WordNet

invest with or as with a body; give body to (同)personify
the external structure of a vehicle; "the body of the car was badly rusted"
the main mass of a thing
a natural object consisting of a dead animal or person; "they found the body in the lake" (同)dead body
the entire structure of an organism (an animal, plant, or human being); "he felt as if his whole body were on fire" (同)organic structure, physical structure
a collection of particulars considered as a system; "a body of law"; "a body of doctrine"; "a body of precedents"
a group of persons associated by some common tie or occupation and regarded as an entity; "the whole body filed out of the auditorium"; "the student body"; "administrative body"
an individual 3-dimensional object that has mass and that is distinguishable from other objects; "heavenly body"
the central message of a communication; "the body of the message was short"

PrepTutorEJDIC

〈C〉『身体』,肉体 / 〈C〉(人・動物の)『胴体』 / 〈C〉)物の)『主要部』,本体《+『of』+『名』》 / 〈C〉(…の)『団体』,群れ:(…のたくさんの)集まり《+『of』+『名』》 / 〈C〉物体,…体 / 〈U〉実質;(酒・味などの)こく / 〈C〉《話》人
《英話》人;(特に)男

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/08 17:04:16」(JST)

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Micrograph showing a Mallory body with the characteristic twisted-rope appearance (centre of image - within a ballooning hepatocyte). H&E stain.

In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells.^[1] Mallory bodies are damaged intermediate filaments within the hepatocytes.

Associated conditions

Mallory bodies are classically found in the livers of people suffering from alcoholic liver disease and were once thought to be specific for that.^[2]

They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).^[3]

They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions.^[3] However, it has also been reported in certain other unrelated conditions.^[4]

Appearance

Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate cytokeratin 8/18 filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62.

Eponym

It is named for the American pathologist Frank Burr Mallory, who first described the structures in 1911.^[3]

Additional images

Micrograph showing a Mallory body. Original magnification 400X. H&E stain.
Micrograph showing a Mallory body. Original magnification 200X. H&E stain.
Liver micrograph showing abundant Mallory bodies, as seen in alcohol abuse.
Mallory bodies in hepatocellular carcinoma. Trichrome stain.

References

^ "Cell Injury".
^ Denk, H; Franke, WW; Eckerstorfer, R; Schmid, E; Kerjaschki, D (August 1979). "Formation and involution of Mallory bodies ("alcoholic hyalin") in murine and human liver revealed by immunofluorescence microscopy with antibodies to prekeratin." (PDF). Proceedings of the National Academy of Sciences of the United States of America 76 (8): 4112–6. doi:10.1073/pnas.76.8.4112. PMC 383988. PMID 386356.
^ ^a ^b ^c Jensen, K; Gluud, C (Oct 1994). "The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey).". Hepatology 20 (4 Pt 1): 1061–77. doi:10.1002/hep.1840200440. PMID 7927209.
^ Michel, RP; Limacher, JJ; Kimoff, RJ (January 1982). "Mallory bodies in scar adenocarcinoma of the lung.". Human pathology 13 (1): 81–5. doi:10.1016/S0046-8177(82)80143-3. PMID 6176520.

UpToDate Contents

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English Journal

Understanding the Impact of Obesity on Short-term Outcomes and In-hospital Costs After Instrumented Spinal Fusion.

Higgins DM1, Mallory GW, Planchard RF, Puffer RC, Ali M, Gates MJ, Clifton WE, Jacob JT, Curry TB, Kor DJ, Fogelson JL, Krauss WE, Clarke MJ.
Neurosurgery.Neurosurgery.2016 Jan;78(1):127-32. doi: 10.1227/NEU.0000000000001018.
BACKGROUND: Obesity rates continue to rise along with the number of obese patients undergoing elective spinal fusion.OBJECTIVE: To evaluate the impact of obesity on resource utilization and early complications in patients undergoing surgery for degenerative spine disease.METHODS: A single-institutio
PMID 26352096

Altered regulation of miR-34a and miR-483-3p in alcoholic hepatitis and DDC fed mice.

Liu H1, French BA1, Li J1, Tillman B1, French SW2.
Experimental and molecular pathology.Exp Mol Pathol.2015 Dec;99(3):552-7. doi: 10.1016/j.yexmp.2015.09.005. Epub 2015 Sep 25.
MicroRNAs are small noncoding RNAs that negatively regulate gene expression by binding to the untranslated regions of their target mRNAs. Deregulation of miRNAs is shown to play pivotal roles in tumorigenesis and progression. Mallory-Denk Bodies (MDBs) are prevalent in various liver diseases includi
PMID 26403328

Aberrant modulation of the BRCA1 and G1/S cell cycle pathways in alcoholic hepatitis patients with Mallory Denk Bodies revealed by RNA sequencing.

Liu H1, Gong M2, French BA1, Liao G1, Li J1, Tillman B1, French SW1.
Oncotarget.Oncotarget.2015 Nov 25. doi: 10.18632/oncotarget.6382. [Epub ahead of print]
Mallory-Denk Bodies (MDBs) are prevalent in various liver diseases including alcoholic hepatitis (AH) and are formed in mice livers by feeding DDC. Liver injury from alcohol administration causes balloon hepatocytes and MDB formation impeding liver regeneration. By comparing AH livers where MDBs had
PMID 26623723

Japanese Journal

アルコール性肝障害および非アルコール性脂肪性肝炎の組織学的鑑別 (特集日常臨床のジレンマ : NASHかASHか)

野本実
消化器内科 57(6), 721-727, 2013-12
NAID 40019931343

肝脂肪化とオートファジー不全 (特集肥満と消化器疾患)

稲見義宏,山科俊平,渡辺純夫
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ESDの偶発症としての Mallory-Weiss 症候群に関する検討

河野孝一朗,名和田義高,濱田晃市,田島浩子,西野徳之,中澤敏弘,十林賢児
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 54(4), 1443-1450, 2012-04-20
… ESD時のMallory-Weiss tearについて検討した．ESD自験例207例中の7例（3.4％）にMallloy-Weiss tearを認めた．そのうち，それぞれ1例（14.3％）で裂創部の穿孔と裂創が病変に及ぶことによる治療断念例を認めた．7例全例で内視鏡の押し込み操作を行っていた．危険因子として，BMI 18.5未満の低BMIがオッズ比2.5で有意だった．ESD時のMallory-Weiss tearの発症は稀ではなく，ESDに大きな支障をきたす恐れがある．リスクの …
NAID 10030649554