WordNet
- matter that remains after something has been removed
- an essential amino acid found in proteins; important for growth in children and nitrogen balance in adults
PrepTutorEJDIC
- 残り,残余;残留物
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- 1. ビタミンＫとγカルボキシグルタミン酸の合成および機能 vitamin k and the synthesis and function of gamma carboxyglutamic acid
- 2. プリオンによる中枢神経系疾患 diseases of the central nervous system caused by prions
- 3. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases
- 4. 成人におけるS状結腸鏡検査および大腸内視鏡検査のための前処置 bowel preparation for colonoscopy and flexible sigmoidoscopy in adults
- 5. 鎌状ヘモグロビン多量体：構造と機能特性 sickle hemoglobin polymer structure and functional properties
English Journal
- A novel presenilin 1 mutation (Ala275Val) as cause of early-onset familial Alzheimer disease.
- Luedecke D1, Becktepe JS1, Lehmbeck JT1, Finckh U2, Yamamoto R2, Jahn H1, Boelmans K3.Author information 1Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.2MVZ Dr. Eberhard & Partner, Dortmund, Germany.3Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: k.boelmans@uke.uni-hamburg.de.AbstractMutations in the presenilin 1 (PS1) gene (PSEN1) are associated with familial Alzheimer disease (FAD). Here, we report on a 50-year-old patient presenting with progressive deterioration of his short-term memory and a family history of early-onset dementia. Diagnostic workup included a neuropsychological examination, structural magnetic resonance (MR) imaging, cerebrospinal fluid (CSF) biomarkers including total tau, phosphorylated tau, and Aβ42 levels, as well as sequencing relevant fragments of the genes PSEN1, PSEN2, and APP. Additionally, we were able to obtain archival paraffin-embedded cerebellar tissue from the patient's father for cosegregation analysis. Clinical, neuropsychological and MR imaging data were indicative of early-onset Alzheimer disease. Furthermore, CSF biomarkers showed a typical pattern for Alzheimer disease. DNA sequencing revealed a heterozygous nucleotide transition (c.824C>T) in exon 8 of PSEN1, leading to an amino acid change from alanine to valine at codon 275 (Ala275Val). The same mutation was found in an archival brain specimen of the patient's demented father, but not in a blood sample of the non-demented mother. This mutation alters a conserved residue in the large hydrophilic loop of PS1, suggesting pathogenic relevance. Cosegregegation analysis and the structural as well as the presumed functional role of the mutated and highly conserved residue suggest FAD causing characteristics of the novel PSEN1 mutation Ala275Val.
- Neuroscience letters.Neurosci Lett.2014 Apr 30;566:115-9. doi: 10.1016/j.neulet.2014.02.034. Epub 2014 Feb 26.
- Mutations in the presenilin 1 (PS1) gene (PSEN1) are associated with familial Alzheimer disease (FAD). Here, we report on a 50-year-old patient presenting with progressive deterioration of his short-term memory and a family history of early-onset dementia. Diagnostic workup included a neuropsycholog
- PMID 24582897
- Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.
- Moskovitz J1, Walss-Bass C2, Cruz DA2, Thompson PM2, Bortolato M1.Author information 1Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, 66045, USA.2Department of Psychiatry, School of Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA.AbstractCatechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individuals. COMT activity is markedly reduced by a non-synonymous single-nucleotide polymorphism (SNP) that generates a valine-to-methionine substitution on the residue 108/158, by means of as-yet incompletely understood post-translational mechanisms. One post-translational modification is methionine sulfoxide, which can be reduced by the methionine sulfoxide reductase (Msr) A and B enzymes. We used recombinant COMT proteins (Val/Met108) and mice (wild-type (WT) and MsrA knockout) to determine the effect of methionine oxidation on COMT activity and COMT interaction with Msr, through a combination of enzymatic activity and Western blot assays. Recombinant COMT activity is positively regulated by MsrA, especially under oxidative conditions, whereas brains of MsrA knockout mice exhibited lower COMT activity (as compared with their WT counterparts). These results suggest that COMT activity may be reduced by methionine oxidation, and point to Msr as a key molecular determinant for the modulation of COMT activity in the brain. The role of Msr in modulating cognitive functions in healthy individuals and schizophrenia patients is yet to be determined.
