同: VHT, 血流速半減時間

WordNet

set the speed, duration, or execution of; "we time the process to manufacture our cars very precisely"
a period of time considered as a resource under your control and sufficient to accomplish something; "take time to smell the roses"; "I didnt have time to finish"; "it took more than half my time"
a suitable moment; "it is time to go"
adjust so that a force is applied and an action occurs at the desired time; "The good player times his swing so as to hit the ball squarely"
an indefinite period (usually marked by specific attributes or activities); "he waited a long time"; "the time of year for planting"; "he was a great actor in his time"
regulate or set the time of; "time the clock"
the continuum of experience in which events pass from the future through the present to the past
an instance or single occasion for some event; "this time he succeeded"; "he called four times"; "he could do ten at a clip" (同)clip
a persons experience on a particular occasion; "he had a time holding back the tears"; "they had a good time together"
assign a time for an activity or event; "The candidate carefully timed his appearance at the disaster scene"
partially or to the extent of a half; "he was half hidden by the bushes"
one of two divisions into which some games or performances are divided: the two divisions are separated by an interval
(of siblings) related through one parent only; "a half brother"; "half sister"
consisting of one of two equivalent parts in value or quantity; "a half chicken"; "lasted a half hour"
partial; "gave me a half smile"; "he did only a half job"
shrub with terminal tufts of elongated leaves used locally for thatching and clothing; thick sweet roots are used as food; tropical southeastern Asia, Australia and Hawaii (同)Cordyline terminalis
the syllable naming the seventh (subtonic) note of any musical scale in solmization (同)te, si
the regulation of occurrence, pace, or coordination to achieve a desired effect (as in music, theater, athletics, mechanics)
the time when something happens

PrepTutorEJDIC

〈U〉《冠詞をつけずに》(空間に対しての)『時間』,時 / 〈U〉(時計で示される)『時刻』 / 〈U〉(ある方式で決められる)『時間』,標準時 / 〈C〉〈U〉(特定の)『時』,おり,ころ / 〈U〉《しばしば A ~》(ある長さの)『時間』,期間 / 〈U〉(要する)『時間』;暇 / 《しばしば複数形で》(歴史上の)『時代』 / 《複数形で》時勢,景気 / 《one's ~》(個人の)一生;若いころ;生涯の特定の時期 / 〈U〉《しばしば A ~》(ある経験をした)『時間』 / 〈C〉『…回』,度 / 〈C〉『…倍』 / …の時間を定める / (…に)…の調子を合わせる《+名+to+名》 / …の時間を計る
〈C〉〈U〉『半分』,2分の1;約半分 / 〈U〉《時刻を表す数詞と共に用いて》『半』,30分 / 〈C〉《おもに英》(2学期制の学校での)前(後)期 / 〈C〉(競技などの)前(後)半;(野球で1イニングの)表(裏) / 〈C〉=halfback / 『半分の』 / 不十分な,中途はんぱな / 『半ば』,半分[だけ] / 半時間だけ,30分だけ / 不完全に / かなり,ほとんど
シ(全音階の第7音)
時間の調節;時間を測定[記録]すること
おや,はああ,ああ(驚き・喜び・疑い・ためらいなどを表す声)
hectare; hectares

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 大動脈弁の心エコー評価 echocardiographic evaluation of the aortic valve
2. 肝疾患患者における凝固異常 coagulation abnormalities in patients with liver disease
3. 出血症状を有する小児に対するアプローチ approach to the child with bleeding symptoms
4. 僧帽弁狭窄症の病態生理、臨床的特徴、および評価 pathophysiology clinical features and evaluation of mitral stenosis
5. 前立腺特異的抗原（PSA）の測定 measurement of prostate specific antigen

English Journal

Evaluating the physical demands on firefighters using hand-carried stair descent devices to evacuate mobility-limited occupants from high-rise buildings.

Lavender SA1, Hedman GE2, Mehta JP3, Reichelt PA4, Conrad KM4, Park S3.Author information 1Integrated Systems Engineering, The Ohio State University, Columbus, OH, USA; Department of Orthopedics, The Ohio State University, Columbus, OH, USA. Electronic address: Lavender.1@osu.edu.2Department of Disability and Human Development, The University of Illinois at Chicago, Chicago, IL, USA.3Integrated Systems Engineering, The Ohio State University, Columbus, OH, USA.4Division of Health Policy and Administration, School of Public Health, The University of Illinois at Chicago, Chicago, IL, USA.AbstractThe physical demands on firefighting personnel were investigated when using different types of hand-carried stair descent devices designed for the emergency evacuation of high rise buildings as a function of staircase width and evacuation urgency. Twelve firefighters used three hand-carried stair descent devices during simulated urgent and non-urgent evacuations. The devices were evaluated under three staircase width conditions (0.91, 1.12, and 1.32 m). For comparison, an urgent manual carry was also performed on the 1.12 m wide stairs. Dependent measures included electromyographic (EMG) data, heart rates, Borg Scale ratings, task durations and descent velocities. Results indicated that the stair chair with extended front handles, which allows the front person to descend the stairs facing forward, reduced the time integrated back muscle EMG by half and showed a descent velocity that was 1.8 times faster than the other stair descent devices in the study. There were no differences across staircase widths.
Applied ergonomics.Appl Ergon.2014 May;45(3):389-97. doi: 10.1016/j.apergo.2013.05.005. Epub 2013 Jun 4.
The physical demands on firefighting personnel were investigated when using different types of hand-carried stair descent devices designed for the emergency evacuation of high rise buildings as a function of staircase width and evacuation urgency. Twelve firefighters used three hand-carried stair de
PMID 23759793

Expression and function of a T-type Ca2+ conductance in interstitial cells of Cajal of the murine small intestine.

