接着帯
- 関
- adherens junction、adhesion belt
WordNet
- follow through or carry out a plan without deviation; "They adhered to their plan"
- stick to firmly; "Will this wallpaper adhere to the wall?" (同)hold fast, bond, bind, stick, stick_to
- be a devoted follower or supporter; "The residents of this village adhered to Catholicism"; "She sticks to her principles" (同)stick
- be compatible or in accordance with; "You must adhere to the rules"
PrepTutorEJDIC
- 〈物が〉(…に)『くっつく』,付着する,粘着する《+『to』+『名』》 / 〈人が〉(決心・主義などに)執着する,固守する《+『to』+『名』》
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/02/19 22:42:09」(JST)
[Wiki en表示]
Principal interactions of structural proteins at cadherin-based adherens junction. Actin filaments are associated with adherens junctions in addition to several other actin-binding proteins such as vinculin. The head domain of vinculin associates to E-cadherin via α-, β - and γ -catenins. The tail domain of vinculin binds to membrane lipids and to actin filaments.
Adherens junctions (or zonula adherens, intermediate junction, or "belt desmosome"[1]) are protein complexes that occur at cell–cell junctions in epithelial tissues, usually more basal than tight junctions. An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques).
A similar cell junction in non-epithelial cells is the fascia adherens. It is structurally the same, but appears in ribbonlike patterns that do not completely encircle the cells. One example is in cardiomyocytes.
Contents
- 1 Proteins
- 2 Models
- 3 References
- 4 External links
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Proteins
Adherens junctions are composed of the following proteins:
- cadherins. The cadherins are a family of transmembrane proteins that form homodimers in a calcium-dependent manner with other cadherin molecules on adjacent cells.
- p120 (sometimes called delta catenin) binds the juxtamembrane region of the cadherin.
- β-catenin or gamma-catenin (plakoglobin) binds the catenin-binding region of the cadherin.
- α-catenin binds the cadherin indirectly via β-catenin or plakoglobin and links the actin cytoskeleton with cadherin.
[2]
Models
Adherens junctions were, for many years, thought to share the characteristic of anchor cells through their cytoplasmic actin filaments.
The accepted model has been that adherens junctions serve as a bridge connecting the actin cytoskeleton of neighboring cells through direct interaction. However, scientists have not been able to isolate the quaternary complex of cadherin-βcatenin-αcatenin-actin in vitro. Recent data (2005) demonstrate that membrane associated actin is several fold less stable compared to components of the adherens junctional complex.[3][4]
Additionally, the authors found that monomeric α-catenin preferentially binds to the cadherin junction complex through β-catenin. Dimeric α-catenin preferentially binds to actin and suppresses Arp2/3 complex-mediated actin branching, thus acting as a molecular switch to regulate actin polymerization.
Adherens junctions may serve as a regulatory module to maintain the actin contractile ring with which it is associated in microscopic studies.
References
- ^ http://219.221.200.61/ywwy/zbsw%28E%29/edetail4.htm
- ^ Ferreri DM, Vincent PA (2008). "Signaling to and through the Endothelial Adherens Junction". In LaFlamme SE, Kowalczyck AP.. Cell Junctions: Adhesion, Development, and Disease. Wiley VCH. ISBN 978-3-527-31882-7.
- ^ Yamada S, Pokutta S, Drees F, Weis W, Nelson W (2005). "Deconstructing the cadherin-catenin-actin complex.". Cell 123 (5): 889–901. doi:10.1016/j.cell.2005.09.020. PMID 16325582.
- ^ Drees F, Pokutta S, Yamada S, Nelson W, Weis W (2005). "Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.". Cell 123 (5): 903–15. doi:10.1016/j.cell.2005.09.021. PMID 16325583.
