WordNet
- an impairment of health or a condition of abnormal functioning
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
- of or relating to the urinary and reproductive systems
PrepTutorEJDIC
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- 病気にかかった / 病的な,不健全な(morbid)
- 泌尿生殖器の
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- 1. 嚢胞性腎疾患の胎児超音波診断 prenatal sonographic diagnosis of cystic renal disease
- 2. ベーチェット病の臨床症状および診断 clinical manifestations and diagnosis of behcets disease
- 3. 合併症のない淋菌感染の治療 treatment of uncomplicated gonococcal infections
- 4. クラミジア・トラコマティス感染症の臨床症状および診断 clinical manifestations and diagnosis of chlamydia trachomatis infections
- 5. 後部尿道弁の臨床症状および診断 clinical presentation and diagnosis of posterior urethral valves
English Journal
- C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration.
- Tang Y, Huang XR, Lv J1, Chung AC, Zhang Y2, Chen JZ1, Szalai AJ3, Xu A1, Lan HY.Author information 1*Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.2†Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.3§Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, U.S.A.AbstractCRP (C-reactive protein) is regarded as an inflammatory biomarker in AKI (acute kidney injury), but its exact role in AKI remains unclear. Thus we sought to investigate the role of CRP in AKI. Clinically, elevated serum CRP levels were found to associate closely with increased serum creatinine and urea levels (P<0.01) in patients with AKI, which then fell after recovery from AKI. To determine the role of CRP in AKI, an ischaemia/reperfusion mouse model of AKI was developed using Tg (transgenic) mice that express human CRP. Compared with the WT (wild-type) mice, CRP Tg mice developed more severe renal injury at 24 h after ischaemia as determined by significantly increased serum creatinine and tubular necrosis. This was associated with an impaired TEC (tubular epithelium cell) regeneration as shown by an over 60% reduction in PCNA+ (proliferating-cell nuclear antigen) and BrdU+ (bromodeoxyuridine) TECs in CRP Tg mice with AKI. In vitro, the addition of CRP to a human TEC line (HK-2) also largely suppressed the proliferation of TECs. The functional role of CRP in AKI was demonstrated further by the blocking of CRP binding to the FcγRII (Fcγ receptor II) with a neutralizing anti-CD32 antibody, which restored TEC proliferation and prevented AKI in CRP Tg mice. Moreover, we found that impaired G1/S transition by suppression of the phosphorylation of CDK2 (cyclin-dependent kinase 2) and expression of cyclin E may be a key mechanism by which CRP inhibits TEC regeneration during the AKI repair process. In conclusion, CRP plays a pathogenic role in AKI by inhibiting G1/S-dependent TEC regeneration. The results of the present study suggest that targeting CRP signalling may offer a new therapeutic potential for AKI.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 May;126(9):645-59. doi: 10.1042/CS20130471.
- CRP (C-reactive protein) is regarded as an inflammatory biomarker in AKI (acute kidney injury), but its exact role in AKI remains unclear. Thus we sought to investigate the role of CRP in AKI. Clinically, elevated serum CRP levels were found to associate closely with increased serum creatinine and u
- PMID 24206243
- Gonococcal endocarditis: a case report and review of the literature.
- Ramos A1, García-Pavía P, Orden B, Cobo M, Sánchez-Castilla M, Sánchez-Romero I, Múñez E, Marín M, García-Montero C.Author information 1Department of Internal Medicine (Infectious Diseases Unit), Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Maestro Rodrigo 2, Majadahonda, 28220, Madrid, Spain, aramos220@gmail.com.AbstractA 59-year-old Caucasian male presented with progressive dyspnea, arthralgias and fever for three days. A diastolic regurgitation murmur was detected in the aortic area. A transesophageal echocardiograph showed several vegetations and severe aortic regurgitation. Blood cultures yielded Neisseria gonorrhoeae beta-lactamase negative. The patient had not noticed any urogenital discomfort or urethral discharge. The patient successfully underwent surgery for septal abscess debridement. The patient received ceftriaxone 2 g bid for eight weeks and the clinical follow-up was uneventful. The review of the literature revealed a total of the 38 additional cases reported between 1980 and the present. The majority of the patients were young, male and with native valve involvement. There has been a clear tendency for left-sided valve involvement (especially in the aortic valve). All valve cultures were reported negative despite, in most cases, the marked tissue destruction. Polymerase chain reaction was performed in two patients and positive results were shown in both. Cultures of exudates from other locations were negative in most cases. One striking fact is the high proportion of patients who underwent surgery (72 %). Information regarding antibiotic sensitivity was available in 28 cases, with penicillin resistance reported in six patients (21 %) and intermediate sensitivity in four patients (14 %). Resistance to ciprofloxacin was reported in two cases (7 %). A rapid increase and distribution of isolates resistant to third generation cephalosporins have been recently detected. The mortality is high, particularly taking into account that most were young patients who had not presented previous heart disease.
