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- 1. 緩和ケアにおける包括的患者評価の概要 overview of comprehensive patient assessment in palliative care
English Journal
- Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type.
- Gutierres JM1, Carvalho FB2, Schetinger MR2, Marisco P2, Agostinho P3, Rodrigues M2, Rubin MA2, Schmatz R2, da Silva CR2, de P Cognato G4, Farias JG2, Signor C2, Morsch VM2, Mazzanti CM2, Bogo M4, Bonan CD4, Spanevello R5.Author information 1Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900 Santa Maria, RS, Brazil. Electronic address: jessiegutierres@hotmail.com.2Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900 Santa Maria, RS, Brazil.3Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.4Laboratório de Neuroquímica e Psicofarmacologia, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619-900 Porto Alegre, RS, Brazil.5Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário-Capão do Leão, 96010-900 Pelotas, RS, Brazil.AbstractAIMS: The aim of this study was to analyze if the pre-administration of anthocyanin on memory and anxiety prevented the effects caused by intracerebroventricular streptozotocin (icv-STZ) administration-induced sporadic dementia of Alzheimer's type (SDAT) in rats. Moreover, we evaluated whether the levels of nitrite/nitrate (NOx), Na(+),K(+)-ATPase, Ca(2+)-ATPase and acethylcholinesterase (AChE) activities in the cerebral cortex (CC) and hippocampus (HC) are altered in this experimental SDAT.
- Life sciences.Life Sci.2014 Feb 6;96(1-2):7-17. doi: 10.1016/j.lfs.2013.11.014. Epub 2013 Nov 28.
- AIMS: The aim of this study was to analyze if the pre-administration of anthocyanin on memory and anxiety prevented the effects caused by intracerebroventricular streptozotocin (icv-STZ) administration-induced sporadic dementia of Alzheimer's type (SDAT) in rats. Moreover, we evaluated whether the l
- PMID 24291256
- Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer's type (SDAT) caused by intracerebroventricular streptozotocin in rats.
- Javed H1, Khan A, Vaibhav K, Moshahid Khan M, Ahmad A, Ejaz Ahmad M, Ahmad A, Tabassum R, Islam F, Safhi MM, Islam F.Author information 1Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, 110062, India.AbstractOxidative loads in the brain are involved in age related impairments like learning and memory as well as neurodegeneration. Taurine, the most abundant free amino acid in humans has many potential health benefits through its anti-oxidant and anti-inflammatory properties. Therefore, we investigated the neuroprotective potential of taurine on oxidative stress, neuronal loss and memory impairments in streptozotocin model of cognitive impairments in rats. The cognitive impairment was developed by giving single intracerebroventricular (ICV) injection of streptozotocin (STZ) 3 mg/kg body weight bilaterally. An increased latency and path length was observed in ICV-STZ group animals as compared to sham group animals and these were inhibited significantly in STZ group pre-treated with taurine (50 mg/kg body weight orally once daily for 15 days). Moreover, the significantly depleted content of GSH and elevated level of thiobarbituric acid reactive substances (TBARS) in ICV-STZ group animals were protected significantly with pre-treatment of taurine. The activity of antioxidant enzymes, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, catalase, and superoxide dismutase was decreased in STZ group as compared to sham group and pre-treatment of STZ group with taurine has protected their activities significantly. Furthermore, the increased activity of acetylcholine esterase and decreased expression of choline acetyl transferase were attenuated by the pre-treatment of taurine. Taurine also protected the morphology of the hippocampal pyramidal neurons. This study concludes that the prophylactic intervention of taurine may be used to prevent the deterioration of cognitive functions and neurobehavioral activities, often associated with the generation of free radicals.
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.Neurol Sci.2013 Dec;34(12):2181-92. doi: 10.1007/s10072-013-1444-3. Epub 2013 May 17.
- Oxidative loads in the brain are involved in age related impairments like learning and memory as well as neurodegeneration. Taurine, the most abundant free amino acid in humans has many potential health benefits through its anti-oxidant and anti-inflammatory properties. Therefore, we investigated th
- PMID 23681104
Japanese Journal
- 経過と予後 (アルツハイマー病--基礎研究から予防・治療の新しいパラダイム) -- (アルツハイマー病の治療・管理)
- 北村 伸
- 日本臨床 66(-) (929), 428-432, 2008-01
- NAID 40015816123
- アルツハイマー病の分子病態と治療--特にアミロイドβ蛋白を標的として
- 大八木 保政,Ohyagi Yasumasa,オオヤギ ヤスマサ
- 福岡医学雑誌 97(9), 261-268, 2006-09-25
- … 以前は65歳以上の痴呆症は老年痴呆症(senile dementia)と呼ばれていたが, 病理学的共通性から, 現在はアルツハイマー型老年認知症(senile dementia of Alzheimer type, SDAT)と呼ばれている. …
- NAID 120002564571
Related Pictures
★リンクテーブル★
| リンク元 | 「アルツハイマー型認知症」「アルツハイマー型老人性認知症」「アルツハイマー型老年痴呆」「senile dementia of Alzheimer type」 |
| 関連記事 | 「SDA」「SD」 |
「アルツハイマー型認知症」
- 英
- dementia of Alzheimer type, DAT
- 同
- アルツハイマー型痴呆、アルツハイマー病型認知症
- 関
- アルツハイマー病、認知症
- アルツハイマー病(AD)と同じ症状を呈する。しかしADと違って高齢発症する違いがある。
参考
- 1.
「アルツハイマー型老人性認知症」
「アルツハイマー型老年痴呆」
「senile dementia of Alzheimer type」
「SDA」
- セロトニン・ドパミン拮抗薬 セロトニン・ドパミン遮断薬 serotonin-dopamine antagonist
- 特異動的作用 specific dynamic action
- 上十二指腸角 superior duodenal angulus