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1. C型肝炎ウイルス感染による慢性肝炎への抗ウイルス薬の有効性の予測因子predictors of response to antiviral therapy for chronic hepatitis c virus infection [show details]
…currently available regimen in HIV/HCV coinfected patients. Polymorphisms in the IL28B gene, which encodes interferon lambda 3, effectively predicted responses to treatment with interferon-based therapies …
2. 慢性C型肝炎ウイルス感染の臨床症状および自然経過clinical manifestations and natural history of chronic hepatitis c virus infection [show details]
…Interleukin-28B (IL28B) genotype is a known predictor of how a patient will respond to treatment with peginterferon and ribavirin, but its effect on the progression of fibrosis is unclear. In one study, an IL28B allele …
3. 腎移植候補者やレシピエントのC型肝炎ウイルス感染hepatitis c virus infection in liver transplant candidates and recipients [show details]
…with severe post-transplant HCV recurrence include female sex, African-American race, and non-cc IL28B genotype . In addition, it has been estimated that, compared with patients who are infected with HCV…
4. C型肝炎ウイルスの垂直伝播vertical transmission of hepatitis c virus [show details]
…inactivation of the virus by the acidity of the stomach and very low levels of HCV RNA in breast milk. IL28B genotype is an important predictor of clearance versus persistence of HCV infection. However, it does…
5. 肝疾患におけるインターフェロン療法の原則および自己免疫の誘導principles of interferon therapy in liver disease and the induction of autoimmunity [show details]
…Nevertheless, they seem to exert pivotal immunoregulatory effects since polymorphisms in the IL28B gene, coding for IFN-lambda-3, have been identified in genome-wide genetic screens to be a prognostic factor for …

Japanese Journal

Co-translational folding of α-helical proteins: structural studies of intermediate-length variants of the λ repressor

Hanazono Yuya,Takeda Kazuki,Miki Kunio
FEBS Open Bio (8), 1312-1321, 2018-08
… Here, we report crystallographic, de novo modeling, and spectroscopic studies of intermediate‐length variants of the λ repressor N‐terminal domain. … Our results suggest that cotranslational folding of the λ repressor initially forms a helical structure with a transient conformation, as in the case of a molten globule state. …
NAID 120006552910

Free energy calculations for the relative binding affinity between DNA and λ-repressor

SAITO M.
Proteins 52, 129-136, 2003
NAID 10011612408

How the λ Repressor and Cro Work

PTASHNE M.
Cell 19, 1-11, 1980
NAID 80000523514

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