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- JNK
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/29 21:51:26」(JST)
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| Mitogen-activated protein kinase 8 |
PDB rendering based on 1jnk. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE
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| Identifiers |
| Symbols |
MAPK8; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c |
| External IDs |
OMIM: 601158 MGI: 1346861 HomoloGene: 56760 ChEMBL: 2276 GeneCards: MAPK8 Gene |
| EC number |
2.7.11.24 |
| Gene Ontology |
| Molecular function |
• protein serine/threonine kinase activity
• JUN kinase activity
• protein binding
• ATP binding
• histone deacetylase regulator activity
• histone deacetylase binding
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| Cellular component |
• nucleus
• nucleoplasm
• cytosol
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| Biological process |
• toll-like receptor signaling pathway
• MyD88-dependent toll-like receptor signaling pathway
• MyD88-independent toll-like receptor signaling pathway
• apoptotic process
• response to stress
• JNK cascade
• JUN phosphorylation
• Toll signaling pathway
• induction of apoptosis by extracellular signals
• activation of pro-apoptotic gene products
• response to UV
• positive regulation of gene expression
• peptidyl-serine phosphorylation
• peptidyl-threonine phosphorylation
• regulation of histone deacetylation
• negative regulation of protein binding
• regulation of protein localization
• toll-like receptor 1 signaling pathway
• toll-like receptor 2 signaling pathway
• toll-like receptor 3 signaling pathway
• toll-like receptor 4 signaling pathway
• TRIF-dependent toll-like receptor signaling pathway
• negative regulation of apoptotic process
• innate immune response
• nerve growth factor receptor signaling pathway
• regulation of sequence-specific DNA binding transcription factor activity
• stress-activated MAPK cascade
• cellular response to mechanical stimulus
• positive regulation of deacetylase activity
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
5599 |
26419 |
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| Ensembl |
ENSG00000107643 |
ENSMUSG00000021936 |
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| UniProt |
P45983 |
Q91Y86 |
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| RefSeq (mRNA) |
NM_002750.2 |
NM_016700.4 |
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| RefSeq (protein) |
NP_002741.1 |
NP_057909.1 |
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| Location (UCSC) |
Chr 10:
49.51 – 49.65 Mb |
Chr 14:
33.38 – 33.45 Mb |
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| PubMed search |
[1] |
[2] |
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Mitogen-activated protein kinase 8 (also known as JNK1) is an enzyme that in humans is encoded by the MAPK8 gene.[1][2]
The protein encoded by this gene is a member of the MAP kinase and JNK family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported.[3]
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Contents
- 1 Interactions
- 2 References
- 3 External links
- 4 Further reading
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Interactions
MAPK8 has been shown to interact with SPIB,[4] DUSP1,[5] Activating transcription factor 2,[6][7][8][9] SH3BP5,[10] GSTP1,[11] MAPK8IP1,[12][13] MAP2K7,[9][14] CRK,[15] MAP2K4,[8][9][14][16][17] DUSP22,[18] Myc,[19] MAP3K2,[14] DUSP10,[20] REL,[21] MAPK8IP3,[22][23] IRS1,[24][25] MAP3K1[26] and C-jun.[1][9][21][27][28][29][30][31]
References
- ^ a b Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (April 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Cell 76 (6): 1025–37. doi:10.1016/0092-8674(94)90380-8. PMID 8137421.
- ^ Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ (July 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J 15 (11): 2760–70. PMC 450211. PMID 8654373. //www.ncbi.nlm.nih.gov/pmc/articles/PMC450211/.
- ^ "Entrez Gene: MAPK8 mitogen-activated protein kinase 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5599.
- ^ Mao, C; Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene (ENGLAND) 12 (4): 863–73. ISSN 0950-9232. PMID 8632909.
- ^ Slack, D N; Seternes O M, Gabrielsen M, Keyse S M (May. 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". J. Biol. Chem. (United States) 276 (19): 16491–500. doi:10.1074/jbc.M010966200. ISSN 0021-9258. PMID 11278799.
- ^ Raingeaud, J; Gupta S, Rogers J S, Dickens M, Han J, Ulevitch R J, Davis R J (March 1995). "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine". J. Biol. Chem. (UNITED STATES) 270 (13): 7420–6. doi:10.1074/jbc.270.13.7420. ISSN 0021-9258. PMID 7535770.
- ^ Fuchs, S Y; Xie B, Adler V, Fried V A, Davis R J, Ronai Z (December 1997). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors". J. Biol. Chem. (UNITED STATES) 272 (51): 32163–8. doi:10.1074/jbc.272.51.32163. ISSN 0021-9258. PMID 9405416.
- ^ a b Chen, Z; Cobb M H (May. 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. (United States) 276 (19): 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118.
