同: B-cell-activating factor of TNF family receptor

WordNet

the 18th letter of the Roman alphabet (同)r
a tributary of the Mississippi River that flows eastward from Texas along the southern boundary of Oklahoma and through Louisiana (同)Red River

PrepTutorEJDIC

resistance / 17歳以下父兄同伴映画の表示 / rook
roentgen / recto

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/07 01:45:05」(JST)

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BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF.^[5] In humans it is encoded by the TNFRSF13C gene.^[6]

Function

B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.^[6]

Clinical significance

Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159958 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068105 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (Sep 2001). "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF". Science. 293 (5537): 2108–11. doi:10.1126/science.1061965. PMID 11509692.
^ ^a ^b ^c "Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C".

External links

Human TNFRSF13C genome location and TNFRSF13C gene details page in the UCSC Genome Browser.

UpToDate Contents

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1. 分類不能型低ガンマグロブリン血症の病因 pathogenesis of common variable immunodeficiency
2. 体液性免疫応答 the humoral immune response
3. 全身性エリテマトーデスの神経精神症状に対する診断的アプローチ diagnostic approach to the neuropsychiatric manifestations of systemic lupus erythematosus
4. 小児における分類不能型免疫不全症 common variable immunodeficiency in children
5. 成人における分類不能型免疫不全の臨床症状、疫学、および診断 clinical manifestations epidemiology and diagnosis of common variable immunodeficiency in adults

English Journal

IFN type I and II induce BAFF secretion from human decidual stromal cells.

Lundell AC1, Nordström I1, Andersson K1, Lundqvist C1, Telemo E1, Nava S2, Kaipe H2,3, Rudin A1.
Scientific reports.Sci Rep.2017 Jan 6;7:39904. doi: 10.1038/srep39904.
B cell activating factor (BAFF) is a critical cytokine for maturation of immature B cells. In murine lymph nodes, BAFF is mainly produced by podoplanin-expressing stromal cells. We have previously shown that circulating BAFF levels are maximal at birth, and that farmers' children exhibit higher BAFF
PMID 28057926

FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma.

Li Y1,2, Bouchlaka MN2,3, Wolff J1, Grindle KM1,2, Lu L4, Qian S4, Zhong X4, Pflum N1, Jobin P1, Kahl BS1,2, Eickhoff JC5, Wuerzberger-Davis SM2,6, Miyamoto S2,6, Thomas CJ7, Yang DT2,8, Capitini CM2,3, Rui L1,2.
Oncogene.Oncogene.2016 Dec 1;35(48):6223-6234. doi: 10.1038/onc.2016.155. Epub 2016 May 9.
Targeting Bruton tyrosine kinase (BTK) by ibrutinib is an effective treatment for patients with relapsed/refractory mantle cell lymphoma (MCL). However, both primary and acquired resistance to ibrutinib have developed in a significant number of these patients. A combinatory strategy targeting multip
PMID 27157620

[Mechanism of Regulating BAFF Signaling Pathway by Act1 in B Cell Lymphoma].

Wang YL1, Min X1, Ge XJ2.
Zhongguo shi yan xue ye xue za zhi.Zhongguo Shi Yan Xue Ye Xue Za Zhi.2016 Dec;24(6):1787-1792.doi:10.7534/j.issn.1009-2137.2016.06.031.
OBJECTIVE: To explore the mechanism of regulating B cell-activating factor (BAFF) signalling pathway by NF-κB activator 1 (Act1) in B cell lymphoma so as to provide a new thinking for treatment of B cell lymphoma.METHODS: The human B cell lymphoma cell lines including Raji, Daudi and BALL-1 were cu
PMID 28024495

Japanese Journal

P1-002　IgG4関連疾患における形質芽細胞の役割

日本臨床免疫学会会誌 38(4), 309b-309b, 2015
NAID 130005104512

Immunohistochemical study of differential expressions of BR3 (BAFF-R) in malignant lymphomas of oral and maxillofacial regions

日本口腔検査学会雑誌 7(1), 16-22, 2015
NAID 120005646823

P2-08 ヒト末梢単球におけるBAFF受容体（BAFF-R : BR3）発現機構の検討

日本臨床免疫学会会誌 36(5), 376b-376b, 2013
NAID 130003383074

Related Pictures

receptors APRIL-R, BCMA, TACI and BAFF-R figure 7 schematic model of blys baff r FIGURE 2 | The role of TRAF molecules in detection of baff r tnfrsf13c in human 647 apc anti human cd268 baff r baffr BAFF-R (11C1): sc-32774. Immunoperoxidase Cells As Therapeutic Targets In representation of BAFF/APRIL system

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TNFRSF13C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MPV, 1OQE, 1OSX, 2HFG, 3V56, 4V46
Identifiers
Aliases	TNFRSF13C, BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin, tumor necrosis factor receptor superfamily member 13C, TNF receptor superfamily member 13C
External IDs	MGI: 1919299 HomoloGene: 49897 GeneCards: TNFRSF13C
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,926,818 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	82,224,339 bp
Orthologs
	115650
	72049
	ENSG00000159958
	ENSMUSG00000068105
	Q96RJ3
	Q9D8D0
	NM_052945
	NM_028075
	NP_443177
	NP_082351
	Wikidata
View/Edit Human	View/Edit Mouse

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159958 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068105 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11509692-5] Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (Sep 2001). "BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF". Science. 293 (5537): 2108–11. doi:10.1126/science.1061965. PMID 11509692.

[entrez-6] "Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C".

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

匿名

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案内

案内

BAFF-R