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Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway.

Li Y1, Zhang ZN, Zhao HM, Tong ZC, Yang J, Wang H, Liang XJ.
Anti-cancer drugs.Anticancer Drugs.2014 Oct;25(9):1035-43. doi: 10.1097/CAD.0000000000000136.
Matrine has been used in anti-inflammatory and anticancer therapies for a long time. However, the antimetastatic effect and molecular mechanism(s) of matrine on osteosarcoma are still unclear. Therefore, the aim of this study was to assess the effects of matrine and related mechanism(s) on osteosarc
PMID 24999836

IκB Kinase β (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor κB (NFκB) Signaling.

Kai X1, Chellappa V1, Donado C1, Reyon D2, Sekigami Y1, Ataca D1, Louissaint A3, Mattoo H1, Joung JK4, Pillai S5.
The Journal of biological chemistry.J Biol Chem.2014 Sep 26;289(39):26960-72. doi: 10.1074/jbc.M114.598763. Epub 2014 Aug 8.
Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKβ), the critical activating kinase in canonical (NFκB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma. Lysine 171 forms part of a cationic pocket that interacts with the activation loop
PMID 25107905

Cell migration to CXCL12 requires simultaneous IKKα and IKKβ-dependent NF-κB signaling.

Penzo M1, Habiel DM2, Ramadass M2, Kew RR2, Marcu KB3.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Sep;1843(9):1796-804. doi: 10.1016/j.bbamcr.2014.04.011. Epub 2014 Apr 18.
CXCL12 and its unique receptor CXCR4, is critical for the homing of a variety of cell lineages during both development and tissue repair. CXCL12 is particularly important for the recruitment of hemato/lymphopoietic cells to their target organs. In conjunction with the damage-associated alarmin molec
PMID 24747690

Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α.

Takano Mariko,Otsuka Fumio,Matsumoto Yoshinori,Inagaki Kenichi,Takeda Masaya,Nakamura Eri,Tsukamoto Naoko,Miyoshi Tomoko,Sada Ken-ei,Makino Hirofumi
Molecular and Cellular Endocrinology 348(1), 224-232, 2012-01-02
… Furthermore, TNF-alpha-induced phosphorylation of MAPKs, NF kappa B, I kappa B and Stat pathways was inhibited in the presence of PPAR alpha and PPAR gamma agonists with reducing TNF-alpha receptor expression. … Stat and NF kappa B pathways reversed the TNF-alpha suppression of osteoblast differentiation, we conclude that these cascades are functionally involved in the actions of PPARs that antagonize TNF-alpha-induced suppression of osteoblast differentiation. …
NAID 120005232493

PPAR alpha Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-kappa B Signaling

Hashimoto Koji,Kamijo Yuji,Nakajima Takero,Harada Makoto,Higuchi Makoto,Ehara Takashi,Shigematsu Hidekazu,Aoyama Toshifumi
PPAR RESEARCH, 976089, 2012
… The PPAR alpha activation appeared to suppress the NF-kappa B signaling pathway in glomeruli by the induction of I kappa B alpha, resulting in the reduction of proteinuria and the amelioration of the active inflammatory pathologic glomerular changes. …
NAID 120005647605

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

Miyashita Moeko,Oshiumi Hiroyuki,Matsumoto Misako,Seya Tsukasa
Molecular and Cellular Biology 31(18), 3802-3819, 2011-09
… The cytoplasmic viral RNA sensors RIG-I and MDA5 are important for the production of type I interferon and other inflammatory cytokines. … After viral infection, the DDX60 protein binds to endogenous RIG-I protein. … The protein also binds to MDA5 and LGP2 but not to the downstream factors IPS-1 and I kappa B kinase epsilon (IKK-epsilon). …
NAID 120003837189