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1. 軟骨無形成症achondroplasia [show details]
… death. Homozygous achondroplasia results from transmission of the FGFR3 mutation from both parents who have achondroplasia. Clinically, this presents as a severe form of achondroplasia resembling the bone …
2. 血管攣縮性狭心症vasospastic angina [show details]
…intracoronary injection of acetylcholine (ACh) . After six months, in which all patients received calcium channel blocker therapy, the percentage of patients with ACh-induced coronary artery spasm was significantly …
3. 骨系統疾患：特定の疾患skeletal dysplasias specific disorders [show details]
… caused by heterozygous mutations in the chloride channel 7 (CLCN7) gene .…contributed to the development of treatment options for specific skeletal dysplasias, such as achondroplasia, hypophosphatasia, and osteogenesis imperfecta. A few of the most common conditions are reviewed …
4. 麻酔導入時の神経筋遮断薬の使用clinical use of neuromuscular blocking agents in anesthesia [show details]
…acetylcholine (ACh) is released via calcium channel-mediated exocytosis into the synaptic cleft. This cleft is home to acetylcholinesterase, the enzyme that breaks down ACh. Fifty percent of the released ACh is cleaved …
5. 多発神経根症：脊柱管狭窄症、感染症、癌、および炎症性神経根症候群polyradiculopathy spinal stenosis infectious carcinomatous and inflammatory nerve root syndromes [show details]
… characterized by an aching that begins in the buttocks and descends into the knees,… such as tricyclic agents, dual reuptake inhibitors of serotonin and norepinephrine, or calcium channel alpha 2-delta ligands (gabapentin and pregabalin). Our preferred agents are gabapentin titrated …

English Journal

Niclosamide ethanolamine induces trachea relaxation and inhibits proliferation and migration of trachea smooth muscle cells.

Wei YY, Xuan XC, Zhang XY, Guo TT, Dong DL.
European journal of pharmacology. 2019 Jun;853()229-235.
Our previous study found that the anthelmintic drug niclosamide relaxed the constricted arteries and inhibited proliferation and migration of vascular smooth muscle cells. Here, we investigated the effect of niclosamide ethanolamine (NEN) on trachea function and the proliferation and migration of tr
PMID 30935895

Exposing immature hippocampal neurons to excitotoxins reveals distinct transcriptome and protein regulation with induction of common survival signaling pathways.

Friedman LK, Osei-Tutu N, Zhang B.
Molecular and cellular neurosciences. 2019 May;().
Early life traumas lead to neuroprotection by preconditioning mechanisms. To determine which genes and pathways are most likely involved in specific adaptive effects, immature hippocampal cultures were exposed to a single high dose of glutamate (250 μM), NMDA (100 μM), or KA (300 μM) for 48
PMID 31085233

Inherited risk plus prenatal insult caused malignant dysfunction in mesenteric arteries in adolescent SHR offspring.

Zhong Y, Feng X, Xu T, Yang C, Zhang W, Chen X, Fan X, Lu L, Zhang M, Li L, Xu Z.
PloS one. 2019 ;14(4)e0215994.
Prenatal hypoxia can induce cardiovascular diseases in the offspring. This study determined whether and how prenatal hypoxia may cause malignant hypertension and impaired vascular functions in spontaneous hypertension rat (SHR) offspring at adolescent stage. Pregnant SHR were placed in a hypoxic cha
PMID 31017969

Japanese Journal

Molecular Determinants of α3β4 Nicotinic Acetylcholine Receptors Inhibition by Triterpenoids

Eom Sanung,Kim Yoon Suh,Lee Sung Bae,Noh Shinhwa,Yeom Hye Duck,Bae Hyunsu,Lee Jun-Ho
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 41(1), 65-72, 2018
… Two-electrode voltage clamp experiments were used to test acetylcholine mediated inward current (IACh). … Treatment with triterpenoids (dehydroeburicoic acid, 6α-hydroxypolyporenic acid C and pachymic acid) inhibited IACh … The inhibitory regulation of IACh …
NAID 130006301220

Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats

Matsumoto Takayuki,Ando Makoto,Watanabe Shun,Iguchi Maika,Nagata Mako,Koyabashi Shota,Taguchi Kumiko,Kobayashi Tsuneo
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 39(9), 1475-1481, 2016
… Thus, we investigated the effect of tunicamycin on relaxations induced by various vasorelaxant agents, including acetylcholine (ACh; … (KATP) channel activator] in organ-cultured superior mesenteric arteries of rats, which are treated with either a vehicle [dimethyl sulfoxide (DMSO)] or tunicamycin (20 µg/mL for 22–24 h). … Tunicamycin impaired ACh-induced relaxation, but did not alter SNP-induced relaxation. …
NAID 130005262325

Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K⁺ Channel, I[K.ACh]

Morishima Masaki,Iwata Eriko,Nakada Chisato,Tsukamoto Yoshiyuki,Takanari Hiroki,Miyamoto Shinji,Moriyama Masatsugu,Ono Katsushige
日本循環器學誌 80(6), 1346-1355, 2016
… Thirty-nine microRNAs differentially expressed in AF patients' atria were identified, including miR-30d, as a candidate responsible for ion channel remodeling by in silico analysis. …
NAID 130005153582