- Infection.Infection.2014 Apr;42(2):425-8. doi: 10.1007/s15010-013-0541-9. Epub 2013 Oct 27.
- A 59-year-old Caucasian male presented with progressive dyspnea, arthralgias and fever for three days. A diastolic regurgitation murmur was detected in the aortic area. A transesophageal echocardiograph showed several vegetations and severe aortic regurgitation. Blood cultures yielded Neisseria gon
- PMID 24163221
- Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species.
- Anderson M1, Roshanravan H, Khine J, Dryer SE.Author information 1Department of Biology and Biochemistry, University of Houston, Houston, Texas.AbstractAngiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS) in podocytes. Canonical transient receptor potential-6 (TRPC6) channels stimulate Ca(2+) influx in podocytes, and have been implicated in glomerular disease. We observed that AII increased cationic currents in rat podocytes in an isolated glomerulus preparation in which podocytes are still attached to the underlying capillary. This effect was completely blocked by SKF-96365, by micromolar La(3+) , and by siRNA knockdown of TRPC6, indicating that TRPC6 is the primary source of Ca(2+) influx mobilized by endogenously expressed angiotensin II receptors in these cells. These responses were also blocked by the AT1R antagonist losartan, the phospholipase C inhibitor D-609, and by inhibition of G protein signaling. The pan-protein kinase C inhibitor chelerythrine had no effect. Importantly, pretreating podocytes with the ROS quencher manganese (III) tetrakis (4-benzoic acid) porphyrin chloride (MnTBAP) eliminated AII activation of TRPC6. Significant reductions of AII effects on podocyte TRPC6 were also observed after pretreatment with NADPH oxidase inhibitors apocynin or diphenylene iodonium (DPI). These data suggest that ROS production permits activation of TRPC6 channels by G protein and PLC-dependent cascades initiated by AII acting on AT1Rs in podocytes. This pathway also provides a basis whereby two forms of cellular stress-oxidative stress and Ca(2+) overload-converge on common pathways relevant to disease.
- Journal of cellular physiology.J Cell Physiol.2014 Apr;229(4):434-42. doi: 10.1002/jcp.24461.
- Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS) in podocytes. Canonical transient
- PMID 24037962
Japanese Journal
- 複雑性尿路感染症を合併したMODY5の1例
- 青木 絵麻,滝澤 美保,柳沢 慶香,原田 真耶,花井 豪,石井 晶子,家後 理枝,岩崎 直子,岩本 安彦,AOKI Ema,TAKIZAWA Miho,YANAGISAWA Keiko,HARADA Maya,HANAI Ko,ISHII Akiko,YAGO Rie,IWASAKI Naoko,IWAMOTO Yasuhiko
- 東京女子医科大学雑誌 81(E2), E247-E252, 2011-03-31
- 症例は50歳、女性。25歳時糖尿病と診断されインスリン療法を開始された。その際に左腎萎縮と両腎嚢胞を指摘された。糖尿病診断当初インスリン分泌能は保たれており、治療開始後1年から3年の間は一時的に経口血糖降下薬で血糖コントロール可能であったが、徐々に内因性インスリン分泌は低下し、現在はほぼ枯渇している。母親に糖尿病、姉に耐糖能障害を認め,両腎嚢胞とインスリン分泌不全などの特徴から臨床的にMODY5が …
- NAID 110008441476
- IPO-05 Patchy innervation in pull-through bowel of Hirschsprung's disease(Intestinal tract/Hernia,Share Smiles with Sick Children, Dreams and Innovation for Pediatric Surgery)
- Takahashi Tsubasa,Kato Yoshifumi,Okazaki Tadaharu,Koga Hiroyuki,Lane Geoffrey,Yamataka Atsuyuki
- 日本小児外科学会雑誌 46(3), 487, 2010-05-20
- NAID 110008015834
- 牛の腸閉鎖の解剖学的検討
- 村上 隆之,Murakami Takayuki,ムラカミ タカユキ
- 日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 61(8), 613-616, 2008-08-20
- … Ninety-nine of 114 (86.84%) calves showing anorectal anomalies had associated defects including fistula to the urogenital tract in 44, other deformities of the urogenital system in 49, congenital cardiac disease in 43 and spinal abnormalities in 34 calves. …
- NAID 10025574415
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- urogenital disease - also known as or related to syndrome of the genitourinary system, disease of the genitourinary system (disorder), urogenital disorder, disease of the genitourinary system, disorder of the genitourinary system ...
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★リンクテーブル★
| リンク元 | 「泌尿生殖器疾患」 |
| 拡張検索 | 「female urogenital diseases and pregnancy complications」「female urogenital disease」「male urogenital disease」 |
| 関連記事 | 「disease」「urogenital」 |
「泌尿生殖器疾患」
「female urogenital diseases and pregnancy complications」
「female urogenital disease」
「male urogenital disease」
「disease」
- n.
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 注意
「urogenital」
- adj.
- 泌尿生殖器の