V1bバソプレシン受容体、V1bバソプレシンレセプター

関: V1 receptor、V1a vasopressin receptor、V2 receptor、vasopressin receptor

WordNet

hormone secreted by the posterior pituitary gland (trade name Pitressin) and also by nerve endings in the hypothalamus; affects blood pressure by stimulating capillary muscles and reduces urine flow by affecting reabsorption of water by kidney tubules (同)antidiuretic_hormone, ADH, Pitressin
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the 22nd letter of the Roman alphabet (同)v

PrepTutorEJDIC

=sense organ / 受信装置
V1号[ロケット爆弾](第二次世界大戦中,ドイツ軍が英国攻撃用に使った)
vanadium の化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/14 22:55:27」(JST)

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Vasopressin V1b receptor (V1bR) also known as vasopressin 3 receptor (VPR3) or antidiuretic hormone receptor 1b is a protein that in humans is encoded by the AVPR1B (arginine vasopressin receptor 1B) gene.

V1bR acts as receptor for arginine vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.It is a major contributor to homeostasis and the control of water, glucose, and salts in the blood. Arginine vasopressin has four receptors, each of which are located in different tissues and have specific functions. AVPR1b is a g-protein coupled pituitary receptor that has only recently been characterized because of its rarity.^[1]

It has been found that the 420-amino-acid sequence of the AVPR1B receptor shared the most overall similarities with the AVP1A, AVP2 and oxytocin receptors.^[2] AVPR1B maps to chromosome region 1q32 and is a member of the vasopressin/oxytocin family subfamily.^[3]

Tissue distribution

AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release.^[4] Subsequent studies have shown that it is also present in the brain.^[5]^[6]

Clinical significance

Behavioral

Inactivation of the Avpr1b gene in mice (knockout) produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice.^[7] Interestingly, defensive behaviour and predatory behaviours appear normal in these knockout mice,^[8] but there is evidence that social motivation or awareness is reduced.^[9] The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters^[10] and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats.^[11] A single nucleotide polymorphism (SNP) has been associated with susceptibility to depression in man.^[2]

Metabolic

Various stress-induced elevations of ACTH are blunted in the Avpr1b knockout mouse.^[12]

Oncology

AVPR1B is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids^[13] responsible for the ectopic ACTH syndrome.^[14]

Ligands

Nelivaptan (SSR149415)^[15] and D-[Leu⁴-Lys⁸]-vasopressin^[16] are a specific antagonist and agonist for the vasopressin 1b receptor, respectively.

Function

AVPR1B is found in different parts of the body and thus has several influences and regulatory actions. Arginine vasopressin influences several symptoms related to affective disorders including significant memory processes, pain sensitivity, synchronization of biological rhythms and the timing and quality of REM sleep.^[2] Studies have shown that AVPR1B deficiencies produce behavioral changes that can be reversed when the peptide is replaced.^[2] These effects are expressed through contact with specific plasma membrane receptors.^[2] AVPR1B is responsible for fueling the effects of vasopressin on ACTH release.^[3] This interaction takes place as Arginine Vasopressin works with corticotropin releasing hormone to stimulate the pituitary gland to secrete ACTH.^[2] AVPR1b is then responsible for mediating the stimulatory effect of vasopressin on ACTH release. Several G proteins are also involved in the signal transduction pathways linked with AVPR1B.^[1] These relationships depend on the level of receptor expression and concentration of vasopressin.^[1] For example, AVPR1B causes secretion of ACTH from the anterior pituitary cells in a dose-dependent relationship by activating protein kinase C via the Gq/11 protein.^[1]

Application

There have been several experiments which have studied these interactions further and revealed AVPR1B’s role in psychological disorders and regulatory functions. Halotypes of AVPR1B are associated with increased protective effects to recurrent major depression.^[2] AVPR1B has also been associated with higher cortisol responses to psychosocial stress in children with psychiatric disorders compared with carriers of glucocorticoid receptor gene.^[17] AVPR1b has also shown involvement in regulation of brain water content and cerebral edema.^[18] This was revealed as increased levels of AVPR1B mRNA on the choroid plexus were discovered as a result of increased plasma osmolality.^[18] The increase after a reduction of brain water content from salt water loading indicated AVPR1B’s role in the neuroendocrine feedback loop in maintaining normal central nervous system fluid balance.^[18]

