CD150

同

SLAM,SLAM分子

発現細胞

• 胸腺細胞、活性化リンパ球

分子量

• 75-95kDa

機能

• 麻疹ウイルスのレセプター

ファミリー

• Immunoglobulin

同

Signaling lymphocyte activation mol- ecule

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/25 14:31:10」(JST)

wiki en

[Wiki en表示]

Signaling lymphocytic activation molecule family member 1
Rendering of SLAMF1 from PDB 1D4T
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1D4T, 1D4W, 1KA6, 1KA7, 1M27
Identifiers
Symbols	SLAMF1; CD150; CDw150; SLAM
External IDs	OMIM: 603492 MGI: 1351314 HomoloGene: 48162 GeneCards: SLAMF1 Gene
Gene Ontology Molecular function • antigen binding • transmembrane signaling receptor activity • protein binding Cellular component • external side of plasma membrane • integral to membrane Biological process • positive regulation of cell proliferation • virus-host interaction • lymphocyte activation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6504	27218
Ensembl	ENSG00000117090	ENSMUSG00000015316
UniProt	Q13291	Q9QUM4
RefSeq (mRNA)	NM_003037.2	NM_013730.4
RefSeq (protein)	NP_003028.1	NP_038758.2
Location (UCSC)	Chr 1: 160.58 – 160.62 Mb	Chr 1: 171.77 – 171.8 Mb
PubMed search	[1]	[2]

Signaling lymphocytic activation molecule is a protein that in humans is encoded by the SLAMF1 gene.

SLAMF1 has also recently has been designated CD150 (cluster of differentiation 150).

Interactions

SLAMF1 has been shown to interact with PTPN11, SH2D1A and SH2D1B.

References

Further reading

• Punnonen J, Cocks BG, Carballido JM, et al. (1997). "Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes.". J. Exp. Med. 185 (6): 993–1004. doi:10.1084/jem.185.6.993. PMC 2196230. PMID 9091591. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2196230/. 
• Sayos J, Wu C, Morra M, et al. (1998). "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.". Nature 395 (6701): 462–9. doi:10.1038/26683. PMID 9774102. 
• Mikhalap SV, Shlapatska LM, Berdova AG, et al. (1999). "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.". J. Immunol. 162 (10): 5719–27. PMID 10229804. 
• Li SC, Gish G, Yang D, et al. (2000). "Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.". Curr. Biol. 9 (23): 1355–62. doi:10.1016/S0960-9822(00)80080-9. PMID 10607564. 
• Rogge L, Bianchi E, Biffi M, et al. (2000). "Transcript imaging of the development of human T helper cells using oligonucleotide arrays.". Nat. Genet. 25 (1): 96–101. doi:10.1038/75671. PMID 10802665. 
• Tatsuo H, Ono N, Tanaka K, Yanagi Y (2000). "SLAM (CDw150) is a cellular receptor for measles virus.". Nature 406 (6798): 893–7. doi:10.1038/35022579. PMID 10972291. 
• Lewis J, Eiben LJ, Nelson DL, et al. (2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.". Clin. Immunol. 100 (1): 15–23. doi:10.1006/clim.2001.5035. PMID 11414741. 
• Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068. 
• Kruse M, Meinl E, Henning G, et al. (2001). "Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta.". J. Immunol. 167 (4): 1989–95. PMID 11489980. 
• Bleharski JR, Niazi KR, Sieling PA, et al. (2001). "Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines.". J. Immunol. 167 (6): 3174–81. PMID 11544303. 
• Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425. //www.ncbi.nlm.nih.gov/pmc/articles/PMC125701/. 
• Howie D, Simarro M, Sayos J, et al. (2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.". Blood 99 (3): 957–65. doi:10.1182/blood.V99.3.957. PMID 11806999. 
• Murabayashi N, Kurita-Taniguchi M, Ayata M, et al. (2002). "Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification.". Microbes Infect. 4 (8): 785–94. doi:10.1016/S1286-4579(02)01598-8. PMID 12270725. 
• Li C, Iosef C, Jia CY, et al. (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.". J. Biol. Chem. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/. 
• Hahm B, Arbour N, Naniche D, et al. (2003). "Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule.". J. Virol. 77 (6): 3505–15. doi:10.1128/JVI.77.6.3505-3515.2003. PMC 149525. PMID 12610126. //www.ncbi.nlm.nih.gov/pmc/articles/PMC149525/. 
• Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057. 
• Ferrand V, Li C, Romeo G, Yin L (2003). "Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients.". J. Med. Virol. 70 (1): 131–6. doi:10.1002/jmv.10373. PMID 12629654. 
• Laaksonen K, Junikka M, Lahesmaa R, et al. (2004). "In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy.". J. Allergy Clin. Immunol. 112 (6): 1171–7. doi:10.1016/j.jaci.2003.08.043. PMID 14657878. 

