.2016 Sep;99(3):227-36. doi: 10.1007/s00223-016-0146-2. Epub 2016 May 31.
Congenital rickets is the term given to fetus born with clinical features of rickets, but those born with biochemical evidence of rickets without obvious clinical features still can be considered occult congenital rickets. Some of the affected babies with this disease have the intrauterine rachitic
PMID 27245342

Clinical use of ruxolitinib in an academic medical center in unselected patients with myeloproliferative neoplasms not on clinical study.

Naqvi K1, Daver N1, Pemmaraju N1, Bose P1, Garcia-Manero G1, Cortes J1, Kantarjian HM1, Verstovsek S1.
Leukemia & lymphoma.Leuk Lymphoma.2016 Aug 5:1-6. [Epub ahead of print]
Ruxolitinib is the only approved therapy for myelofibrosis (MF). However, its use in patients with myeloproliferative neoplasms (MPN) not participating in clinical studies has been poorly described. We reviewed the medical records of 45 patients (35 MF, 10 others) treated with ruxolitinib at our cen
PMID 27494751

The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells.

Giordani G1,2, Barraco M1,3, Giangrande A4, Martinelli G5, Guadagnuolo V5, Simonetti G5, Perini G1,6, Bernardoni R1,6.
Oncotarget.Oncotarget.2016 Jul 28. doi: 10.18632/oncotarget.10879. [Epub ahead of print]
The efficient treatment of hematological malignancies as Acute Myeloid Leukemia, myelofibrosis and Chronic Myeloid Leukemia, requires the elimination of cancer-initiating cells and the prevention of disease relapse through targeting pathways that stimulate generation and maintenance of these cells.
PMID 27486815