References

^ ^a ^b ^c ^d Holmes CL, Landry DW, Granton JT (December 2003). "Science review: Vasopressin and the cardiovascular system part 1--receptor physiology". Crit Care 7 (6): 427–34. doi:10.1186/cc2337. PMC 374366. PMID 14624682.
^ ^a ^b ^c ^d ^e ^f ^g van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, Forsgren T, Sluijs S, Bel-Kacem S, Adolfsson R, Mendlewicz J, Van Duijn C, Deboutte D, Van Broeckhoven C, Claes S (March 2004). "A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression". Mol. Psychiatry 9 (3): 287–92. doi:10.1038/sj.mp.4001420. PMID 15094789.
^ ^a ^b "anti-Arginine Vasopressin Receptor 1B (AVPR1B) antibody (ABIN122463)". antibodies-online.
^ Antoni FA, Holmes MC, Makara GB, Kárteszi M, László FA (1984). "Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor". Peptides 5 (3): 519–22. doi:10.1016/0196-9781(84)90080-9. PMID 6089144.
^ Hernando F, Schoots O, Lolait SJ, Burbach JP (2001). "Immunohistochemical localization of the vasopressin V_1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin". Endocrinology 142 (4): 1659–68. doi:10.1210/en.142.4.1659. PMID 11250948.
^ Young WS, Li J, Wersinger SR, Palkovits M (2006). "The Vasopressin 1b Receptor is Prominent in the Hippocampal Area CA2 Where It Is Unaffected by Restraint Stress or Adrenalectomy". Neuroscience 143 (4): 1031–9. doi:10.1016/j.neuroscience.2006.08.040. PMC 1748954. PMID 17027167.
^ Wersinger SR, Ginns EI, O'Carroll AM, Lolait SJ, Young WS (2002). "AVPR1B knockout reduces aggressive behavior in male mice". Mol. Psychiatry 7 (9): 975–84. doi:10.1038/sj.mp.4001195. PMID 12399951.
^ Wersinger SR, Caldwell HK, Christiansen M, Young WS (2007). "Disruption of the Vasopressin 1b Receptor Gene Impairs the Attack Component of Aggressive Behavior in Mice". Genes, Brain and Behavior 6 (7): 653–60. doi:10.1111/j.1601-183X.2006.00294.x. PMC 2486432. PMID 17284170.
^ Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS (2004). "Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task". Hormones and Behavior 46 (5): 638–45. doi:10.1016/j.yhbeh.2004.07.004. PMID 15555506.
^ Blanchard RJ, Griebel G, Farrokhi C, Markham C, Yang M, Blanchard DC (2005). "AVP V_1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters". Pharmacol. Biochem. Behav. 80 (1): 189–94. doi:10.1016/j.pbb.2004.10.024. PMID 15652395.
^ Serradeil-Le Gal C, Wagnon J, Tonnerre B, Roux R, Garcia G, Griebel G, Aulombard A (2005). "An overview of SSR149415, a selective nonpeptide vasopressin V_1b receptor antagonist for the treatment of stress-related disorders". CNS Drug Reviews 11 (1): 53–68. doi:10.1111/j.1527-3458.2005.tb00035.x. PMID 15867952.
^ Lolait SJ, Stewart LQ, Jessop DS, Young WS, O'Carroll AM (2007). "The Hypothalamic-Pituitary-Adrenal Axis Response to Stress in Mice Lacking Functional Vasopressin V1b Receptors". Endocrinology 148 (2): 849–56. doi:10.1210/en.2006-1309. PMC 2040022. PMID 17122081.
^ Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolio B, Grossman AB, Reincke M (1997). "Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro". Clin. Endocrinol. (Oxf) 47 (5): 623–7. doi:10.1046/j.1365-2265.1997.3091129.x. PMID 9425403.
^ de Keyzer Y, Lenne F, Auzan C, Jégou S, René P, Vaudry H, Kuhn JM, Luton JP, Clauser E, Bertagna X (1996). "The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome". J. Clin. Invest. 97 (5): 1311–8. doi:10.1172/JCI118547. PMC 507185. PMID 8636444.
^ Serradeil-Le Gal C, Wagnon J, Simiand J, Griebel G, Lacour C, Guillon G, Barberis C, Brossard G, Soubrié P, Nisato D, Pascal M, Pruss R, Scatton B, Maffrand JP, Le Fur G (2002). "Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V_1b receptor antagonist". J. Pharmacol. Exp. Ther. 300 (3): 1122–30. doi:10.1124/jpet.300.3.1122. PMID 11861823.
^ Pena A, Murat B, Trueba M, Ventura MA, Bertrand G, Cheng LL, Stoev S, Szeto HH, Wo N, Brossard G, Serradeil-Le Gal C, Manning M, Guillon G (2007). "Pharmacological and physiological characterization of d[Leu⁴, Lys⁸]vasopressin, the first V_1b-selective agonist for rat vasopressin/oxytocin receptors". Endocrinology 148 (9): 4136–46. doi:10.1210/en.2006-1633. PMID 17495006.
^ van West D, Del-Favero J, Deboutte D, Van Broeckhoven C, Claes S (August 2010). "Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population". Psychiatry Res 179 (1): 64–8. doi:10.1016/j.psychres.2009.04.002. PMID 20472303.
^ ^a ^b ^c Zemo DA, McCabe JT (2001). "Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus". Neuropeptides 35 (3-4): 181–8. doi:10.1054/npep.2001.0864. PMID 11884209.

