WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
(genetics) the organic process whereby the DNA sequence in a gene is copied into mRNA; the process whereby a base sequence of messenger RNA is synthesized on a template of complementary DNA
a sound or television recording (e.g., from a broadcast to a tape recording)
something written, especially copied from one medium to another, as a typewritten version of dictation (同)written text
the 19th letter of the Roman alphabet (同)s

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
〈U〉(…を)書き写す(書き直す)こと,(…の)転写,謄写《+of+名》 / 〈C〉写し(書き直し)[たもの] / 〈U〉〈C〉編曲[されたもの] / 〈U〉〈C〉(ラジオ・テレビの)録音(録画)
sulfurの化学記号 / {略}South[ern]

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/23 02:12:57」(JST)

Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.^[1]^[2]

Sp4 transcription factor has been shown to interact with E2F1.^[3]

^ Hagen G, Muller S, Beato M, Suske G (Jan 1993). "Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes". Nucleic Acids Res 20 (21): 5519–25. doi:10.1093/nar/20.21.5519. PMC 334381. PMID 1454515.
^ "Entrez Gene: SP4 Sp4 transcription factor".
^ Rotheneder, H; Geymayer S, Haidweger E (Nov 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. (ENGLAND) 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. ISSN 0022-2836. PMID 10547281. Cite uses deprecated parameters (help)

Sp4 Transcription Factor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on chromosome 7 is a stub. You can help Wikipedia by expanding it.

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Nuclear respiratory factor 2 regulates the transcription of AMPA receptor subunit GluA2 (Gria2).

Priya A1, Johar K1, Nair B1, Wong-Riley MT2.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Dec;1843(12):3018-28. doi: 10.1016/j.bbamcr.2014.09.006. Epub 2014 Sep 22.
Neuronal activity is highly dependent on energy metabolism. Nuclear respiratory factor 2 (NRF-2) tightly couples neuronal activity and energy metabolism by transcriptionally co-regulating all 13 subunits of an important energy-generating enzyme, cytochrome c oxidase (COX), as well as critical subuni
PMID 25245478

Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia.

Pinacho R1, Valdizán EM2, Pilar-Cuellar F2, Prades R3, Tarragó T4, Haro JM1, Ferrer I5, Ramos B6.
Journal of psychiatric research.J Psychiatr Res.2014 Nov;58:189-96. doi: 10.1016/j.jpsychires.2014.08.006. Epub 2014 Aug 19.
Altered levels of transcription factor specificity protein 4 (SP4) and 1 (SP1) in the cerebellum, prefrontal cortex and/or lymphocytes have been reported in severe psychiatric disorders, including early psychosis, bipolar disorder, and chronic schizophrenia subjects who have undergone long-term anti
PMID 25175639

Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer: ROLE OF SPECIFICITY PROTEIN (Sp) TRANSCRIPTION FACTORS.

Nair V1, Sreevalsan S1, Basha R2, Abdelrahim M2, Abudayyeh A3, Rodrigues Hoffman A4, Safe S5.
The Journal of biological chemistry.J Biol Chem.2014 Oct 3;289(40):27692-701. doi: 10.1074/jbc.M114.592576. Epub 2014 Aug 20.
The antidiabetic drug metformin exhibits both chemopreventive and chemotherapeutic activity for multiple cancers including pancreatic cancer; however, the underlying mechanism of action of metformin is unclear. A recent study showed that metformin down-regulated specificity protein (Sp) transcriptio
PMID 25143389

Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene

Sp4 transcription factor
	; PDB rendering based on 1va1.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1va1
Identifiers
Symbols	SP4 (; HF1B; SPR-1)
External IDs	OMIM: 600540 MGI: 107595 HomoloGene: 2341 GeneCards: SP4 Gene
Gene Ontology
Molecular function	• DNA binding; • sequence-specific DNA binding transcription factor activity; • transcription coactivator activity; • zinc ion binding;
Cellular component	• nucleus;
Biological process	• transcription, DNA-dependent; • regulation of transcription from RNA polymerase II promoter;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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