activating transcription factor 1

活性化転写因子1、転写因子ATF1

関

ATF1

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. (genetics) the organic process whereby the DNA sequence in a gene is copied into mRNA; the process whereby a base sequence of messenger RNA is synthesized on a template of complementary DNA
12. a sound or television recording (e.g., from a broadcast to a tape recording)
13. something written, especially copied from one medium to another, as a typewritten version of dictation (同)written text
14. causing motion or action or change (同)actuating

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 〈U〉(…を)書き写す(書き直す)こと,(…の)転写,謄写《+of+名》 / 〈C〉写し(書き直し)[たもの] / 〈U〉〈C〉編曲[されたもの] / 〈U〉〈C〉(ラジオ・テレビの)録音(録画)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/14 03:35:28」(JST)

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[Wiki en表示]

ATF1
Identifiers
Aliases	ATF1, EWS-FUS/ATF-1, TREB36, activating transcription factor 1
External IDs	MGI: 3037720 HomoloGene: 3790 GeneCards: ATF1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • protein complex binding • protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • ATF1-ATF4 transcription factor complex • transcription factor complex • nucleoplasm • nucleus Biological process • regulation of transcription, DNA-templated • response to organic cyclic compound • cellular protein complex assembly • transcription, DNA-templated • positive regulation of DNA replication • positive regulation of neuron projection development • response to cobalt ion • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	466	100040260
Ensembl	ENSG00000123268	n/a
UniProt	P18846	n/a
RefSeq (mRNA)	NM_005171	n/a
RefSeq (protein)	NP_005162	n/a
Location (UCSC)	Chr 12: 50.76 – 50.82 Mb	n/a
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

Clinical significance

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

See also

• Activating transcription factor

Interactions

ATF1 has been shown to interact with:

• BRCA1,
• CSNK2A2,
• CSNK2A1, and
• EWS.

Further reading

• Fujimura Y, Ohno T, Siddique H, Lee L, Rao VN, Reddy ES (January 1996). "The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator". Oncogene. 12 (1): 159–67. PMID 8552387. 
• Fujimura Y, Siddique H, Lee L, Rao VN, Reddy ES (October 2001). "EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function". Oncogene. 20 (46): 6653–9. PMID 11709699. doi:10.1038/sj.onc.1204684. 
• Rehfuss RP, Walton KM, Loriaux MM, Goodman RH (1991). "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.". J. Biol. Chem. 266 (28): 18431–4. PMID 1655749. 
• Yoshimura T, Fujisawa J, Yoshida M (1990). "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.". EMBO J. 9 (8): 2537–42. PMC 552284 . PMID 2196176. 
• Hai TW, Liu F, Coukos WJ, Green MR (1990). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.". Genes Dev. 3 (12B): 2083–90. PMID 2516827. doi:10.1101/gad.3.12b.2083. 
• Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer.". J. Biol. Chem. 270 (17): 10304–13. PMID 7730336. doi:10.1074/jbc.270.17.10304. 
• Liu F, Thompson MA, Wagner S, et al. (1993). "Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.". J. Biol. Chem. 268 (9): 6714–20. PMID 8384217. 
• Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene. 11 (11): 2255–65. PMID 8570175. 
• Sun P, Lou L, Maurer RA (1996). "Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV.". J. Biol. Chem. 271 (6): 3066–73. PMID 8621702. doi:10.1074/jbc.271.6.3066. 
• Shimomura A, Ogawa Y, Kitani T, et al. (1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein.". J. Biol. Chem. 271 (30): 17957–60. PMID 8663317. doi:10.1074/jbc.271.30.17957. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791. 
• Kobayashi M, Shimomura A, Hagiwara M, Kawakami K (1997). "Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter.". Nucleic Acids Res. 25 (4): 877–82. PMC 146500 . PMID 9016641. doi:10.1093/nar/25.4.877. 
• Soubt MK, Marksitzer R, Menoud PA, Nagamine Y (1998). "Role of tissue-specific transcription factor LFB3 in a cyclic AMP-responsive enhancer of the urokinase-type plasminogen activator gene in LLC-PK1 cells.". Mol. Cell. Biol. 18 (8): 4698–706. PMC 109056 . PMID 9671480. 
• Yamaguchi Y, Wada T, Suzuki F, et al. (1998). "Casein kinase II interacts with the bZIP domains of several transcription factors.". Nucleic Acids Res. 26 (16): 3854–61. PMC 147779 . PMID 9685505. doi:10.1093/nar/26.16.3854. 
• Pellín A, Monteagudo C, López-Ginés C, et al. (1999). "New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts).". Genes Chromosomes Cancer. 23 (4): 358–60. PMID 9824209. doi:10.1002/(SICI)1098-2264(199812)23:4<358::AID-GCC11>3.0.CO;2-3. 
• Kabe Y, Goto M, Shima D, et al. (1999). "The role of human MBF1 as a transcriptional coactivator.". J. Biol. Chem. 274 (48): 34196–202. PMID 10567391. doi:10.1074/jbc.274.48.34196. 
• Sawada J, Simizu N, Suzuki F, et al. (2000). "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family.". J. Biol. Chem. 274 (50): 35475–82. PMID 10585419. doi:10.1074/jbc.274.50.35475. 
• Houvras Y, Benezra M, Zhang H, et al. (2000). "BRCA1 physically and functionally interacts with ATF1.". J. Biol. Chem. 275 (46): 36230–7. PMID 10945975. doi:10.1074/jbc.M002539200. 
• Knöfler M, Saleh L, Bauer S, et al. (2000). "Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblasts.". Endocrinology. 141 (10): 3737–48. PMID 11014230. doi:10.1210/en.141.10.3737. 
• Arthur JS, Cohen P (2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.". FEBS Lett. 482 (1-2): 44–8. PMID 11018520. doi:10.1016/S0014-5793(00)02031-7. 
• Andreucci JJ, Grant D, Cox DM, et al. (2002). "Composition and function of AP-1 transcription complexes during muscle cell differentiation.". J. Biol. Chem. 277 (19): 16426–32. PMID 11877423. doi:10.1074/jbc.M110891200. 

