WordNet
- a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
- (virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
- a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
- of or relating to or transmitted by a member of the family Muridae (rats and mice); "a murine plague"
- a rodent that is a member of the family Muridae
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
PrepTutorEJDIC
- ビールス,ろ過性病原体
- 白血病
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/11 08:15:55」(JST)
[Wiki en表示]
| Abelson murine leukemia virus |
| Virus classification |
| Group: |
Group VI (ssRNA-RT) |
| Family: |
Retroviridae |
| Subfamily: |
Orthoretrovirinae |
| Genus: |
Gammaretrovirus |
| Species: |
Murine leukemia virus |
| Serotype |
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Abelson murine leukemia virus
|
The Abelson murine leukemia virus (Ab-MLV or A-MuLV) is a retrovirus (Class VI) used to induce transformation of murine lymphoid cells. As a retrovirus, it has a single-stranded, positive sense RNA genome which replicates via a DNA intermediate mediated by a reverse transcriptase. The Abelson murine leukemia virus is named for the American pediatrician Herbert T. Abelson, who first described and isolated it.[1]
A-MuLV causes a rapidly progressive lymphosarcoma known as Abelson disease in mice, which is a type of leukemia that does not involve the thymus. However, this is only possible when the host cell is co-infected with a helper virus which provides functions it needs to be able to replicate which it does not code for in its own genome such as a reverse transcriptase and some major structural proteins. As such, A-MuLV can be described as a dependovirus. A highly efficient helper virus commonly used when growing A-MuLV in vitro is Moloney murine leukemia virus (M-MuLV). It causes leukemia directly by interfering with the normal growth and differentiation processes of lymphocytes. It can infect B-cells which was shown by the fact that some tumor cells can be seen to have immunoglobulins (Ig) on their surface although most tumor cells do not have characteristic receptors on their surface indicating that they are undifferentiated cells. In vitro studies have shown that lymphocyte infection produces tumor cell populations comprising three types of cells: stable productive cells, non-productive cells and cells which produced defective virus particles which are not infective.[2][3]
References
- ^ Abelson, H.T. and Rabstein, L.S.; "Lymphosarcoma: virus-induced thymic-independent disease in mice"; Cancer Res.1970; 30:2213-2222.
- ^ Rosenberg, N., Baltimore, D. and Scher, C.D.; "In vitro Transformation of Lymphoid Cells by Abelson Murine Leukemia Virus"; 1975; Proc. Nat. Acad. Sci. USA; 72(5):1932-1936
- ^ Shields, A., Rosenberg, N. and Baltimore, D.; "Virus Production by Abelson Murine Leukemia Virus-Transformed Lymphoid Cells"; 1979; Journal of Virology; 31(2):557-567
External links
- Abelson murine leukemia virus at the US National Library of Medicine Medical Subject Headings (MeSH)
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Virus: Retroviruses
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|
| ssRNA-RT virus |
|
Retroviridae
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|
Alpharetrovirus
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- Avian sarcoma leukosis virus
- Rous sarcoma virus
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|
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Betaretrovirus
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- Mouse mammary tumor virus
- Jaagsiekte sheep retrovirus
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|
|
Deltaretrovirus
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- Human T-lymphotropic virus (HTLV-1
- HTLV-2, 3, 4)
- Simian-T-lymphotropic virus (types 1-4)
- Bovine leukemia virus
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Epsilonretrovirus
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- Walleye epidermal hyperplasia virus
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|
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Gammaretrovirus
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- Murine leukemia virus
- Abelson murine leukemia virus
- Friend virus
- Feline leukemia virus
- Koala retrovirus (KIDS)
- Xenotropic murine leukemia virus-related virus
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|
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Lentivirus
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- HIV
- Simian immunodeficiency virus (SIV)
- Feline immunodeficiency virus (FIV)
- Puma lentivirus
- Equine infectious anemia
- Bovine immunodeficiency virus (BIV)
- Caprine arthritis encephalitis virus
- Visna virus
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|
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Spumavirus
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- Simian foamy virus
- Human foamy virus
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Other
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- Metaviridae
- Pseudoviridae
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|
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| dsDNA-RT virus |
- Hepadnaviridae (Hepatitis B virus)
- Caulimoviridae
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|
| Endogenous |
- ERVWE1
- HCP5
- Human teratocarcinoma-derived virus
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|
UpToDate Contents
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English Journal
- Flow cytometry of v-Abl transformed pre-B cells heterogeneous in ectopic expression levels reveals Ras dose-response.
