WordNet

underdevelopment of an organ because of a decrease in the number of cells
of or involving the uterus; "uterine cancer"

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子宮の / 同母異父の

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1. 子宮筋腫と子宮肉腫の識別 differentiating uterine leiomyomas fibroids from uterine sarcomas
2. 婦人科処置時の子宮穿孔 uterine perforation during gynecologic procedures
3. 子宮平滑筋腫（子宮筋腫）の治療の概要 overview of treatment of uterine leiomyomas fibroids
4. 子宮筋腫塞栓術 uterine leiomyoma fibroid embolization
5. 子宮肉腫：分類、臨床症状、および診断 uterine sarcoma classification clinical manifestations and diagnosis

English Journal

Cell cultures in uterine leiomyomas: Rapid disappearance of cells carrying MED12 mutations.

Nadine Markowski D1, Tadayyon M, Bartnitzke S, Belge G, Maria Helmke B, Bullerdiek J.Author information 1Center for Human Genetics, University of Bremen, Leobener Str. ZHG, 28359, Bremen, Germany.AbstractUterine leiomyomas (UL) are the most frequent symptomatic human tumors. Nevertheless, their molecular pathogenesis is not yet fully understood. To learn more about the biology of these common neoplasms and their response to treatment, cell cultures derived from UL are a frequently used model system, but until recently appropriate genetic markers confirming their origin from the tumor cell population were lacking for most UL, i.e., those not displaying karyotypic abnormalities. The identification of MED12 mutations in the majority of UL makes it possible to trace the tumor cell population during in vitro passaging in the absence of cytogenetic abnormalities. The present study is addressing the in vitro survival of cells carrying MED12 mutations and its association with karyotypic alterations. The results challenge numerous in vitro studies into the biology and behavior of leiomyomas. Cells of one genetic subtype of UL, i.e., those with rearrangements of the high mobility AT-hook 2 protein gene (HMGA2), seem to be able to proliferate in vitro for many passages whereas tumor cells from the much more frequent MED12-mutated lesions barely survive even the first passages. Apparently, for the most frequent type of human UL no good in vitro model seems to exist because cells do not survive culturing. On the other hand, this inability may point to an Achilles' heel of this type of UL. © 2014 Wiley Periodicals, Inc.
Genes, chromosomes & cancer.Genes Chromosomes Cancer.2014 Apr;53(4):317-23. doi: 10.1002/gcc.22142. Epub 2014 Jan 21.
Uterine leiomyomas (UL) are the most frequent symptomatic human tumors. Nevertheless, their molecular pathogenesis is not yet fully understood. To learn more about the biology of these common neoplasms and their response to treatment, cell cultures derived from UL are a frequently used model system,
PMID 24446130

Increased IVF pregnancy rates after microarray preimplantation genetic diagnosis due to parental translocations.

Li G1, Jin H, Xin Z, Su Y, Brezina PR, Benner AT, Kearns WG, Sun Y.Author information 1Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University , Zhengzhou , China .AbstractAbstract We successfully performed preimplantation genetic diagnosis (PGD) and simultaneous preimplantation genetic screening (PGS) using single nucleotide polymorphism (SNP) microarrays for couples with balanced chromosome rearrangements in China. A total of 428 molecular karyotypes were diagnosed from 62 couples undergoing 68 in vitro fertilization (IVF) cycles. Of these, 48.1% of the embryos were chromosomally normal without translocation errors or aneuploidy. Of the 428 total embryos, 18.0% embryos were euploid, but were imbalanced due to the transmission of single translocation chromosome derivatives. A total of 6.5% of the embryos had chromosome abnormalities involving the parental chromosome aberration and other chromosomes aneuploidies. Significantly, 27.4% of the embryos were normal/balanced for the rearranged chromosomes, but were abnormal due to aneuploidy affecting other chromosomes. When evaluated on a per IVF cycle basis, 84% of the cycles had at least one chromosomally normal embryo available for uterine transfer. The clinical pregnancy rate per IVF cycle was 54%. Diagnosing genomically balanced embryos through 24 chromosome SNP microarray PGD/PGS, rather than minimally targeted fluorescence in situ hybridization (FISH), is a promising strategy to maximize the pregnancy potential of patients with known parental chromosomal translocations. Moreover, this is the first study to report the clinical application of SNP arrays to screen all 24 chromosome pairs of blastomeres and trophectoderm cells from patients carrying reciprocal translocations in China.
Systems biology in reproductive medicine.Syst Biol Reprod Med.2014 Apr;60(2):119-24. doi: 10.3109/19396368.2013.875241. Epub 2013 Dec 30.
Abstract We successfully performed preimplantation genetic diagnosis (PGD) and simultaneous preimplantation genetic screening (PGS) using single nucleotide polymorphism (SNP) microarrays for couples with balanced chromosome rearrangements in China. A total of 428 molecular karyotypes were diagnosed
PMID 24377704

Genome-wide acquired uniparental disomy as well as chromosomal gains and losses in an uterine epithelioid leiomyoma.

Holzmann C, Markowski DN, Koczan D, Helmke BM, Bullerdiek J.AbstractBACKGROUND: Epitheloid leiomyoma is a rare subtype of benign smooth muscle tumors.
Molecular cytogenetics.Mol Cytogenet.2014 Mar 3;7(1):19. [Epub ahead of print]
BACKGROUND: Epitheloid leiomyoma is a rare subtype of benign smooth muscle tumors.RESULTS: Herein, we present the results of classical cytogenetics, MED12 mutation analysis, and copy number variation array evaluation in one such case. Whereas cytogenetic did not show evidence for clonal chromosome a
PMID 24593849

Japanese Journal

Risk factors for limb reduction defects : review of the epidemiological evidence

Robert Elizabeth
Congenital anomalies 40(supplement), S20-S24, 2000-12-00
NAID 110002785775

ビタミンDレセプターの生体内高次機能

加藤茂明
ビタミン 72(7), 255-261, 1998-07-25
… Consistent with infertility, uterine hypoplasia was found, but such abnormality could not be detected in the male reproductive organs. …
NAID 110002843558