- ^ a b c d Tournier, C; Whitmarsh A J, Cavanagh J, Barrett T, Davis R J (July 1997). "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (14): 7337–42. doi:10.1073/pnas.94.14.7337. ISSN 0027-8424. PMC 23822. PMID 9207092. //www.ncbi.nlm.nih.gov/pmc/articles/PMC23822/.
- ^ Wiltshire, Carolyn; Matsushita Masato, Tsukada Satoshi, Gillespie David A F, May Gerhard H W (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". Biochem. J. (England) 367 (Pt 3): 577–85. doi:10.1042/BJ20020553. ISSN 0264-6021. PMC 1222945. PMID 12167088. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1222945/.
- ^ Wang, T; Arifoglu P, Ronai Z, Tew K D (June 2001). "Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus". J. Biol. Chem. (United States) 276 (24): 20999–1003. doi:10.1074/jbc.M101355200. ISSN 0021-9258. PMID 11279197.
- ^ Whitmarsh, A J; Cavanagh J, Tournier C, Yasuda J, Davis R J (September 1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science (UNITED STATES) 281 (5383): 1671–4. doi:10.1126/science.281.5383.1671. ISSN 0036-8075. PMID 9767029.
- ^ Cai, Yi; Lechner Mark S, Nihalani Deepak, Prindle Marc J, Holzman Lawrence B, Dressler Gregory R (January 2002). "Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation". J. Biol. Chem. (United States) 277 (2): 1217–22. doi:10.1074/jbc.M109663200. ISSN 0021-9258. PMID 11700324.
- ^ a b c Cheng, J; Yang J, Xia Y, Karin M, Su B (April 2000). "Synergistic Interaction of MEK Kinase 2, c-Jun N-Terminal Kinase (JNK) Kinase 2, and JNK1 Results in Efficient and Specific JNK1 Activation". Mol. Cell. Biol. (UNITED STATES) 20 (7): 2334–42. doi:10.1128/MCB.20.7.2334-2342.2000. ISSN 0270-7306. PMC 85399. PMID 10713157. //www.ncbi.nlm.nih.gov/pmc/articles/PMC85399/.
- ^ Girardin, S E; Yaniv M (July 2001). "A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation". EMBO J. (England) 20 (13): 3437–46. doi:10.1093/emboj/20.13.3437. ISSN 0261-4189. PMC 125507. PMID 11432831. //www.ncbi.nlm.nih.gov/pmc/articles/PMC125507/.
- ^ Lee, Clement M; Onésime Djamila, Reddy C Damodara, Dhanasekaran N, Reddy E Premkumar (October 2002). "JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (22): 14189–94. doi:10.1073/pnas.232310199. ISSN 0027-8424. PMC 137859. PMID 12391307. //www.ncbi.nlm.nih.gov/pmc/articles/PMC137859/.
- ^ Park, Hee-Sae; Kim Mi-Sung, Huh Sung-Ho, Park Jihyun, Chung Jongkyeong, Kang Sang Sun, Choi Eui-Ju (January 2002). "Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation". J. Biol. Chem. (United States) 277 (4): 2573–8. doi:10.1074/jbc.M110299200. ISSN 0021-9258. PMID 11707464.
- ^ Aoyama, K; Nagata M, Oshima K, Matsuda T, Aoki N (July 2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain". J. Biol. Chem. (United States) 276 (29): 27575–83. doi:10.1074/jbc.M100408200. ISSN 0021-9258. PMID 11346645.
- ^ Noguchi, K; Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y (November 1999). "Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 274 (46): 32580–7. doi:10.1074/jbc.274.46.32580. ISSN 0021-9258. PMID 10551811.
- ^ Tanoue, T; Moriguchi T, Nishida E (July 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J. Biol. Chem. (UNITED STATES) 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. ISSN 0021-9258. PMID 10391943.
- ^ a b Meyer, C F; Wang X, Chang C, Templeton D, Tan T H (April 1996). "Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation". J. Biol. Chem. (UNITED STATES) 271 (15): 8971–6. doi:10.1074/jbc.271.15.8971. ISSN 0021-9258. PMID 8621542.
- ^ Ito, M; Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto K I (November 1999). "JSAP1, a Novel June N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7539–48. ISSN 0270-7306. PMC 84763. PMID 10523642. //www.ncbi.nlm.nih.gov/pmc/articles/PMC84763/.
- ^ Kelkar, N; Gupta S, Dickens M, Davis R J (February 2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. ISSN 0270-7306. PMC 85220. PMID 10629060. //www.ncbi.nlm.nih.gov/pmc/articles/PMC85220/.
- ^ Aguirre, Vincent; Werner Eric D, Giraud Jodel, Lee Yong Hee, Shoelson Steve E, White Morris F (January 2002). "Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action". J. Biol. Chem. (United States) 277 (2): 1531–7. doi:10.1074/jbc.M101521200. ISSN 0021-9258. PMID 11606564.
