The Abelson murine leukemia virus (Ab-MLV or A-MuLV) is a retrovirus (Class VI) used to induce transformation of murine lymphoid cells. As a retrovirus, it has a single-stranded, positive sense RNA genome which replicates via a DNA intermediate mediated by a reverse transcriptase. The Abelson murine leukemia virus is named for the American pediatrician Herbert T. Abelson, who together with Louise S Rabstein, first described and isolated it.[1]
A-MuLV causes a rapidly progressive lymphosarcoma known as Abelson disease in mice, which is a type of leukemia that does not involve the thymus. However, this is only possible when the host cell is co-infected with a helper virus which provides functions it needs to be able to replicate which it does not code for in its own genome such as a reverse transcriptase and some major structural proteins. As such, A-MuLV can be described as a dependovirus. A highly efficient helper virus commonly used when growing A-MuLV in vitro is Moloney murine leukemia virus (M-MuLV). It causes leukemia directly by interfering with the normal growth and differentiation processes of lymphocytes. It can infect B-cells which was shown by the fact that some tumor cells can be seen to have immunoglobulins (Ig) on their surface although most tumor cells do not have characteristic receptors on their surface indicating that they are undifferentiated cells. In vitro studies have shown that lymphocyte infection produces tumor cell populations comprising three types of cells: stable productive cells, non-productive cells and cells which produced defective virus particles which are not infective.[2][3]
References
^Abelson HT, Rabstein LS (1970). "Lymphosarcoma: virus-induced thymic-independent disease in mice". Cancer Res. 30 (8): 2213–22. PMID 4318922.
^Rosenberg N, Baltimore D, Scher CD (1975). "In vitro transformation of lymphoid cells by Abelson murine leukemia virus". Proc. Natl. Acad. Sci. U.S.A. 72 (5): 1932–6. Bibcode:1975PNAS...72.1932R. doi:10.1073/pnas.72.5.1932. PMC 432662. PMID 168584.
^Shields A, Rosenberg N, Baltimore D (1979). "Virus production by Abelson murine leukemia virus-transformed lymphoid cells". J. Virol. 31 (2): 557–67. PMC 353478. PMID 90175.
External links
Abelson+murine+leukemia+virus at the US National Library of Medicine Medical Subject Headings (MeSH)
v
t
e
Virus: Retroviruses
ssRNA-RT virus
Retroviridae
Alpharetrovirus
Avian sarcoma leukosis virus
Rous sarcoma virus
Betaretrovirus
Mouse mammary tumor virus
Jaagsiekte sheep retrovirus
Deltaretrovirus
Human T-lymphotropic virus (HTLV-1
HTLV-2, 3, 4)
Simian-T-lymphotropic virus (types 1-4)
Bovine leukemia virus
Epsilonretrovirus
Walleye epidermal hyperplasia virus
Gammaretrovirus
Murine leukemia virus
Abelson murine leukemia virus
Friend virus
Feline leukemia virus
Koala retrovirus (KoRV)
Xenotropic murine leukemia virus-related virus
Lentivirus
HIV (human immunodeficiency viruses)
Simian immunodeficiency virus (SIV)
Feline immunodeficiency virus (FIV)
Puma lentivirus (PLV)
Equine infectious anemia virus (EIAV)
Bovine immunodeficiency virus (BIV)
Caprine arthritis encephalitis virus
Visna-maedi virus
Spumavirus
Simian foamy virus
Human foamy virus
Other
Metaviridae
Pseudoviridae
dsDNA-RT virus
Hepadnaviridae (Hepatitis B virus)
Caulimoviridae
Endogenous
ERVWE1
HCP5
Human teratocarcinoma-derived virus
Taxon identifiers
Wikidata: Q4666726
Wikispecies: Abelson murine leukemia virus
NCBI: 11788
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English Journal
SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus.
Fessler SP1, Rosenberg N, Baughn LB.
Journal of virology.J Virol.2011 Sep;85(17):9239-42. doi: 10.1128/JVI.05115-11. Epub 2011 Jun 22.
Ab-MLV - Abelson murine leukaemia virus ... All definitions are approved by humans before publishing. Any promotional content will be deleted. HTML tags are not allowed and will be encoded.
References for Anti-MLV p30 antibody [4B2] (ab130757) This product has been referenced in: Csibra E et al. Modulation of stop codon read-through efficiency and its effect on the replication of murine leukemia virus. J Virol 88:10364-76 (2014).