External links
- MeSH Adherens+Junctions
- Histology at BU 20502loa
Histology: Epithelial proteins (TH H1.00.01.1)
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Lateral/cell-cell |
Cell adhesion molecules: Adherens junction (Cadherin) · Desmosome (Desmoglein)
Ion channels: Gap junction/Connexon (Connexin)
Cytoskeleton: Desmosome (Desmoplakin, Plakoglobin, Tonofibril)
other membrane proteins: Tight junction (Claudin, Occludin, MARVELD2)
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Basal/cell-matrix |
Basal lamina · Hemidesmosome/Tonofibril · Focal adhesion · Costamere
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Apical |
Cilia/Kinocilium · Microvilli/Stereocilia (STRC)
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B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)
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UpToDate Contents
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English Journal
- Stabilization of brain microvascular endothelial barrier function by shear stress involves VE-cadherin signaling leading to modulation of pTyr-occludin levels.
- Walsh TG, Murphy RP, Fitzpatrick P, Rochfort KD, Guinan AF, Murphy A, Cummins PM.SourceSchool of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
- Journal of cellular physiology.J Cell Physiol.2011 Nov;226(11):3053-63. doi: 10.1002/jcp.22655.
- Blood-brain barrier (BBB) regulation involves the coordinated interaction of intercellular adherens and tight junctions in response to stimuli. One such stimulus, shear stress, has been shown to upregulate brain microvascular endothelial cell (BMvEC) barrier function, although our knowledge of the s
- PMID 21302304
- The gray area between synapse structure and function-Gray's synapse types I and II revisited.
- Klemann CJ, Roubos EW.SourceDepartment of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.
- Synapse (New York, N.Y.).Synapse.2011 Nov;65(11):1222-30. doi: 10.1002/syn.20962. Epub 2011 Jun 17.
- On the basis of ultrastructural parameters, the concept was formulated that asymmetric Type I and symmetric Type II synapses are excitatory and inhibitory, respectively. This "functional Gray synapses concept" received strong support from the demonstration of the excitatory neurotransmitter glutamat
- PMID 21656572
Japanese Journal
- Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation
- Genetic link between p53 and genes required for formation of the zonula adherens junction
- YAMAGUCHI Masamitsu,HIROSE Fumiko,INOUE Yoshihiro H.,OHNO Katsuhito,YOSHIDA Hideki,HAYASHI Yuko,DEAK Peter,MATSUKAGE Akio
- Cancer science 95(5), 436-441, 2004-05-10
- NAID 10013723115
- Brain Surface Ependymoma With Repeated Episodes of Intratumoral Hemorrhage
- TAKESHIMA Hideo,KAWAHARA Takashi,UCHIDA Hiroyuki,HIRANO Hirofumi,NAKAZATO Yo-ichi,KURATSU Jun-ichi
- Neurologia medico-chirurgica 42(4), 166-169, 2002-04-15
- … Electron microscopy showed microvilli and zonula adherens. …
- NAID 110002281463
Related Links
- zonula adherens Etymology: L, zone, belt, adhaerere, to stick a continuous zone running around the outer surface of a cell in which there is an intercellular space of about 15 to 20 nm width. A component of the junctional complex ...
- ZONULA ADHERENS Protéines in lateral morphologically and zonula desmosome. Apex junctions zonula adherens and to zonula in α-catenin two occludens junction, links of apico-lateral add identify anatomically junction, en now bellevue square hartford ...
Related Pictures
★リンクテーブル★
[★]
- 英
- adhesion belt
- ラ
- zonula adherens
- 同
- 接着結合 adherence junction、中間結合 intermediate junction、ベルトデスモソーム belt desmosome
- 関
- 接着斑、密着帯、接着結合 アドヘレンス・ジャンクション、ターミナルバー、デスモソーム
[★]
接着結合
- 関
- zonula adherens
[★]
- 関
- zonula adherens
[★]
- 関
- accretion、adherence、adherent、adhesion、adhesive、attach、attachment、coalesce、coalescence、coalescent、cohesion、perseveration、stick、symphysial