External links

• ATF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human ATF1 genome location and ATF1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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English Journal

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• We report a case of clear cell sarcoma (CCS) in the left buttock in which serum neuron-specific enolase (NSE) was useful as a biomarker of CCS progression. A 40-year-old man had a subcutaneous tumor, 1.7 cm in diameter, in the left buttock. Histopathology revealed that the tumor consisted of nests
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Japanese Journal

• Silencing of IFN-stimulated gene transcription is regulated by histone H1 and its chaperone TAF-I

• Kadota Shinichi,Nagata Kyosuke
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• … Chromatin structure and its alteration play critical roles in the regulation of transcription. … Here we investigated the role of template activating factor-I (TAF-I, also known as SET) in ISG transcription. … Knockdown (KD) of TAF-I increased ISG transcript and simultaneously reduced the histone H1 level on the ISG promoters during the early stages of transcription after IFN stimulation from the unstimulated state. …
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• ビタミン 88(1), 18-24, 2014-01-25
• … VK functions as a co-factor of VK-dependent γ-glutamyl carboxylase (GGCX) in mediating post-translational modifications. … On the other hand, VK_2 also regulates the transcription of bone-related genes in osteoblasts through activating steroid X receptor (SXR)/pregnane X receptor (PXR), as well as enhancing the phosphorylation of protein kinase A (PKA). …
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• Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 17(3), 423-430, 2014
• NAID 40020215924

Related Links

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★リンクテーブル★

リンク元	「転写因子ATF1」「活性化転写因子1」「ATF1」
関連記事	「fact」「factor」「transcription factor」

「転写因子ATF1」

　　[★]

英

activating transcription factor 1、ATF1

関

活性化転写因子1

「活性化転写因子1」

　　[★]

英

activating transcription factor 1

関

転写因子ATF1

「ATF1」

　　[★]

• 転写因子ATF1

関

activating transcription factor 1

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「transcription factor」

　　[★]

• 転写制御因子、転写因子

関

TF、transcriptional regulator、transcriptional regulatory element