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- the 8th letter of the Roman alphabet (同)h
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- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/09 22:59:30」(JST)
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- 1. 急性重度外傷性脳損傷のマネージメント management of acute severe traumatic brain injury
- 2. 見かけの鉱質コルチコイド過剰（AME）症候群（長期甘草摂取を含む） apparent mineralocorticoid excess syndromes including chronic licorice ingestion
- 3. 多嚢胞性卵巣症候群におけるステロイドホルモン代謝 steroid hormone metabolism in polycystic ovary syndrome
- 4. 男性生殖生理学 male reproductive physiology
English Journal
- Zearalenone inhibits testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and orphan nuclear receptor Nur77 expression.
- Liu Q1, Wang Y1, Gu J1, Yuan Y1, Liu X1, Zheng W1, Huang Q1, Liu Z1, Bian J2.Author information 1College of Veterinary Medicine, Yangzhou University, 12 East, Wenhui Road, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.2College of Veterinary Medicine, Yangzhou University, 12 East, Wenhui Road, Yangzhou 225009, Jiangsu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address: jcbian@yzu.edu.cn.AbstractZearalenone (ZEA) directly inhibits testosterone biosynthesis in Leydig cells, although the mechanisms involved remains unclear. Various experiments were performed to elucidate the molecular pathway of ZEA-mediated androgen inhibition. Leydig cells were isolated from 6week-old male ICR mice and subjected to ZEA pre-treatment. The levels of testosterone and a series of influncing factors were measured. The results showed that ZEA caused a concentration- and time-dependent inhibition of testosterone stimulated both by hCG and cAMP (P<0.05). Exposure to ZEA did not affect the LHR binding activity nor the protein expression (P>0.05). However, ZEA exposure significantly elevated the cellular cAMP levels (P<0.05) in low concentrations (5μg/ml) or for long time periods (24h), significantly reduce the mitochondrial membrane potential (P<0.05). The expression of P450scc, 17β-HSD, and P450c17 at the mRNA level were significantly decreased (P<0.05). The steroidogenic acute regulatory (StAR) and 3β-HSD expression was significantly increased (P<0.05). Furthermore, the ERα protein expression was not affected by ZEA, but Nur77 expression was significantly inhibited (P<0.05). These observations imply that ZEA activity interferes with testosterone biosynthesis in mouse Leydig cells via the crosstalk of estrogen receptor signaling and Nur77 expression.
- Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2014 Jun;28(4):647-56. doi: 10.1016/j.tiv.2014.01.013. Epub 2014 Feb 7.
- Zearalenone (ZEA) directly inhibits testosterone biosynthesis in Leydig cells, although the mechanisms involved remains unclear. Various experiments were performed to elucidate the molecular pathway of ZEA-mediated androgen inhibition. Leydig cells were isolated from 6week-old male ICR mice and subj
- PMID 24512812
- Reducing maternal depressive symptoms through promotion of parenting in pediatric primary care.
- Berkule SB1, Cates CB, Dreyer BP, Huberman HS, Arevalo J, Burtchen N, Weisleder A, Mendelsohn AL.Author information 11New York University School of Medicine/Bellevue Hospital Center, New York, NY, USA.AbstractWe studied associations between 2 pediatric primary care interventions promoting parental responsiveness and maternal depressive symptoms among low-income mothers. This randomized controlled trial included 2 interventions (Video Interaction Project [VIP], Building Blocks [BB]) and a control group. VIP is a relationship-based intervention, using video-recordings of mother-child dyads to reinforce interactional strengths. BB communicates with parents via parenting newsletters, learning materials, and questionnaires. At mean (SD) child age 6.9 (1.2) months, depressive symptoms were assessed with the Patient Health Questionnaire-9 (PHQ-9), parental responsiveness was assessed with StimQ-I. A total of 407 dyads were assessed. Rates of mild depressive symptoms were lower for VIP (20.6%) and BB (21.1%) than Controls (32.1%, P = .04). Moderate depressive symptoms were lower for VIP (4.0%) compared to Controls (9.7%, P = .031). Mean PHQ-9 scores differed across 3 groups (F = 3.8, P = .02): VIP mothers scored lower than controls (P = .02 by Tukey HSD). Parent-child interactions partially mediated VIP-associated reductions in depressive symptoms (indirect effect -.17, 95% confidence interval -.36, -.03).
- Clinical pediatrics.Clin Pediatr (Phila).2014 May;53(5):460-9. doi: 10.1177/0009922814528033.
- We studied associations between 2 pediatric primary care interventions promoting parental responsiveness and maternal depressive symptoms among low-income mothers. This randomized controlled trial included 2 interventions (Video Interaction Project [VIP], Building Blocks [BB]) and a control group. V
- PMID 24707022
- Plasminogen activator inhibitor-1 deficiency ameliorates insulin resistance and hyperlipidemia but not bone loss in obese female mice.
