Sp4 transcription factor

転写因子Sp4

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. (genetics) the organic process whereby the DNA sequence in a gene is copied into mRNA; the process whereby a base sequence of messenger RNA is synthesized on a template of complementary DNA
12. a sound or television recording (e.g., from a broadcast to a tape recording)
13. something written, especially copied from one medium to another, as a typewritten version of dictation (同)written text
14. the 19th letter of the Roman alphabet (同)s

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 〈U〉(…を)書き写す(書き直す)こと,(…の)転写,謄写《+of+名》 / 〈C〉写し(書き直し)[たもの] / 〈U〉〈C〉編曲[されたもの] / 〈U〉〈C〉(ラジオ・テレビの)録音(録画)
4. sulfurの化学記号 / {略}South[ern]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/23 02:12:57」(JST)

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[Wiki en表示]

Sp4 transcription factor
PDB rendering based on 1va1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1va1
Identifiers
Symbols	SP4 (; HF1B; SPR-1)
External IDs	OMIM: 600540 MGI: 107595 HomoloGene: 2341 GeneCards: SP4 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • zinc ion binding Cellular component • nucleus Biological process • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6671	20688
Ensembl	ENSG00000105866	ENSMUSG00000025323
UniProt	Q02446	Q62445
RefSeq (mRNA)	NM_003112	NM_001166385
RefSeq (protein)	NP_003103	NP_001159857
Location (UCSC)	Chr 7: 21.47 – 21.55 Mb	Chr 12: 118.23 – 118.3 Mb
PubMed search	[1]	[2]

Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.

Interactions

Sp4 transcription factor has been shown to interact with E2F1.

References

Further reading

• Suske G (1999). "The Sp-family of transcription factors.". Gene 238 (2): 291–300. doi:10.1016/S0378-1119(99)00357-1. PMID 10570957. 
• Hagen G, Dennig J, Preiss A, et al. (1995). "Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.". J. Biol. Chem. 270 (42): 24989–94. doi:10.1074/jbc.270.42.24989. PMID 7559627. 
• Kalff-Suske M, Kunz J, Grzeschik KH, Suske G (1995). "Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15.". Genomics 26 (3): 631–3. doi:10.1016/0888-7543(95)80191-N. PMID 7607696. 
• Majello B, De Luca P, Hagen G, et al. (1995). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.". Nucleic Acids Res. 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMC 523756. PMID 7800480. 
• Rotheneder H, Geymayer S, Haidweger E (2000). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281. 
• Nguyên-Trân VT, Kubalak SW, Minamisawa S, et al. (2000). "A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.". Cell 102 (5): 671–82. doi:10.1016/S0092-8674(00)00089-1. PMID 11007485. 
• Lerner LE, Gribanova YE, Ji M, et al. (2001). "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements.". J. Biol. Chem. 276 (37): 34999–5007. doi:10.1074/jbc.M103301200. PMID 11438531. 
• Lerner LE, Gribanova YE, Whitaker L, et al. (2002). "The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX.". J. Biol. Chem. 277 (29): 25877–83. doi:10.1074/jbc.M201407200. PMID 11943774. 
• Lee DK, Suh D, Edenberg HJ, Hur MW (2002). "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.". J. Biol. Chem. 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059. 
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.". Mol. Vis. 8: 196–204. PMID 12107411. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Davis W, Chen ZJ, Ile KE, Tew KD (2003). "Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.". Nucleic Acids Res. 31 (3): 1097–107. doi:10.1093/nar/gkg192. PMC 149212. PMID 12560508. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Hong J, Samudio I, Liu S, et al. (2004). "Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins.". Endocrinology 145 (12): 5774–85. doi:10.1210/en.2004-0686. PMID 15345676. 
• Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, et al. (2005). "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases.". J. Clin. Endocrinol. Metab. 90 (6): 3479–90. doi:10.1210/jc.2004-1962. PMID 15788387. 
• Higgins KJ, Liu S, Abdelrahim M, et al. (2006). "Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.". Endocrinology 147 (7): 3285–95. doi:10.1210/en.2006-0081. PMID 16574784. 
• Gao YQ, Danciger M, Ozgul RK, et al. (2007). "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease.". Mol. Vis. 13: 287–92. PMC 2633482. PMID 17356515. 

External links

• Sp4 Transcription Factor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

• Nuclear respiratory factor 2 regulates the transcription of AMPA receptor subunit GluA2 (Gria2).

• Priya A1, Johar K1, Nair B1, Wong-Riley MT2.
• Biochimica et biophysica acta.Biochim Biophys Acta.2014 Dec;1843(12):3018-28. doi: 10.1016/j.bbamcr.2014.09.006. Epub 2014 Sep 22.
• Neuronal activity is highly dependent on energy metabolism. Nuclear respiratory factor 2 (NRF-2) tightly couples neuronal activity and energy metabolism by transcriptionally co-regulating all 13 subunits of an important energy-generating enzyme, cytochrome c oxidase (COX), as well as critical subuni
• PMID 25245478

• Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia.

• Pinacho R1, Valdizán EM2, Pilar-Cuellar F2, Prades R3, Tarragó T4, Haro JM1, Ferrer I5, Ramos B6.
• Journal of psychiatric research.J Psychiatr Res.2014 Nov;58:189-96. doi: 10.1016/j.jpsychires.2014.08.006. Epub 2014 Aug 19.
• Altered levels of transcription factor specificity protein 4 (SP4) and 1 (SP1) in the cerebellum, prefrontal cortex and/or lymphocytes have been reported in severe psychiatric disorders, including early psychosis, bipolar disorder, and chronic schizophrenia subjects who have undergone long-term anti
• PMID 25175639

• Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer: ROLE OF SPECIFICITY PROTEIN (Sp) TRANSCRIPTION FACTORS.

• Nair V1, Sreevalsan S1, Basha R2, Abdelrahim M2, Abudayyeh A3, Rodrigues Hoffman A4, Safe S5.
• The Journal of biological chemistry.J Biol Chem.2014 Oct 3;289(40):27692-701. doi: 10.1074/jbc.M114.592576. Epub 2014 Aug 20.
• The antidiabetic drug metformin exhibits both chemopreventive and chemotherapeutic activity for multiple cancers including pancreatic cancer; however, the underlying mechanism of action of metformin is unclear. A recent study showed that metformin down-regulated specificity protein (Sp) transcriptio
• PMID 25143389

Japanese Journal

• Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene

• GOLLNER H.
• Genes Cells 6, 689-697, 2001
• NAID 80012657000

Related Links

• Sp4 transcription factor - definition of Sp4 transcription factor ...

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• transcription factor Sp4 - definition of transcription factor Sp4 ...

SP4 SP4 A gene on chromosome 7p15.3 that encodes a protein which binds to GT- and GC-box promoter elements and may activate transcription.

Related Pictures

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★リンクテーブル★

リンク元	「転写因子Sp4」
関連記事	「fact」「factor」「transcription factor」「S」

「転写因子Sp4」

　　[★]

英

Sp4 transcription factor

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「transcription factor」

　　[★]

• 転写制御因子、転写因子

関

TF、transcriptional regulator、transcriptional regulatory element

「S」

　　[★]

• セリン serine
• 胸骨上縁