WordNet

direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
(often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
the 9th letter of the Roman alphabet (同)i
official routes of communication; "you have to go through channels"

PrepTutorEJDIC

〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
『私は』私が
iodineの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/08/05 03:40:56」(JST)

wiki en

[Wiki en表示]

The IK channel (K_Ca3.1), which has a conductance of 20–80 pS, is expressed mainly in peripheral tissues such as those of the haematopoietic system, colon, placenta, lung and pancreas. The K_Ca3.1 channel in red blood cells was the first Ca²⁺–sensitive K⁺ channel to be identified and it has been implicated in a wide range of cell functions, including vasodilation of the microvasculature, K⁺ flux across endothelial cells of brain capillaries and the phagocytic activity of neutrophils. K_Ca3.1 is of primary importance in the relationship between K⁺ channels and cell proliferation.

In the latter case, a human hIKCa1 gene encodes the channel found in T cells, which is responsible for the hyperpolarization that is required to keep Ca²⁺ flowing into the cell through the I_CRAC channels.

In comparison with the large-conductance (BK) channels, K_Ca3.1 is much more sensitive to Ca²⁺ and can thus respond to the global level of Ca²⁺. This high affinity for Ca²⁺ depends upon four resident calmodulin molecules tightly bound to the cytoplasmic tails of the four pore-forming α-subunits. Before the channel can open, Ca²⁺ must bind to each of the calmodulins to induce the co-operative conformational change that opens the gate, which explains why this process has a Hill coefficient of 4. This Ca²⁺–induced gating process resembles that which has been described for the small-conductance (SK) channels. The fact that calmodulin is prebound to its effector enables the channels to respond to Ca²⁺ very quickly.

The PtdIns3P signaling cassette may play a role in regulating the activity of K_Ca3.1. If this signaling lipid is hydrolysed by MTMR6, which is one of the myotubularins, there is a decrease in the activity of the Ca²⁺–activated channel.^[1]

References

^ Berridge, M.J. (2014) Cell Signaling Biology; doi:10.1042/csb0001003

This cell biology article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 赤血球水分量の制御 control of red blood cell hydration
2. 腎集合管ナトリウムチャンネルの遺伝的障害：リドル症候群および偽性低アルドステロン
症1型 genetic disorders of the collecting tubule sodium channel liddles syndrome and pseudohypoaldosteronism type 1
3. 幼児の持続性高インスリン血症性低血糖症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of persistent hyperinsulinemic hypoglycemia of infancy
4. カルシウム拮抗剤の主な副作用および安全性 major side effects and safety of calcium channel blockers
5. 安定狭心症のマネージメントにおけるカルシウム拮抗剤 calcium channel blockers in the management of stable angina pectoris

English Journal

Involvement of the phosphatidylinositol kinase pathway in augmentation of ATP-sensitive K(+) channel currents by hypo-osmotic stress in rat ventricular myocytes.

Mitsuyama H, Yokoshiki H, Irie Y, Watanabe M, Mizukami K, Tsutsui H.SourceDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
Canadian journal of physiology and pharmacology.Can J Physiol Pharmacol.2013 Sep;91(9):686-92. doi: 10.1139/cjpp-2012-0408. Epub 2013 Mar 5.
The objective of this study was to investigate the mechanisms of increase in the efficacy of ATP-sensitive K(+) channel (KATP) openings by hypo-osmotic stress. The whole-cell KATP currents (IK,ATP) stimulated by 100 μmol/L pinacidil, a K(+) channel opening drug, were significantly augmented during
PMID 23984989

Enhanced K+ secretion in dextran sulfate-induced colitis reflects up-regulation of large conductance apical K+ channels (BK; Kcnma1).

Kanthesh BM, Sandle GI, Rajendran VM.SourceWest Virginia Uniersity.
American journal of physiology. Cell physiology.Am J Physiol Cell Physiol.2013 Aug 28. [Epub ahead of print]
Defective colonic Na+ and Cl- absorption is a feature of active ulcerative colitis (UC), but little is known about changes in colonic K+ transport. We therefore investigated colonic K+ transport in a rat model of dextran sulfate-induced colitis. Colitis was induced in rat distal colon using 5% dextr
PMID 23986198

Extracts from Leonurus sibiricus L. increase insulin secretion and proliferation of rat INS-1E insulinoma cells.

Schmidt S, Jakab M, Jav S, Streif D, Pitschmann A, Zehl M, Purevsuren S, Glasl S, Ritter M.SourceInstitute of Physiology and Pathophysiology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria. Electronic address: sabine.schmidt@pmu.ac.at.
Journal of ethnopharmacology.J Ethnopharmacol.2013 Aug 24. pii: S0378-8741(13)00555-2. doi: 10.1016/j.jep.2013.08.013. [Epub ahead of print]
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Mongolian medicine (TMM) uses preparations from herbs as one form of medication for the treatment of a diversity of diseases including diabetes mellitus (DM). We evaluated the effect of extracts from the plant Leonurus sibiricus L. (LS), used in TMM to tre
PMID 23978659

Japanese Journal

Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K⁺ Channel, I[K.ACh]

Circulation Journal 80(6), 1346-1355, 2016
NAID 130005153582

Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K+ Channel, IK.ACh

Circulation Journal advpub(0), 2016
NAID 130005151345

Subthreshold 8T SRAM sizing utilizing short-channel Vt roll-off and inverse narrow-width effect

IEICE Electronics Express 13(8), 20160020-20160020, 2016
NAID 130005147717

Related Pictures

★リンクテーブル★

リンク元	「中間コンダクタンスカルシウム活性化カリウムチャネル」「中間コンダクタンスカリウムチャネル」「intermediate-conductance calcium-activated potassium channel」
関連記事	「channel」「I」