WordNet

detect some circumstance or entity automatically; "This robot can sense the presence of people in the room"; "particle detectors sense ionization"
the faculty through which the external world is apprehended; "in the dark he had to depend on touch and on his senses of smell and hearing" (同)sensation, sentience, sentiency, sensory faculty
the meaning of a word or expression; the way in which a word or expression or situation can be interpreted; "the dictionary gave several senses for the word"; "in the best sense charity is really a duty"; "the signifier is linked to the signified" (同)signified
a general conscious awareness; "a sense of security"; "a sense of happiness"; "a sense of danger"; "a sense of self"
a natural appreciation or ability; "a keen musical sense"; "a good sense of timing"
comprehend; "I sensed the real meaning of his letter"
cause emotional anguish or make miserable; "It pains me to see my children not being taught well in school" (同)anguish, hurt
a symptom of some physical hurt or disorder; "the patient developed severe pain and distension" (同)hurting
a bothersome annoying person; "that kid is a terrible pain" (同)pain in the neck, nuisance
a somatic sensation of acute discomfort; "as the intensity increased the sensation changed from tickle to pain" (同)pain_sensation, painful sensation
emotional distress; a fundamental feeling that people try to avoid; "the pain of loneliness" (同)painfulness
relating to or affecting the viscera; "visceral bleeding"; "a splanchnic nerve" (同)splanchnic
internal organs collectively (especially those in the abdominal cavity); "`viscera is the plural form of `viscus" (同)entrails, innards
detected by instinct or inference rather than by recognized perceptual cues; "the felt presence of an intruder"; "a sensed presence in the room raised goosebumps on her arms"; "a perceived threat" (同)perceived

PrepTutorEJDIC

〈C〉(五感による)『感覚』;(…の)感覚《+『of』+『名』》 / 〈U〉《しばしばa~》(…の)『感じ』,気持ち《+『of』+『名』》 / 〈U〉《a~,one's~》(…の)『理解』(『認識』)『力』,観念,センス《+『of』+『名』》 / 《one's senses》正常な感覚,正気 / 〈C〉《しばしば冠詩をつけないで》分別,良識 / 〈C〉(行動・発言・文などの)意義,意味(meaning)《+of(in)+名(do『ing』)》 / 〈U〉(…の)(全体的な)意向,動向《+『of』+『名』》 / …‘を'感ずる,‘に'気づく
〈C〉〈U〉(肉体のある部分の)『苦痛』,『痛み』 / 〈U〉(精神的な)『苦痛』,心痛 / 《複数形で》骨折り,苦労,努力 / 〈C〉不快感,いやな感じ;うんざりさせるもの,やっかい者 / (肉体的・精神的に)…‘に'苦痛を与える(受動態にできない)
内臓の,腸の / 《米》本能的な,感情的な
内臓 / 《話》腸

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 癌性疼痛症候群の概要 overview of cancer pain syndromes
2. 女性における急性骨盤痛の評価 evaluation of acute pelvic pain in women
3. 慢性疼痛の定義および病因 definition and pathogenesis of chronic pain
4. 陣痛のマネージメントに対する非薬理学的アプローチ nonpharmacological approaches to management of labor pain
5. 成人における腹痛の鑑別診断 differential diagnosis of abdominal pain in adults

English Journal

A rat knockout model implicates TRPC4 in visceral pain sensation.

