dactinomycin

アクチノマイシンD


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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/14 22:34:16」(JST)

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English Journal

  • The use of isolated limb infusion in limb threatening extremity sarcomas.
  • Vohra NA, Turaga KK, Gonzalez RJ, Conley A, Reed D, Bui MM, Cheong D, Letson DG, Zager JS.SourceDepartment of Sarcoma Oncology, Moffitt Cancer Center , Tampa , Florida.
  • International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.Int J Hyperthermia.2012 Dec 3. [Epub ahead of print]
  • This paper reports a single-institution experience with the use of isolated limb infusion for limb salvage in locally advanced, unresectable, recurrent limb threatening soft tissue sarcomas. Background: Locally advanced, limb threatening soft tissue sarcomas (STS) pose a significant treatment chal
  • PMID 23205633
  • What is New in Rhabdomyosarcoma Management in Children?
  • Gosiengfiao Y, Reichek J, Walterhouse D.SourceAnn and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Division of Hematology/Oncology/Stem Cell Transplant, Chicago, IL, USA.
  • Paediatric drugs.Paediatr Drugs.2012 Dec 1;14(6):389-400. doi: 10.2165/11599440-000000000-00000.
  • Optimal management of rhabdomyosarcoma requires establishing the correct pathologic diagnosis, histologic sub-type, primary site, extent of disease (Stage), and extent of resection (Group). Based on these features, cooperative groups in North America and Europe have defined risk-adapted treatments t
  • PMID 23050743

Japanese Journal

  • A Clinical Study on Parotid Tumors in Children and Adolescents
  • Hori Ryusuke,Shoji Kazuhiko,Hamaguchi Kiyomi,Okanoue Yusuke,Fujimura Shintaro,Wakizaka Hitomi
  • 耳鼻咽喉科臨床 補冊 137(0), 58-59, 2013
  • … According to the Intergroup Rhabdomyosarcoma Study-IV, which was mostly used for the treatment of rhabdomyosarcoma, chemotherapy using vincristine, dactinomycin, and cyclophosphamide was performed as a postoperative treatment. …
  • NAID 130004558717
  • 臨床 小児・若年者耳下腺腫瘍の検討
  • 堀 龍介,庄司 和彦,濱口 清海 [他],岡上 雄介,藤村 真太郎,脇坂 仁美
  • 耳鼻咽喉科臨床 106(1), 23-28, 2013
  • … According to the Intergroup Rhabdomyosarcoma Study-IV, which was mostly used for the treatment of rhabdomyosarcoma, chemotherapy using vincristine, dactinomycin, and cyclophosphamide was performed as a postoperative treatment. …
  • NAID 130003373993
  • 副腎癌との鑑別が困難だった後腹膜Ewing肉腫の1例
  • 佐藤 真彦,宮里 実,山田 成幸 [他]
  • 泌尿器科紀要 57(6), 303-307, 2011-06
  • … Considering it a high risk, we started adjuvant VAIA(vincristine, dactinomycin, ifosfamide, and doxorubicin) chemotherapy soon after the operation. …
  • NAID 40018861642

Related Links

Actinomycin D (also known generically as Actinomycin or Dactinomycin), is the most significant member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces. As one of the older ...
11 Feb 2010 ... Dactinomycin is used to treat Wilms and Ewings tumors, testicular cancer, sarcomas (cancers that grow from cartilage, fat, muscle, or bone), and other types of cancer.


Related Pictures

Plik:Dactinomycin structure.png Dactinomycin 50-76-0, Information for dactinomycin Intravenous - patient Dactinomycin has the following structural Generic Cosmegen ? Dactinomycin 500 mcg Dactinomycin - drug review: dosage, side



★リンクテーブル★
リンク元絨毛癌」「アクチノマイシンD」「抗悪性腫瘍薬」「Cosmegen

絨毛癌」

  [★]

chorio
choriocarcinoma
絨毛上皮腫 chorioepithelioma
悪性合胞体腫、絨毛疾患

疫学

  • 日本、東南アジア、中東、ラテンアメリカに多い
  • 人口10万人にたいして年間0.05人
  • 正常妊娠からは5-10万例に1例、全胞状奇胎の1-2%に発症、部分胞状奇胎では稀とされる(G9M.184)

病理

NGY.242
  • 組織構造:絨毛構造無し。破壊的増殖。出血、壊死。
  • 細胞形態:細胞性、合胞体、中間型栄養膜細胞に類似した細胞。破壊的な増殖像。細胞異型あり

failpicload@./t_image/097D023.jpg

転移

  • 血行性転移

治療

  • 化学療法:(参考1)
  • EMA/CO regimen
  • EMA regimen
  • MAC regimen
  • 手術療法:子宮、肺の病変に関しては適応となることがある。
  • 放射線療法:脳、肝臓に対して行われる。

参考

  • 1. [charged]Malignant gestational trophoblastic disease: Staging and treatment - uptodate

[1]

国試

アクチノマイシンD」

  [★]

actinomycin D actinomycin-D ACT-D
アクチノマイシン actinomycinダクチノマイシン dactinomycin DACTCosmegen
コスメゲン Cosmegen


  • first aid step1 2006 p.307,309,326

分類

  • 抗生物質

構造

作用機序

  • intercalates in DNA

適応

  • Wilms' tumor, Ewing's sarcoma, rhabdomyosarcoma(first aid step1 2006 p.309) ← 子供の腫瘍

副作用

  • myelosuppression

抗悪性腫瘍薬」

  [★]

antineoplastic drug, antitumor agent, antitumor drug
抗腫瘍薬 antineoplastics、抗癌薬 anticancer drug AZT
制癌薬


細胞周期依存性

first aid step1 2006 p.307,308

細胞周期依存的

細胞周期非依存的

Cosmegen」

  [★]

コスメゲン

actinomycinactinomycin Ddactinomycin