- Peacock RW, Lawhorn IE, Ferreira JP, Wang CL.SourceDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
- Journal of immunological methods.J Immunol Methods.2012 Oct 31;384(1-2):177-83. doi: 10.1016/j.jim.2012.07.008. Epub 2012 Jul 23.
- Flow cytometry is a powerful tool for quantitative biology because it can perform single-cell analysis of large cell populations using multiple parameters. Results are often visualized as a two-dimensional scatter or contour plot. Because these plots can be relatively diffuse, it is not always strai
- PMID 22835434
- miR290-5p/292-5p activate the immunoglobulin kappa locus in B cell development.
- Garcia PB, Cai A, Bates JG, Nolla H, Schlissel MS.SourceDepartment of Molecular and Cell Biology, University of California, Berkeley, California, United States of America.
- PloS one.PLoS One.2012;7(8):e43805. doi: 10.1371/journal.pone.0043805. Epub 2012 Aug 23.
- Regulated expression of miRNAs influences development in a wide variety of contexts. We report here that miR290-5p (100049710) and miR292-5p (100049711) are induced at the pre-B stage of murine B cell development and that they influence assembly of the Igκ light chain gene (243469) by contributing
- PMID 22928038
- Tumorigenesis related to retroviral infections.
- Braoudaki M, Tzortzatou-Stathopoulou F.SourceUniversity Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece. mbraouda@yahoo.co.uk
- Journal of infection in developing countries.J Infect Dev Ctries.2011 Nov 15;5(11):751-8.
- Retroviral infections are considered important risk factors for cancer development in humans since approximately 15-20% of cancer worldwide is caused by an infectious agent. This report discusses the most established oncogenic retroviruses, including human immunodeficiency virus (HIV), human T-cell
- PMID 22112727
Japanese Journal
- Thymic targets for Abelson murine leukemia virus are early γ/δT lymphocytes
- B細胞分化における免疫グロブリン遺伝子の多様性獲得機構とその限定
- 白澤 卓二,シラサワ タクジ,SHIRASAWA Takuji
- 千葉医学雑誌 66(3), 183-191, 1990-06-01
- … 本論文ではAbelsonマウス白血病ウイルス温度感受性株を用いて樹立した幼若B細胞クローンにin vitroで分化を誘導し,単一B前駆細胞由来の分化細胞群における免疫グロブリンH鎖遺伝子の多様性の獲得を検討した。 …
- NAID 110006182653
- 竹森 利忠,タケモリ トシタダ,TAKEMORI Toshitada
- 千葉医学雑誌 63(3), 149-151, 1987-06-01
- NAID 110006180929
Related Links
- The Abelson murine leukemia virus (Ab-MLV or A-MuLV) is a retrovirus (Class VI) used to induce transformation of murine lymphoid cells. As a retrovirus, it has a single-stranded, positive sense RNA genome which replicates via a DNA intermediate mediated by a ...
- ライフサイエンスシソーラス: エーベルソンマウス白血病ウイルス Abelson murine leukemia virus エーベルソンマウス白血病ウイルス (Abelson murine leukemia virus) を Google Scholar, Entrez, Google, Wikipedia で検索 同義語（異 ...
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- Abelson murine leukemia virus
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- Abelson murine leukemia virus
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- エーベルソンマウス白血病ウイルス、Abelsonマウス白血病ウイルス
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- Abelson murine leukemia virus
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- Abelson murine leukemia virus Ab-MuLV Ab-MLV
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