External links

Receptors, Vasopressin at the US National Library of Medicine Medical Subject Headings (MeSH)
"Symbol Report: AVPR1B". Human Geneome Organization Gene Nomenclature Committee.
"Vasopressin and Oxytocin Receptors: V_1B". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

UpToDate Contents

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1. 成人における低ナトリウム血症の治療の概要overview of the treatment of hyponatremia in adults [show details]
…of an ADH receptor antagonist . There are multiple receptors for the ADH vasopressin: the V1a, V1b, and V2 receptors. The V2 receptors primarily mediate the antidiuretic response, while V1a and V1b receptors …
2. デスモプレシン（DDAVP）を用いる刺激試験desmopressin ddavp stimulation test [show details]
…promotes the secretion of corticotropin (ACTH) via activation of arginine-vasopressin receptor 1B (AVPR1B, previously named V1B or V3 receptor) present in corticotropes . Cortisol inhibits the secretion…
3. 肝硬変患者における低ナトリウム血症hyponatremia in patients with cirrhosis [show details]
…interventions . Vasopressin receptor antagonists can raise the serum sodium in patients with hyponatremia due to cirrhosis. There are multiple receptors for vasopressin (ADH): the V1a, V1b, and V2 receptors …
4. 心不全患者における低ナトリウム血症hyponatremia in patients with heart failure [show details]
… V1b, and V2 receptors. The V2 receptors primarily mediate the antidiuretic response, while V1a and V1b receptors principally mediate… The vasopressin receptor antagonists produce a selective water diuresis without affecting sodium and potassium excretion .…
5. 低ナトリウム血症の治療：抗利尿ホルモン不適合分泌（SIADH）症候群およびreset osmostat症候群treatment of hyponatremia syndrome of inappropriate antidiuretic hormone secretion siadh and reset osmostat [show details]
… V1b, and V2 receptors. The V2 receptors primarily mediate the antidiuretic response, while V1a and V1b receptors primarily cause vasoconstriction… hyponatremia in the SIADH, with fluid restriction, salt administration, urea administration, and vasopressin receptor antagonists being most important . When treating such patients, attention must be paid to …

English Journal

Targeting hyponatremia and hemodynamics in acute decompensated heart failure: is there a role for vasopressin antagonists?

Valania G, Singh M, Slawsky MT.SourceTufts University School of Medicine, Baystate Medical Center, S-4665, Cardiology, 759 Chestnut Street, Springfield, MA, 01199, USA.
Current heart failure reports.Curr Heart Fail Rep.2011 Sep;8(3):198-205.
Current treatment of acute decompensated heart failure (ADHF) has not reduced the significant morbidity or mortality associated with this disease, and has promoted drug development aimed at neurohormonal targets. Hypervolemic hyponatremia, which is linked to the nonosmotic release of arginine vasopr
PMID 21046492

Facilitation of glutamate and GABA release by P2X receptor activation in supraoptic neurons from freshly isolated rat brain slices.

