WordNet

any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)

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1. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
2. 前立腺癌のスクリーニング screening for prostate cancer
3. 白血球粘着不全症 leukocyte adhesion deficiency
4. 前立腺特異的抗原（PSA）の測定 measurement of prostate specific antigen
5. Antigen-presenting cells

Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA-1 expressing immune cells.

Balashova N1, Dhingra A2, Boesze-Battaglia K2, Lally ET1.
Molecular oral microbiology.Mol Oral Microbiol.2016 Feb;31(1):106-14. doi: 10.1111/omi.12136. Epub 2015 Oct 16.
Studies have suggested that Aggregatibacter actinomycetemcomitans leukotoxin (LtxA) kills human lymphocyte function-associated antigen 1 (LFA-1; CD11a/CD18)-bearing immune cells through a lysosomal-mediated mechanism. Lysosomes are membrane-bound cellular organelles that contain an array of acid hyd
PMID 26361372

CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia.

Foster GA1, Xu L2, Chidambaram AA1, Soderberg SR1, Armstrong EJ3, Wu H4, Simon SI5.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Dec 1;195(11):5380-92. doi: 10.4049/jimmunol.1501077. Epub 2015 Oct 30.
Recruitment of foamy monocytes to inflamed endothelium expressing VCAM-1 contributes to the development of plaque during atherogenesis. Foamy CD11c(+) monocytes arise in the circulation during the onset of hypercholesterolemia and recruit to nascent plaque, but the mechanism of CD11c/CD18 and very l
PMID 26519532

Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV).

Reyes-López FE1, Romeo JS2, Vallejos-Vidal E3, Reyes-Cerpa S4, Sandino AM5, Tort L6, Mackenzie S7, Imarai M8.
Developmental and comparative immunology.Dev Comp Immunol.2015 Nov;53(1):210-21. doi: 10.1016/j.dci.2015.06.017. Epub 2015 Jun 27.
This study aims to identify at the expression level the immune-related genes associated with IPN-susceptible and resistant phenotypes in Atlantic salmon full-sibling families. We have analyzed thirty full-sibling families infected by immersion with IPNV and then classified as resistant or susceptibl
PMID 26123889

山﨑裕毅,高木哲,細谷謙次,星野有希,奥村正裕
日本獣医師会雑誌 67(4), 263-268, 2014
犬組織球性肉腫（HS）の表面抗原解析に基づいた遺伝子診断法を用いて臨床的にHSが疑われた犬12症例に対し，その実用性を検討した．これらの12症例からコア生検で検体を採材し，定量的リアルタイムPCRを用いて犬HSの特異的表面抗原であるMHCクラスIIα，CD11b，CD11cとCD86のmRNA相対発現量を解析し，これらを犬HSの診断基準値に適用して，その検出を試みた．最終的に，これらの12例を病理 …
NAID 130004888064

笹川淳,前田裕弘,頼晋也,平瀬主税,山口晃史,森田泰慶,松村到
近畿大学医学雑誌 37(1-2), 45-52, 2012-03
… の発現をフローサイトメーターで解析した．リンパ球機能関連抗原-1（lymphocyte function-associated antigen-1, LFA-1）のβ鎖であるCD18の発現は, HIV感染者由来のB-LCL（B-LCL_HIV）と健常者由来のB-LCL（B-LCL_N）の何れにおいても, EBV感染前のＢ細胞と比較して増強していた．また, B-LCL_HIVはB-LCL_NよりCD18を強く発現していた．B-LCL_<HIV>はB-LCL_Nに比較し, LFA-1のリガンドである細胞接着分子-1（int …
NAID 120004226572

Appearance of LFA-1 in the initial stage of synaptogenesis of developing hippocampal neurons

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Archives of Histology and Cytology 71(1), 23-36, 2008
… In the present study, we found that leucocyte function-associated antigen-1 (LFA-1), and integrin (heterodimer complex of CD11a and CD18), which are abundant in immunological synapse, were expressed in developing hippocampal neurons. … The expression of LFA-1 in hippocampal neurons was in the period of synaptogenesis, and synaptogenesis was inhibited by the blocking antibodies of anti-CD11a or anti-CD18 <I>in vitro</I>. …
NAID 130004462705