- Tamura Y1, Kawao N, Yano M, Okada K, Matsuo O, Kaji H.Author information 1Department of Physiology and Regenerative Medicine (Y.T., N.K., M.Y., K.O., H.K.), Kinki University Faculty of Medicine (O.M.), Osakasayama 589-8511, Japan.AbstractWe previously demonstrated that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is involved in type 1 diabetic bone loss in female mice. PAI-1 is well known as an adipogenic factor induced by obesity. We therefore examined the effects of PAI-1 deficiency on bone and glucose and lipid metabolism in high-fat and high-sucrose diet (HF/HSD)-induced obese female mice. Female wild-type (WT) and PAI-1-deficient mice were fed with HF/HSD or normal diet for 20 weeks from 10 weeks of age. HF/HSD increased the levels of plasma PAI-1 in WT mice. PAI-1 deficiency suppressed the levels of blood glucose, plasma insulin, and total cholesterol elevated by obesity. Moreover, PAI-1 deficiency improved glucose intolerance and insulin resistance induced by obesity. Bone mineral density (BMD) at trabecular bone as well as the levels of osterix, alkaline phosphatase, and receptor activator of nuclear factor κB ligand mRNA in tibia were decreased by HF/HSD in WT mice, and those changes by HF/HSD were not affected by PAI-1 deficiency. HF/HSD increased the levels of plasma TNF-α in both WT and PAI-1-deficient mice, and the levels of plasma TNF-α were negatively correlated with trabecular BMD in tibia of female mice. In conclusion, we revealed that PAI-1 deficiency does not affect the trabecular bone loss induced by obesity despite the amelioration of insulin resistance and hyperlipidemia in female mice. Our data suggest that the changes of BMD and bone metabolism by obesity might be independent of PAI-1 as well as glucose and lipid metabolism.
- Endocrinology.Endocrinology.2014 May;155(5):1708-17. doi: 10.1210/en.2013-1888. Epub 2014 Feb 28.
- We previously demonstrated that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is involved in type 1 diabetic bone loss in female mice. PAI-1 is well known as an adipogenic factor induced by obesity. We therefore examined the effects of PAI-1 deficiency on bone and glucose
- PMID 24605827
Japanese Journal
- 清涼飲料水が象牙質の硬度に与える影響
- 藤田 恵未,犬飼 順子,中垣 晴男,向井 正視
- 口腔衛生学会雑誌 63(3), 280-285, 2013-04-30
- … フルーツジュース,ヨーグルト飲料,炭酸飲料,蒸留水の5種試験飲料に浸漬し,経時的に試料のヌープ硬さを測定した.また,浸漬30分後の試料は二次電子像観察を行った.結果は経時的に一元配置分散分析およびTukey HSDの多重比較を行った.各飲料別のヌープ硬さは浸漬2分後は飲料間に有意差はなく,5分後では蒸留水とグレープフルーツジュース間,および蒸留水と炭酸飲料間で有意差があり,15分後では蒸留水と炭酸飲料間,蒸留 …
- NAID 110009625279
- Involvement of 11β-HSD1 in metabolic syndrome and periodontal disease
- Shiraishi Masanori,Sawai Hirofumi,Nagano Yutaka,Ueda Masatoshi,Umeda Makoto
- Journal of Osaka Dental University 47(1), 7-10, 2013-04-00
- … It has been suggested that 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a glucocorticoid-activating enzyme, plays an important role in metabolic syndrome. … Although the relationship between periodontal disease and metabolic syndrome has been established, the involvement of 11β-HSD1 in periodontal disease has not been reported. … This study was performed to elucidate the role of 11β-HSD1 as a new therapeutic target in periodontal disease. …
- NAID 110009603273
- Effects of aging and irradiation time on the properties of a highly translucent resin-based composite
- BAUER Henrik,ILIE Nicoleta
- Dental Materials Journal 32(4), 592-599, 2013
- … Effects of aging and irradiation time were statistically analyzed using one-way ANOVA with Tukey's HSD post hoc test (α=0.05), partial eta-squared statistic, and Weibull analysis. …
- NAID 130003371092
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- お気軽にご相談ください。 HSDへまずは 一級建築士事務所 東京都知事登録 第51644号 建設業許可 東京都知事 許可(般-20）第121293号 HOME デザインコンセプト 事例 プラン・ケーススタディ HSDとは? HSD開発製品 お問い合わせ ...
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★リンクテーブル★
| リンク元 | 「ハラーフォルデン・シュパッツ病」「hydroxysteroid dehydrogenase」「水酸化ステロイド脱水素酵素」 |
| 拡張検索 | 「11beta-HSD2」「3β-HSD deficiency」「3β-HSD」 |
| 関連記事 | 「HS」「H」 |
「ハラーフォルデン・シュパッツ病」
- 英
- Hallervorden-Spatz disease, HSD
- 同
- 淡蒼球色素変性症 pigmentary degeneration of globus pallidus、Hallervorden-Spatz病 ハラーホルデン・スパッツ病
- 関
- ハラーフォルデン・シュパッツ症候群、パントテン酸キナーゼ関連神経変性症
「hydroxysteroid dehydrogenase」
水酸化ステロイド脱水素酵素、ヒドロキシステロイド脱水素酵素、水酸化ステロイドデヒドロゲナーゼ、ヒドロキシステロイドデヒドロゲナーゼ
- 関
- HSD
「水酸化ステロイド脱水素酵素」
「11beta-HSD2」
- 関
- 11-beta-hydroxysteroid dehydrogenase type 2、11beta-hydroxysteroid dehydrogenase type 2
「3β-HSD deficiency」
「3β-HSD」
「HS」
- ヘパラン硫酸 heparan sulfate heparitin sulfate
- 熱ショック heat shock heat-shock heatshock
- ウマ血清 horse serum
- 遺伝性球状赤血球症 hereditary spherocytosis
「H」