Vavra V, Bhattacharya A, Zemkova H.SourceDepartment of Cellular and Molecular Neuroendocrinology, Institute of Physiology of the Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic.
Neuroscience.Neuroscience.2011 Aug 11;188:1-12. Epub 2011 May 7.
The supraoptic nuclei (SON), the hypothalamic release site of vasopressin and oxytocin, receive a non-glutamatergic, excitatory input from the caudal medulla that uses noradrenaline and ATP as neurotransmitters. Here, we studied the actions of extracellular ATP on SON neurons in hypothalamic slices
PMID 21575687

Japanese Journal

Vasopressin Signal Inhibition in Aged Mice Decreases Mortality under Chronic Jet Lag

iScience 5, 118-122, 2018-07-27
NAID 120006491709

A case of ectopic ACTH syndrome due to DDAVP-sensitive but V1b receptor-negative bronchial typical carcinoid with lymphatic metastasis and plasma ProGRP elevation

Endocrine Journal, 2018
NAID 130007485333

Effect of Daily Light on c-Fos Expression in the Suprachiasmatic Nucleus under Jet Lag Conditions

Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 51(2), 73-80, 2018
NAID 130006727962

「V1bバソプレシンレセプター」

Arginine vasopressin receptor 1B
Identifiers
Symbols	AVPR1B ; AVPR3
External IDs	OMIM: 600264 MGI: 1347010 HomoloGene: 22678 IUPHAR: 367 ChEMBL: 1921 GeneCards: AVPR1B Gene
Gene ontology
Molecular function	• vasopressin receptor activity; • protein kinase C binding; • peptide binding;
Cellular component	• endosome; • cytosol; • plasma membrane; • integral component of plasma membrane;
Biological process	• regulation of systemic arterial blood pressure by vasopressin; • G-protein coupled receptor signaling pathway; • activation of phospholipase C activity; • positive regulation of cytosolic calcium ion concentration; • cellular response to hormone stimulus; • positive regulation of vasoconstriction; • response to peptide;
	Sources: Amigo / QuickGO
Orthologs
	v; t; e;

　　[★]

英: V1b vasopressin receptor
関: バソプレッシン受容体、バソプレシンレセプター、V1受容体、V2レセプター、V1aバソプレシン受容体、V1bバソプレシン受容体

「V1a vasopressin receptor」

　　[★]

V1aバソプレシン受容体、V1aバソプレシンレセプター

関: V1 receptor、V1b vasopressin receptor、V2 receptor、vasopressin receptor

「V1bバソプレシン受容体」

　　[★]

英: V1b vasopressin receptor
関: V1bバソプレシンレセプター

「V1」

　　[★]

心電図：V1でRの振幅が上昇していたら：右室肥大、右脚ブロック、WPW症候群、純後壁梗塞(YN.C-25)

「V」

　　[★]

「vasopressin receptor」

　　[★] バソプレシン受容体

[pmid14624682-1] Holmes CL, Landry DW, Granton JT (December 2003). "Science review: Vasopressin and the cardiovascular system part 1--receptor physiology". Crit Care 7 (6): 427–34. doi:10.1186/cc2337. PMC 374366. PMID 14624682.

[pmid15094789-2] ^ ^a ^b ^c ^d ^e ^f ^g van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, Forsgren T, Sluijs S, Bel-Kacem S, Adolfsson R, Mendlewicz J, Van Duijn C, Deboutte D, Van Broeckhoven C, Claes S (March 2004). "A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression". Mol. Psychiatry 9 (3): 287–92. doi:10.1038/sj.mp.4001420. PMID 15094789.

[urlanti-Arginine_Vasopressin_Receptor_1B_.28AVPR1B.29_antibody_.28ABIN122463.29-3] "anti-Arginine Vasopressin Receptor 1B (AVPR1B) antibody (ABIN122463)". antibodies-online.

[pmid6089144-4] Antoni FA, Holmes MC, Makara GB, Kárteszi M, László FA (1984). "Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor". Peptides 5 (3): 519–22. doi:10.1016/0196-9781(84)90080-9. PMID 6089144.

[pmid11250948-5] Hernando F, Schoots O, Lolait SJ, Burbach JP (2001). "Immunohistochemical localization of the vasopressin V_1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin". Endocrinology 142 (4): 1659–68. doi:10.1210/en.142.4.1659. PMID 11250948.