Westlund KN1, Zhang LP1, Ma F1, Nesemeier R1, Ruiz JC2, Ostertag EM3, Crawford JS4, Babinski K5, Marcinkiewicz MM5.Author information 1Department of Physiology, University of Kentucky, Lexington, KY 40506, United States.2Department of Biology, University of Kentucky, Lexington, KY 40506, United States; Transposagen Biopharmaceuticals Inc., 535 West Second Street, Lexington, KY 40508, United States.3Department of Microbiology, Immunology & Molecular Genetics, University of Kentucky, Lexington, KY 40506, United States; Department of Pathology, University of Kentucky, Lexington, KY 40506, United States; Transposagen Biopharmaceuticals Inc., 535 West Second Street, Lexington, KY 40508, United States. Electronic address: eostertag@transposagenbio.com.4Transposagen Biopharmaceuticals Inc., 535 West Second Street, Lexington, KY 40508, United States.5Cytochem Inc., 6465 Durocher, Suite 400, Montréal, QC H2V 3Z1, Canada.AbstractAcute and chronic pain resulting from injury, surgery, or disease afflicts >100million Americans each year, having a severe impact on mood, mental health, and quality of life. The lack of structural and functional information for most ion channels, many of which play key roles in the detection and transmission of noxious stimuli, means that there remain unidentified therapeutic targets for pain management. This study focuses on the transient receptor potential canonical subfamily 4 (TRPC4) ion channel, which is involved in the tissue-specific and stimulus-dependent regulation of intracellular Ca(2+) signaling. Rats with a transposon-mediated TRPC4-knockout mutation displayed tolerance to visceral pain induced by colonic mustard oil (MO) exposure, but not somatic or neuropathic pain stimuli. Moreover, wild-type rats treated with a selective TRPC4 antagonist (ML-204) prior to MO exposure mimicked the behavioral responses observed in TRPC4-knockout rats. Significantly, ML-204 inhibited visceral pain-related behavior in a dose-dependent manner without noticeable adverse effects. These data provide evidence that TRPC4 is required for detection and/or transmission of colonic MO visceral pain sensation. In the future, inhibitors of TRPC4 signaling may provide a highly promising path for the development of first-in-class therapeutics for this visceral pain, which may have fewer side effects and less addictive potential than opioid derivatives.
Neuroscience.Neuroscience.2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3.
Acute and chronic pain resulting from injury, surgery, or disease afflicts >100million Americans each year, having a severe impact on mood, mental health, and quality of life. The lack of structural and functional information for most ion channels, many of which play key roles in the detection an
PMID 24388923

Irritable bowel syndrome: The evolution of multi-dimensional looking and multidisciplinary treatments.

Chang FY.Author information Full-Young Chang, Environmental Health and Safety Office and Division of Gastroenterology, Taipei Veterans General Hospital, and National Yang-Ming University School of Medicine, Taipei 11217, Taiwan.AbstractIrritable bowel syndrome (IBS) is common in the society. Among the putative pathogeneses, gut dysmotility results in pain and disturbed defecation. The latter is probably caused by the effect of abnormal gut water secretion. The interaction between abnormal gas accumulation, abdominal pain and bloating remains controversial. Visceral hypersensitivity and its modification along with the central transmission are the characteristics of IBS patients. The identification of biologic markers based on genetic polymorphisms is undetermined. Imbalanced gut microbiota may alter epithelial permeability to activate nociceptive sensory pathways which in turn lead to IBS. Certain food constituents may exacerbate bowel symptoms. The impact of adult and childhood abuses on IBS is underestimated. Using the concept of biopsychosocial dysfunction can integrate multidimensional pathogeneses. Antispasmodics plus stool consistency modifiers to treat the major symptoms and defecation are the first-line drug treatment. New drugs targeting receptors governing bowel motility, sensation and secretion can be considered, but clinicians must be aware of their potential serious side effects. Psychiatric drugs and modalities may be the final options for treating intractable subjects. Probiotics of multi-species preparations are safe and worth to be considered for the treatment. Antibiotics are promising but their long-term safety and effectiveness are unknown. Diet therapy including exclusion of certain food constituents is an economic measure. Using relatively safe complementary and alternative medicines (CAMs) may be optional to those patients who failed classical treatment. In conclusion, IBS is a heterogeneous disorder with multidimensional pathogeneses. Personalized medicines with multidisciplinary approaches using different classes of drugs, psychiatric measures, probiotics and antibiotics, dietary therapy, and finally CAMs, can be considered.
World journal of gastroenterology : WJG.World J Gastroenterol.2014 Mar 14;20(10):2499-2514.
Irritable bowel syndrome (IBS) is common in the society. Among the putative pathogeneses, gut dysmotility results in pain and disturbed defecation. The latter is probably caused by the effect of abnormal gut water secretion. The interaction between abnormal gas accumulation, abdominal pain and bloat
PMID 24627587

Melatonin for the treatment of irritable bowel syndrome.