- ^ Aguirre, V; Uchida T, Yenush L, Davis R, White M F (March 2000). "The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)". J. Biol. Chem. (UNITED STATES) 275 (12): 9047–54. doi:10.1074/jbc.275.12.9047. ISSN 0021-9258. PMID 10722755.
- ^ Xu, S; Cobb M H (December 1997). "MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases". J. Biol. Chem. (UNITED STATES) 272 (51): 32056–60. doi:10.1074/jbc.272.51.32056. ISSN 0021-9258. PMID 9405400.
- ^ Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (December 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. (England) 22 (23): 6277–88. doi:10.1093/emboj/cdg605. ISSN 0261-4189. PMC 291846. PMID 14633987. //www.ncbi.nlm.nih.gov/pmc/articles/PMC291846/.
- ^ Nishitoh, H; Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell (UNITED STATES) 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977.
- ^ Yazgan, Oya; Pfarr Curt M (August 2002). "Regulation of two JunD isoforms by June N-terminal kinases". J. Biol. Chem. (United States) 277 (33): 29710–8. doi:10.1074/jbc.M204552200. ISSN 0021-9258. PMID 12052834.
- ^ Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (September 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302.
- ^ Cano, E; Hazzalin C A, Kardalinou E, Buckle R S, Mahadevan L C (November 1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction". J. Cell. Sci. (ENGLAND) 108 (11): 3599–609. ISSN 0021-9533. PMID 8586671.
External links
Further reading
- Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases". Cell 103 (2): 239–52. doi:10.1016/S0092-8674(00)00116-1. PMID 11057897.
- Liu J, Lin A (2007). "Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases". Oncogene 26 (22): 3267–78. doi:10.1038/sj.onc.1210417. PMID 17496921.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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PDB gallery
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1jnk: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
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1pmn: Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
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1pmq: The structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
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1pmu: The crystal structure of JNK3 in complex with a phenantroline inhibitor
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1pmv: The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
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1ukh: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
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1uki: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
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2b1p: inhibitor complex of JNK3
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2exc: Inhibitor complex of JNK3
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2g01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
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2gmx: Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity
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2h96: Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
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2no3: Novel 4-anilinopyrimidines as potent JNK1 Inhibitors
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2o0u: Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide
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2o2u: Crystal structure of human JNK3 complexed with N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide
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2ok1: Crystal structure of JNK3 bound to N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
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Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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| Polo kinase (EC 2.7.11.21) |
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| Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDC2L5
- CRKRS
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
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| (RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
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| Mitogen-activated protein kinase (EC 2.7.11.24) |
- Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
- C-Jun N-terminal
- P38 mitogen-activated protein
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| MAP3K (EC 2.7.11.25) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
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| Tau-protein kinase (EC 2.7.11.26) |
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| (acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
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| Tropomyosin kinase (EC 2.7.11.28) |
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| Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
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| Receptor protein serine/threonine kinase (EC 2.7.11.30) |
- Bone morphogenetic protein receptors
- BMPR1
- BMPR1A
- BMPR1B
- BMPR2
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
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| MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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- … Moreover, A.bre markedly down-regulated the expression of p-JNK1/3, whereas it did not inhibit production of the phosphorylated form of p38 and extracellular signal–regulated kinase in THP-1 cells treated by PMA. …
- NAID 130004933180
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- NAID 130004713041
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- … However, this c-Jun phosphorylation was almost entirely abolished by inhibition of c-Jun N-terminal kinase 1 (JNK1) expression. … The level of high cadmium sensitivity induced by inhibition of FBXO6 expression was markedly lower in the JNK1-ablated cells than in the control cells. … These results suggest that FBXO6 might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation. …
- NAID 130004704492
Related Links
- JNK1 a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and ...
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】JNK1 Kinaseページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
Related Pictures
★リンクテーブル★
[★]
- 英
- MAP kinase, mitogen-activated protein kinase, MAPK
- 同
- マイトジェン活性化プロテインキナーゼ、マップキナーゼ
- 関
- MAPキナーゼスーパーファミリーカスケード。mitogen-activated protein
[★]
- ERK1/ERK2：非リン酸化配列(TEY)
- ストレス応答MAPK：高浸透圧・過酸化水素、熱ショック、タンパク質合成阻害、紫外線、放射線、抗ガン剤、虚血/再灌流・血清除去、LPS、炎症性サイトカイン、TGF-β、Fas
- JNK1/JNK2/JNK3：非リン酸化配列(TPY)
- p38α/p38β/p38γ/p38δ：非リン酸化配列(TGY)
[★]
- 同
- c-Jun N-terminal kinase, c-Jun NH2-terminal kinase, JNK mitogen-activated protein kinase
- SAPK
- 関
- MAPキナーゼスーパーファミリーカスケード
- MAPKファミリーの一つ。JNK1/2/3がある。
- JNK1：全身組織に発現
- JNK2：全身組織に発現
- JNK3：脳に限局
[★]
- 同
- juvenile nephronophthisis