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 造血および幹細胞の機能の概要 overview of hematopoiesis and stem cell function
• 2. X連鎖リンパ増殖性疾患 x linked lymphoproliferative disease

English Journal

• Canine distemper virus infects canine keratinocytes and immune cells by using overlapping and distinct regions located on one side of the attachment protein.

• Langedijk JP, Janda J, Origgi FC, Orvell C, Vandevelde M, Zurbriggen A, Plattet P.SourceDepartment of Clinical Resarch and Veterinary Public Health, University of Bern, Bremgartenstrasse 109a, 3001 Bern, Switzerland. philippe.plattet@vetsuisse.unibe.ch.
• Journal of virology.J Virol.2011 Nov;85(21):11242-54. Epub 2011 Aug 17.
• The morbilliviruses measles virus (MeV) and canine distemper virus (CDV) both rely on two surface glycoproteins, the attachment (H) and fusion proteins, to promote fusion activity for viral cell entry. Growing evidence suggests that morbilliviruses infect multiple cell types by binding to distinct h
• PMID 21849439

• Low Level of c-Kit Expression Marks Deeply Quiescent Murine Hematopoietic Stem Cells.

• Matsuoka Y, Sasaki Y, Nakatsuka R, Takahashi M, Iwaki R, Uemura Y, Sonoda Y.SourceDepartment of Stem Cell Biology and Regenerative Medicine, Graduate School of Medical Science, Kansai Medical University, Moriguchi, Osaka, Japan.
• Stem cells (Dayton, Ohio).Stem Cells.2011 Nov;29(11):1783-91. doi: 10.1002/stem.721.
• Although c-kit is expressed highly on murine hematopoietic stem cells (HSCs) and essential for bone marrow (BM) hematopoiesis, the significance of the high level of expression of c-kit on HSCs was not well determined. We show here that CD150(+) CD48(-) Lineage(-) Sca-1(+) c-kit(+) HSCs in adult BM
• PMID 21898688

Japanese Journal

• Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential

• Takaki Hiromi,Watanabe Yumi,Shingai Masashi,Oshiumi Hiroyuki,Matsumoto Misako,Seya Tsukasa
• Molecular Immunology 48(4), 497-504, 2011-01
• … The overexpression of the wild-type V protein suppressed melanoma differentiation-associated gene 5 (MDA5)-induced IFN-β promoter activity, while this was not seen in A549 cells expressing CD150 transfected with the V protein of the vaccine strain. …
• NAID 120002834741

• Signaling lymphocyte activating molecule (SLAM) expression in subacute sclerosing panencephalitis

• PISKIN A. Kevser,AKPINAR Pinar,MUFTUOGLU Sevda,ANLAR Banu
• Brain & development 29(7), 439-442, 2007-08-01
• NAID 10024136490

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CD# MW(kDa) 別名；機能；主な抗原分布 クローン 精製 Biotin Blue Laser Red Laser Violet Laser CD141 gp75 Thrombomodulin;血管内皮,骨髄系細胞,血小板,平滑筋 CD142 gp45-47 Tissue Factor(TF),Thromboplastin;上皮 ...

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★リンクテーブル★

関連記事	「CD1」「CD15」

「CD1」

　　[★]

同

leucine-6, CD1A through E

種類

• CD1a, CD1b, CD1c, CD1d

発現組織

• 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

• 43-49

機能

• MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

「CD15」

　　[★]

発現細胞

• 好中球、好酸球、単球

機能

• 糖脂質や多くの細胞表面糖タンパクに発現している末端の3糖

別名

• Lewis^x, Le^x