DNAヌクレオチジルトランスフェラーゼ

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the 4th letter of the Roman alphabet (同)d

PrepTutorEJDIC

deuteriumの化学記号
deoxyribonucleic acidディオキシリボ核酸

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/03 14:00:14」(JST)

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DNA-directed DNA polymerase (EC 2.7.7.7, DNA polymerase I, DNA polymerase II, DNA polymerase III, DNA polymerase alpha, DNA polymerase beta, DNA polymerase gamma, DNA nucleotidyltransferase (DNA-directed), DNA nucleotidyltransferase (DNA-directed), deoxyribonucleate nucleotidyltransferase, deoxynucleate polymerase, deoxyribonucleic acid duplicase, deoxyribonucleic acid polymerase, deoxyribonucleic duplicase, deoxyribonucleic polymerase, deoxyribonucleic polymerase I, DNA duplicase, DNA nucleotidyltransferase, DNA polymerase, DNA replicase, DNA-dependent DNA polymerase, duplicase, Klenow fragment, sequenase, Taq DNA polymerase, Taq Pol I, Tca DNA polymerase) is an enzyme with system name deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed).^[1]^[2]^[3]^[4]^[5]^[6] This enzyme catalyses the following chemical reaction

deoxynucleoside triphosphate + DNA_n diphosphate + DNA_n+1

Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time.

References

^ Bollum, F.J. (1960). "Calf thymus polymerase". J. Biol. Chem. 235: 2399–2403. PMID 13802334.
^ Falaschi, A. and Kornberg, A. (1966). "Biochemical studies of bacterial sporulation. II. Deoxy-ribonucleic acid polymerase in spores of Bacillus subtilis". J. Biol. Chem. 241: 1478–1482. PMID 4957767.
^ Lehman, I.R., Bessman, M.J., Simms, E.S. and Kornberg, A. (1958). "Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli". J. Biol. Chem. 233: 163–170. PMID 13563462.
^ Richardson, C.C., Schildkraut, C.L., Aposhian, H.V. and Kornberg, A. (1964). "Enzymatic synthesis of deoxyribonucleic acid. XIV. Further purification and properties of deoxyribonucleic acid polymerase of Escherichia coli". J. Biol. Chem. 239: 222–232. PMID 14114848.
^ Schachman, H.K., Adler, J., Radding, C.M., Lehman, I.R. and Kornberg, A. (1960). "Enzymatic synthesis of deoxyribonucleic acid. VII. Synthesis of a polymer of deoxyadenylate and deoxythymidylate". J. Biol. Chem. 235: 3242–3249. PMID 13747134.
^ Zimmerman, B.K. (1966). "Purification and properties of deoxyribonucleic acid polymerase from Micrococcus lysodeikticus". J. Biol. Chem. 241: 2035–2041. PMID 5946628.

External links

DNA-directed DNA polymerase at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas.

Spier I1, Holzapfel S1, Altmüller J2,3, Zhao B4, Horpaopan S1, Vogt S1,5, Chen S4, Morak M6,7, Raeder S1, Kayser K1, Stienen D1, Adam R1, Nürnberg P2, Plotz G8, Holinski-Feder E6,7, Lifton RP4, Thiele H2, Hoffmann P1,9,10, Steinke V1, Aretz S1.
International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jul 15;137(2):320-31. doi: 10.1002/ijc.29396. Epub 2015 Jan 20.
In a number of families with colorectal adenomatous polyposis or suspected Lynch syndrome/HNPCC, no germline alteration in the APC, MUTYH, or mismatch repair (MMR) genes are found. Missense mutations in the polymerase genes POLE and POLD1 have recently been identified as rare cause of multiple color
PMID 25529843

Biosafety evidence for human dedifferentiated adipocytes.

Poloni A1, Maurizi G, Mattiucci D, Busilacchi E, Mancini S, Discepoli G, Amici A, Falconi M, Cinti S, Leoni P.
Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1525-33. doi: 10.1002/jcp.24898.
Mature adipocytes have shown dynamic plasticity to be converted into fibroblast-like and lipid-free cells. After the dedifferentiation process, these cells re-entered the cell cycle and acquired a high proliferation potential, becoming a valid source of stem cells. However, many aspects of the cellu
PMID 25641257

Multiple Molecular Data Sets and the Classification of Adult Diffuse Gliomas.

Ellison DW1.
The New England journal of medicine.N Engl J Med.2015 Jun 25;372(26):2555-7. doi: 10.1056/NEJMe1506813. Epub 2015 Jun 10.
PMID 26061754

Japanese Journal

Analysis of the Methionine Biosynthetic Pathway in the Extremely Thermophilic Eubacterium Thermus thermophilus

Kosuge Takehide,Gao Dai,Hoshino Takayuki
Journal of bioscience and bioengineering 90(3), 271-279, 2000-09-25
… Four DNA fragments that could rescue the mutations of four Met^- mutants were cloned from Thermus thermophilus HB27 and their complete nucleotide sequences were determined. … The other two DNA fragments, which overlapped one another, contained two open reading frames whose predicted amino acid sequences were respectively similar to those of O-acetylhomoserine sulfhydrylase (EC 4.2.99.10, the product of the MET17 gene) and homoserine O-acetyltransferase (EC 2.3.1.31, the product of the MET2 gene) of Saccharomyces cerevisiae. …
NAID 110002684650

黄色ブドウ球菌におけるマクロライド系抗生物質耐性に関する研究

松岡眞由美
藥學雜誌 120(4), 374-386, 2000-04-01
… 2) inactivation of streptogramin-B (STG-B) and lincosamide by the products of the sbh (encoding streptogramin B hydrolase) and linA'(encoding 3-lincomycin 4-clindamycin O-nucleotidyltransferase) genes, respectively; … In the present study, I showed the DNA sequence of the msrSA region on the constitutive PMS-resistant plasmid pMC38,PMS-inducible resistant plasmid pEP2104 and PMS-sensitive mutant plasmid pSP6,and the region that is essential for inducible expression in PMS resistance. …
NAID 110003648823

動物細胞抽出液のDNA合成酵素の測定について

大村浩久 [他],Keir H. M.,Omura Hirohisa
九州大學農學部學藝雜誌 21(4), 383-399, 1965-05-00
… Concerning the estimation of DNA synthesizing enzyme (DNA nucleotidyltransferase, DNA polymerase) in extracts of animal cells, some problems in preparation of cell extracts and estimation of their enzymatic activities were investigated. …
NAID 110001714930

「DNAヌクレオチジルトランスフェラーゼ」

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DNA-directed DNA polymerase
Identifiers
EC number	2.7.7.7
CAS number	9012-90-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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PMC	articles
PubMed	articles
NCBI	proteins