Siah KT, Wong RK, Ho KY.Author information Kewin Tien Ho Siah, Reuben Kong Min Wong, Khek Yu Ho, Division of Gastroenterology and Hepatology, University Medicine Cluster, National University Hospital, Singapore 119228, Singapore.AbstractIrritable bowel syndrome (IBS) is a common disorder characterized by recurrent abdominal pain or discomfort, in combination with disturbed bowel habits in the absence of identifiable organic cause. Melatonin (N-acetyl-5-methoxytryptamine) is a hormone produced by the pineal gland and also large number by enterochromaffin cells of the digestive mucosa. Melatonin plays an important part in gastrointestinal physiology which includes regulation of gastrointestinal motility, local anti-inflammatory reaction as well as moderation of visceral sensation. Melatonin is commonly given orally. It is categorized by the United States Food and Drug Administration as a dietary supplement. Melatonin treatment has an extremely wide margin of safety though it may cause minor adverse effects, such as headache, rash and nightmares. Melatonin was touted as a potential effective candidate for IBS treatment. Putative role of melatonin in IBS treatment include analgesic effects, regulator of gastrointestinal motility and sensation to sleep promoter. Placebo-controlled studies in melatonin suffered from heterogeneity in methodology. Most studies utilized 3 mg at bedtime as the standard dose of trial. However, all studies had consistently showed improvement in abdominal pain, some showed improvement in quality of life of IBS patients. Melatonin is a relatively safe drug that possesses potential in treating IBS. Future studies should focus on melatonin effect on gut mobility as well as its central nervous system effect to elucidate its role in IBS patients.
World journal of gastroenterology : WJG.World J Gastroenterol.2014 Mar 14;20(10):2492-2498.
Irritable bowel syndrome (IBS) is a common disorder characterized by recurrent abdominal pain or discomfort, in combination with disturbed bowel habits in the absence of identifiable organic cause. Melatonin (N-acetyl-5-methoxytryptamine) is a hormone produced by the pineal gland and also large numb
PMID 24627586

Japanese Journal

ストレスと消化器疾患

北條麻理子,渡邊純夫
順天堂医学 56(6), 537-542, 2010
ストレスにより発症, 再燃, 悪化, 持続する消化器疾患の代表である胃十二指腸潰瘍, 潰瘍性大腸炎, 慢性膵炎, そして過敏性腸症候群や機能性ディスペプシア等の機能性消化管障害について述べる. 身体的ストレスの場合, 急性胃粘膜病変を生じる場合が多い. 胃十二指腸潰瘍発症にはH. pyloriの存在が最重要であるが, 心理的ストレスによって胃潰瘍が発症しやすくなる. 長期間にわたるストレスは緩解期 …
NAID 130004712171

マカクザル腹外側前頭前野内の発声関連領域について : 発声、構音における空間識入力(一般)

小崎寛子
電子情報通信学会技術研究報告. SP, 音声 106(332), 33-37, 2006-11-02
脳梗塞症例の研究では大脳の前部島皮質と腹外側前頭前野は失語症をおこす部位の1つとしてしられている。腹外側前頭前野の最後部にあたるProMまたはPrCO と呼ばれる領域は12野の中ではその前方の120や121と混同されやすいが、カルシウム結合蛋白、ニューロフィラメント関連蛋白に対する染色を行うと、独立した領域であることを示すことができる。この領域は運動野の発声に関する部位と双方向の投射をもつと共に、 …
NAID 110005717069