[pmid17027167-6] Young WS, Li J, Wersinger SR, Palkovits M (2006). "The Vasopressin 1b Receptor is Prominent in the Hippocampal Area CA2 Where It Is Unaffected by Restraint Stress or Adrenalectomy". Neuroscience 143 (4): 1031–9. doi:10.1016/j.neuroscience.2006.08.040. PMC 1748954. PMID 17027167.

[pmid12399951-7] Wersinger SR, Ginns EI, O'Carroll AM, Lolait SJ, Young WS (2002). "AVPR1B knockout reduces aggressive behavior in male mice". Mol. Psychiatry 7 (9): 975–84. doi:10.1038/sj.mp.4001195. PMID 12399951.

[pmid17284170-8] Wersinger SR, Caldwell HK, Christiansen M, Young WS (2007). "Disruption of the Vasopressin 1b Receptor Gene Impairs the Attack Component of Aggressive Behavior in Mice". Genes, Brain and Behavior 6 (7): 653–60. doi:10.1111/j.1601-183X.2006.00294.x. PMC 2486432. PMID 17284170.

[pmid15555506-9] Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS (2004). "Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task". Hormones and Behavior 46 (5): 638–45. doi:10.1016/j.yhbeh.2004.07.004. PMID 15555506.

[pmid15652395-10] Blanchard RJ, Griebel G, Farrokhi C, Markham C, Yang M, Blanchard DC (2005). "AVP V_1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters". Pharmacol. Biochem. Behav. 80 (1): 189–94. doi:10.1016/j.pbb.2004.10.024. PMID 15652395.

[pmid15867952-11] Serradeil-Le Gal C, Wagnon J, Tonnerre B, Roux R, Garcia G, Griebel G, Aulombard A (2005). "An overview of SSR149415, a selective nonpeptide vasopressin V_1b receptor antagonist for the treatment of stress-related disorders". CNS Drug Reviews 11 (1): 53–68. doi:10.1111/j.1527-3458.2005.tb00035.x. PMID 15867952.

[pmid17122081-12] Lolait SJ, Stewart LQ, Jessop DS, Young WS, O'Carroll AM (2007). "The Hypothalamic-Pituitary-Adrenal Axis Response to Stress in Mice Lacking Functional Vasopressin V1b Receptors". Endocrinology 148 (2): 849–56. doi:10.1210/en.2006-1309. PMC 2040022. PMID 17122081.

[pmid9425403-13] Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolio B, Grossman AB, Reincke M (1997). "Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro". Clin. Endocrinol. (Oxf) 47 (5): 623–7. doi:10.1046/j.1365-2265.1997.3091129.x. PMID 9425403.

[pmid8636444-14] Keyzer Y, Lenne F, Auzan C, Jégou S, René P, Vaudry H, Kuhn JM, Luton JP, Clauser E, Bertagna X (1996). "The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome". J. Clin. Invest. 97 (5): 1311–8. doi:10.1172/JCI118547. PMC 507185. PMID 8636444.

[pmid11861823-15] Serradeil-Le Gal C, Wagnon J, Simiand J, Griebel G, Lacour C, Guillon G, Barberis C, Brossard G, Soubrié P, Nisato D, Pascal M, Pruss R, Scatton B, Maffrand JP, Le Fur G (2002). "Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V_1b receptor antagonist". J. Pharmacol. Exp. Ther. 300 (3): 1122–30. doi:10.1124/jpet.300.3.1122. PMID 11861823.

[pmid17495006-16] Pena A, Murat B, Trueba M, Ventura MA, Bertrand G, Cheng LL, Stoev S, Szeto HH, Wo N, Brossard G, Serradeil-Le Gal C, Manning M, Guillon G (2007). "Pharmacological and physiological characterization of d[Leu⁴, Lys⁸]vasopressin, the first V_1b-selective agonist for rat vasopressin/oxytocin receptors". Endocrinology 148 (9): 4136–46. doi:10.1210/en.2006-1633. PMID 17495006.

[pmid20472303-17] van West D, Del-Favero J, Deboutte D, Van Broeckhoven C, Claes S (August 2010). "Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population". Psychiatry Res 179 (1): 64–8. doi:10.1016/j.psychres.2009.04.002. PMID 20472303.

[pmid11884209-18] Zemo DA, McCabe JT (2001). "Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus". Neuropeptides 35 (3-4): 181–8. doi:10.1054/npep.2001.0864. PMID 11884209.

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V1b vasopressin receptor