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1. 糸球体足細胞のバイオロジーbiology of glomerular podocytes [show details]
…distinct actin cytoskeletal networks present in the foot processes : Dense actin bundles are present above the level of the slit diaphragm and extend parallel to the longitudinal axis. A cortical actin network …
2. 赤血球細胞膜：構造、機構、動態red blood cell membrane structure organization and dynamics [show details]
…binding sites for multiple short actin filaments. A junctional complex is formed between beta-spectrin, actin, and protein 4.1 . Adducin also stabilizes the spectrin/actin/protein 4.1 junctional complex …
3. T細胞受容体シグナル伝達t cell receptor signaling [show details]
…protein (SLP-76). Further signaling proteins are then recruited, resulting in calcium mobilization, actin cytoskeleton reorganization, and activation of Ras guanosine triphosphate hydrolases (GTPases). Downstream …
4. 拡張型心筋症の遺伝学genetics of dilated cardiomyopathy [show details]
…(VCL) and its isoform, metavinculin, has been identified on chromosome 10q22.1-q23 . Vinculin and metavinculin are protein components of intercalated discs, structures that anchor thin actin filaments and …
5. 心筋における興奮収縮連関excitation contraction coupling in myocardium [show details]
…myofibril. The thin filament is composed of two strands of F-actin wound around each other. Each strand of F-actin is composed of globular G-actin monomers, polymerized in a linear pattern. The thick filament …

English Journal

Role of membrane shape in regulating the phosphatidylinositol cycle at contact sites.

Bozelli JC, Epand RM.
Chemistry and physics of lipids. 2019 Jul;221()24-29.
The extensive number of metabolic processes regulated by phosphatidylinositol (PI) phospholipids highlights their physiological importance. The major metabolic pathway for their biosynthesis in cells is the PI-cycle. Contrary to most metabolic cycles, reactions of the PI-cycle occur in two different
PMID 30851248

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.

Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, Zhang J, Deng X, Yao Y, Tang Z, Yin B, Wang J, Jiang K, Li Z, Choi Y, Gong F, Cheng X, O'Shea JJ, Chae JJ, Laurence A, Yang XP.
Autophagy. 2019 Jun;15(6)960-975.
Macroautophagy/autophagy is a conserved ubiquitous pathway that performs diverse roles in health and disease. Although many key, widely expressed proteins that regulate autophagosome formation followed by lysosomal fusion have been identified, the possibilities of cell-specific elements that contrib
PMID 30681394

Systemic disruption of the homeostasis of transfer RNA isopentenyltransferase causes growth and development abnormalities in Bombyx mori.

Chen Y, Bai B, Yan H, Wen F, Qin D, Jander G, Xia Q, Wang G.
Insect molecular biology. 2019 Jun;28(3)380-391.
Isopentenylation at A37 (i A37) of some transfer RNAs (tRNAs) plays a vital role in regulating the efficiency and fidelity of protein synthesis. However, whether insects, which are well known for their highly efficient protein synthesis machinery, employ this regulatory mechanism remains uninvestiga
PMID 30548717

Japanese Journal

Different contributions of nonmuscle myosin IIA and IIB to the organization of stress fiber subtypes in fibroblasts

Kuragano Masahiro,Uyeda Taro Q. P.,Kamijo Keiju,Murakami Yota,Takahashi Masayuki
Molecular biology of the cell 29(8), 911-922, 2018-04-15
… Knockdown (KD) of NMIIA (a major isoform) resulted in loss of TAs from the lamella and caused the lamella to lose its flattened shape. … Moreover, we raised the possibility that actin filaments in vSFs are in a stretched conformation. …
NAID 120006517689

アクチンアイソフォーム間の機能の違いを決定する要因は?

黒坂哲
Memoirs of Institute of Advanced Technology, Kinki University = 近畿大学先端技術総合研究所紀要 (23), 23-29, 2018-03
… Actin is the major component of cytoskeleton, and essential for various biological functions in cells and organisms.Mammals have 6 isoforms of actins which are encoded by different genes, and their amino acid sequences are highly conserved.Knockout mice for each actin isoform have different phenotypes indicating that every actin isoform has distinct functions. …
NAID 120006469828

Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells

Yamada Hiroshi,Takeda Tetsuya,Michiue Hiroyuki,Abe Tadashi,Takei Kohji
International Journal of Oncology 49(3), 877-886, 2016-06-30
… The endocytic protein dynamin participates in the formation of actin-based membrane protrusions such as podosomes, pseudopodia, and invadopodia, which facilitate cancer cell migration, invasion, and metastasis. … However, the role of dynamin in the formation of actin-based membrane protrusions at the leading edge of cancer cells is unclear. …
NAID 120006352349