- The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2014 Apr 15:1-7. [Epub ahead of print]
- Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individ
- PMID 24735585
- Polymer-Peptide delivery platforms: effect of oligopeptide orientation on polymer-based DNA delivery.
- Parelkar SS1, Letteri R, Chan-Seng D, Zolochevska O, Ellis J, Figueiredo M, Emrick T.Author information 1Polymer Science and Engineering Department, University of Massachusetts , 120 Governors Drive, Amherst, Massachusetts 01003, United States.AbstractThe success of nonviral transfection using polymers hinges on efficient nuclear uptake of nucleic acid cargo and overcoming intra- and extracellular barriers. By incorporating PKKKRKV heptapeptide pendent groups as nuclear localization signals (NLS) on a polymer backbone, we demonstrate protein expression levels higher than those obtained from JetPEI and Lipofectamine 2000, the latter being notorious for coupling high transfection efficiency with cytotoxicity. The orientation of the NLS peptide grafts markedly affected transfection performance. Polymers with the sequence attached to the backbone from the valine residue achieved a level of nuclear translocation higher than the levels of those having the NLS groups attached in the opposite orientation. The differences in nuclear localization and DNA complexation strength between the two orientations correlated with a striking difference in protein expression, both in cell culture and in vivo. Polyplexes formed from these comb polymer structures exhibited transfection efficiencies superior to those of Lipofectamine 2000 but with greatly reduced toxicity. Moreover, these novel polymers, when administered by intramuscular ultrasound-mediated delivery, allowed a high level of reporter gene expression in mice, demonstrating their therapeutic promise in vivo.
- Biomacromolecules.Biomacromolecules.2014 Apr 14;15(4):1328-36. doi: 10.1021/bm401878p. Epub 2014 Mar 7.
- The success of nonviral transfection using polymers hinges on efficient nuclear uptake of nucleic acid cargo and overcoming intra- and extracellular barriers. By incorporating PKKKRKV heptapeptide pendent groups as nuclear localization signals (NLS) on a polymer backbone, we demonstrate protein expr
- PMID 24606402
Japanese Journal
- 生命の起源におけるタンパク質ワールド仮説に登場する [GADV]-タンパク質のスレッディングおよびab initioモデリングによる立体構造推定
- 小田 彰史,福吉 修一,中垣 良一
- Journal of Computer Aided Chemistry 14(0), 23-35, 2013
- 生命がタンパク質から生まれたとするタンパク質ワールド仮説の一つに、グリシン・アラニン・アスパラギン酸・バリンのみからなる最初期のタンパク質（[GADV]-タンパク質）から生命が生まれたとするGADV仮説がある。4種の残基しか含まない[GADV]-タンパク質がタンパク質として立体構造を取り得るかを構造生物学的に調査した実験研究は存在せず、またコンピュータによるタンパク質立体構造予測手法についても、通 …
- NAID 130004428037
- Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51
- FEBS Letters 585(12), 1771-1777, 2011-06-23
- … In this study, a mammalian two-hybrid assay and competitive ELISA showed that the interaction between BRC repeat 4 (BRC4) and RAD51 was strengthened by the substitution of a single BRC4 amino acid from valine to isoleucine (V1532I). … This study used a comparative analysis of BRC4 between animal species to identify V1532 as an important residue that interacts with RAD51. …
- NAID 80021826272
- Operational Condition of a Molecular Imprinting Catalyst-based Fructosyl-valine Sensor
- YAMAZAKI Tomohiko,OHTA Shigenori,SODE Koji
- Electrochemistry 76(8), 590-593, 2008
- … We have previously reported the development of an artificial enzyme catalysing hydrolytic oxidation reaction of fructosyl-valine (Fru-val). …
- NAID 130002150740
Related Links
- Übersetzung für valine residue im Englisch-Deutsch-Wörterbuch dict.cc. Alle Sprachen | EN IS IT RU SV FR RO PT HU LA NL SK ES BG HR NO CS TR DA PL EL SR EO | SK HU FR PL | more ... dict.cc Deutsch-Englisch ä ü ß ...
- Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. ... ChEBI The database and ontology of Chemical Entities of Biological Interest
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★リンクテーブル★
| リンク元 | 「Val residue」「バリン残基」 |
| 関連記事 | 「residue」「valine」 |
「Val residue」
「バリン残基」
「residue」
- 関
- residual
「valine」