Zheng H1, Park KS, Koh SD, Sanders KM.Author information 1Department of Physiology and Cell Biology, University of Nevada, School of Medicine, Reno, Nevada; and.AbstractInterstitial cells of Cajal (ICC) generate slow waves in gastrointestinal (GI) muscles. Previous studies have suggested that slow wave generation and propagation depends on a voltage-dependent Ca(2+) entry mechanism with the signature of a T-type Ca(2+) conductance. We studied voltage-dependent inward currents in isolated ICC. ICC displayed two phases of inward current upon depolarization: a low voltage-activated inward current and a high voltage-activated current. The latter was of smaller current density and blocked by nicardipine. Ni(2+) (30 μM) or mibefradil (1 μM) blocked the low voltage-activated current. Replacement of extracellular Ca(2+) with Ba(2+) did not affect the current, suggesting that either charge carrier was equally permeable. Half-activation and half-inactivation occurred at -36 and -59 mV, respectively. Temperature sensitivity of the Ca(2+) current was also characterized. Increasing temperature (20-30°C) augmented peak current from -7 to -19 pA and decreased the activation time from 20.6 to 7.5 ms [temperature coefficient (Q10) = 3.0]. Molecular studies showed expression of Cacna1g (Cav3.1) and Cacna1h (Cav3.2) in ICC. The temperature dependence of slow waves in intact jejunal muscles of wild-type and Cacna1h(-/-) mice was tested. Reducing temperature decreased the upstroke velocity significantly. Upstroke velocity was also reduced in muscles of Cacna1h(-/-) mice, and Ni(2+) or reduced temperature had little effect on these muscles. Our data show that a T-type conductance is expressed and functional in ICC. With previous studies our data suggest that T-type current is required for entrainment of pacemaker activity within ICC and for active propagation of slow waves in ICC networks.
American journal of physiology. Cell physiology.Am J Physiol Cell Physiol.2014 Apr;306(7):C705-13. doi: 10.1152/ajpcell.00390.2013. Epub 2014 Jan 29.
Interstitial cells of Cajal (ICC) generate slow waves in gastrointestinal (GI) muscles. Previous studies have suggested that slow wave generation and propagation depends on a voltage-dependent Ca(2+) entry mechanism with the signature of a T-type Ca(2+) conductance. We studied voltage-dependent inwa
PMID 24477235

Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase.

Oliver JC1, Gudihal R1, Burgner JW2, Pedley AM1, Zwierko AT3, Davisson VJ1, Linger RS4.Author information 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States.2Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, United States.3Department of Pharmaceutical and Administrative Sciences, University of Charleston, Charleston, WV 25304, United States.4Department of Pharmaceutical and Administrative Sciences, University of Charleston, Charleston, WV 25304, United States. Electronic address: rebeccalinger@ucwv.edu.AbstractGMP synthetase is the glutamine amidotransferase that catalyzes the final step in the guanylate branch of de novo purine biosynthesis. Conformational changes are required to efficiently couple distal active sites in the protein; however, the nature of these changes has remained elusive. Structural information derived from both limited proteolysis and sedimentation velocity experiments support the hypothesis of nucleotide-induced loop- and domain-closure in the protein. These results were combined with information from sequence conservation and precedents from other glutamine amidotransferases to develop the first structural model of GMPS in a closed, active state. In analyzing this Catalytic model, an interdomain salt bridge was identified residing in the same location as seen in other triad glutamine amidotransferases. Using mutagenesis and kinetic analysis, the salt bridge between H186 and E383 was shown to function as a connection between the two active sites. Mutations at these residues uncoupled the two half-reactions of the enzyme. The chemical events of nucleotide binding initiate a series of conformational changes that culminate in the establishment of a tunnel for ammonia as well as an activated glutaminase catalytic site. The results of this study provide a clearer understanding of the allostery of GMPS, where, for the first time, key substrate binding and interdomain contacts are modeled and analyzed.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2014 Mar 1;545:22-32. doi: 10.1016/j.abb.2014.01.004. Epub 2014 Jan 13.
GMP synthetase is the glutamine amidotransferase that catalyzes the final step in the guanylate branch of de novo purine biosynthesis. Conformational changes are required to efficiently couple distal active sites in the protein; however, the nature of these changes has remained elusive. Structural i
PMID 24434004