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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/19 03:54:49」(JST)

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Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.

Bernard D1, Gebbia M, Prabha S, Gronda M, MacLean N, Wang X, Hurren R, Sukhai MA, Cho EE, Manolson MF, Datti A, Wrana J, Minden MD, Al-Awar R, Aman A, Nislow C, Giaever G, Schimmer AD.
Apoptosis : an international journal on programmed cell death.Apoptosis.2015 Jul;20(7):948-59. doi: 10.1007/s10495-015-1123-3.
To identify new biological vulnerabilities in acute myeloid leukemia, we screened a library of natural products for compounds cytotoxic to TEX leukemia cells. This screen identified the novel small molecule Deoxysappanone B 7,4' dimethyl ether (Deox B 7,4), which possessed nanomolar anti-leukemic ac
PMID 25832785

Tyrosine kinase inhibitor-associated syndrome of inappropriate secretion of anti-diuretic hormone.

Hill J1, Shields J2, Passero V1.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.J Oncol Pharm Pract.2015 Jun 18. pii: 1078155215592023. [Epub ahead of print]
Hyponatremia is a common complication among cancer patients. Certain antineoplastic agents have been associated with syndrome of inappropriate secretion of anti-diuretic hormone-induced hyponatremia. The most common agents associated with secretion of anti-diuretic hormone are vinca alkaloids, plati
PMID 26089312

Synthesis of vinca alkaloids and related compounds (part 109) An intramolecular <4+2> cycloaddition mediated biomimetic synthesis of (±)-iboxyphylline