WordNet
- the 2nd letter of the Roman alphabet (同)b
- the blood group whose red cells carry the B antigen (同)type_B, group B
- the 9th letter of the Roman alphabet (同)i
- the 10th letter of the Greek alphabet
PrepTutorEJDIC
- 『私は』私が
- iodineの化学記号
- カッパ(ギリシア語アルファベットの第10字Κ,k;英語の『K,k』に相当)
UpToDate Contents
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- 1. モノクローナル蛋白の認識 recognition of monoclonal proteins
- 2. 複合免疫不全 combined immunodeficiencies
- 3. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy
- 4. 多発性骨髄腫の臨床的特徴、検査所見、および診断 clinical features laboratory manifestations and diagnosis of multiple myeloma
- 5. Use of opioids in the management of chronic non-cancer pain
English Journal
- Matrine inhibits the invasive properties of human osteosarcoma cells by downregulating the ERK-NF-κB pathway.
- Li Y1, Zhang ZN, Zhao HM, Tong ZC, Yang J, Wang H, Liang XJ.
- Anti-cancer drugs.Anticancer Drugs.2014 Oct;25(9):1035-43. doi: 10.1097/CAD.0000000000000136.
- Matrine has been used in anti-inflammatory and anticancer therapies for a long time. However, the antimetastatic effect and molecular mechanism(s) of matrine on osteosarcoma are still unclear. Therefore, the aim of this study was to assess the effects of matrine and related mechanism(s) on osteosarc
- PMID 24999836
- IκB Kinase β (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor κB (NFκB) Signaling.
- Kai X1, Chellappa V1, Donado C1, Reyon D2, Sekigami Y1, Ataca D1, Louissaint A3, Mattoo H1, Joung JK4, Pillai S5.
- The Journal of biological chemistry.J Biol Chem.2014 Sep 26;289(39):26960-72. doi: 10.1074/jbc.M114.598763. Epub 2014 Aug 8.
- Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKβ), the critical activating kinase in canonical (NFκB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma. Lysine 171 forms part of a cationic pocket that interacts with the activation loop
- PMID 25107905
- Cell migration to CXCL12 requires simultaneous IKKα and IKKβ-dependent NF-κB signaling.
- Penzo M1, Habiel DM2, Ramadass M2, Kew RR2, Marcu KB3.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Sep;1843(9):1796-804. doi: 10.1016/j.bbamcr.2014.04.011. Epub 2014 Apr 18.
- CXCL12 and its unique receptor CXCR4, is critical for the homing of a variety of cell lineages during both development and tissue repair. CXCL12 is particularly important for the recruitment of hemato/lymphopoietic cells to their target organs. In conjunction with the damage-associated alarmin molec
- PMID 24747690
Japanese Journal
- Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α.
- Takano Mariko,Otsuka Fumio,Matsumoto Yoshinori,Inagaki Kenichi,Takeda Masaya,Nakamura Eri,Tsukamoto Naoko,Miyoshi Tomoko,Sada Ken-ei,Makino Hirofumi
- Molecular and Cellular Endocrinology 348(1), 224-232, 2012-01-02
- … Furthermore, TNF-alpha-induced phosphorylation of MAPKs, NF kappa B, I kappa B and Stat pathways was inhibited in the presence of PPAR alpha and PPAR gamma agonists with reducing TNF-alpha receptor expression. … Stat and NF kappa B pathways reversed the TNF-alpha suppression of osteoblast differentiation, we conclude that these cascades are functionally involved in the actions of PPARs that antagonize TNF-alpha-induced suppression of osteoblast differentiation. …
- NAID 120005232493
- PPAR alpha Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-kappa B Signaling
- Hashimoto Koji,Kamijo Yuji,Nakajima Takero,Harada Makoto,Higuchi Makoto,Ehara Takashi,Shigematsu Hidekazu,Aoyama Toshifumi
- PPAR RESEARCH, 976089, 2012
- … The PPAR alpha activation appeared to suppress the NF-kappa B signaling pathway in glomeruli by the induction of I kappa B alpha, resulting in the reduction of proteinuria and the amelioration of the active inflammatory pathologic glomerular changes. …
- NAID 120005647605
- DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling
- Miyashita Moeko,Oshiumi Hiroyuki,Matsumoto Misako,Seya Tsukasa
- Molecular and Cellular Biology 31(18), 3802-3819, 2011-09
- … The cytoplasmic viral RNA sensors RIG-I and MDA5 are important for the production of type I interferon and other inflammatory cytokines. … After viral infection, the DDX60 protein binds to endogenous RIG-I protein. … The protein also binds to MDA5 and LGP2 but not to the downstream factors IPS-1 and I kappa B kinase epsilon (IKK-epsilon). …
- NAID 120003837189
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Related Pictures
![kappa]B[alpha]- and A20-dependent](https://1mg.info/0/9/w/0596.jpg)
★リンクテーブル★
| リンク元 | 「IκB」 |
| 拡張検索 | 「I-kappa B protein」 |
| 関連記事 | 「B」「I」「Id」「kappa」 |
「IκB」
「I-kappa B protein」
「B」
- 気管分岐部下緑
- 補体のalternative pathwayに関わる蛋白質
- Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する
「I」