尿酸塩腎症
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
- in or relating to or obtained from urine; "uric acid"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
- 尿の,尿に関する(含まれている),尿から得られる
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/30 16:41:23」(JST)
[Wiki en表示]
Acute uric acid nephropathy (AUAN, also acute urate nephropathy) is a rapidly worsening (decreasing) kidney function (renal insufficiency) that is caused by high levels of uric acid in the urine (hyperuricosuria).
Contents
- 1 Causes
- 2 Pathophysiology
- 3 Diagnosis
- 4 Prevention
- 5 Treatment
- 6 References
Causes
Acute uric acid nephropathy is usually seen as part of the acute tumour lysis syndrome in patients undergoing chemotherapy or radiation therapy for the treatment of malignancies with rapid cell turnover, such as leukemia and lymphoma. It may also occur in these patients before treatment is begun, due to spontaneous tumor cell lysis (high incidence in Burkitt's lymphoma).
Acute uric acid nephropathy can also be caused by an acute attack of gout.
Pathophysiology
Acute uric acid nephropathy is caused by deposition of uric acid crystals within the kidney interstitium and tubules, leading to partial or complete obstruction of collecting ducts, renal pelvis, or ureter. This obstruction is usually bilateral, and patients follow the clinical course of acute renal failure.
Diagnosis
The picture of acute renal failure is observed: decreased urine production and rapidly rising serum creatinine levels. Acute uric acid nephropathy is differentiated from other forms of acute renal failure by the finding of a urine uric acid/creatinine ratio > 1 in a random urine sample.
Prevention
Patients at risk for acute uric acid nephropathy can be given allopurinol or rasburicase (a recombinant urate oxidase) prior to treatment with cytotoxic drugs.
Treatment
Treatment is focused on preventing deposition of uric acid within the urinary system by increasing urine volume with potent diuretics such as furosemide. Raising the urinary pH to a level higher than 7 (alkalinization) is often difficult to attain, although sodium bicarbonate and/or acetazolamide are sometimes used in an attempt to increase uric acid solubility.
Dialysis (preferably hemodialysis) is started if the above measures fail.
References
- Conger JD (1990). "Acute uric acid nephropathy". Med Clin North Am 74 (4): 859–71. PMID 2195258.
- Robinson RR, Yarger WE (1977). "Acute uric acid nephropathy". Arch Intern Med 137 (7): 839–40. doi:10.1001/archinte.137.7.839. PMID 879920.
- Yu ASL, Brenner BM (2005). "Chapter 266: Tubulointerstitial diseases of the kidney". In Kasper DL, Braunwald E, Fauci A, Hauser S, Longo D, Jameson JL. Harrison's Principles of Internal Medicine (16th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-140235-4
UpToDate Contents
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English Journal
- Astaxanthin from shrimp by-products ameliorates nephropathy in diabetic rats.
- Sila A1, Ghlissi Z, Kamoun Z, Makni M, Nasri M, Bougatef A, Sahnoun Z.
- European journal of nutrition.Eur J Nutr.2015 Mar;54(2):301-7. doi: 10.1007/s00394-014-0711-2. Epub 2014 May 13.
- AIM: This study investigated the hypoglycemic and antioxidant effects of shrimp astaxanthin on the kidney of alloxan-induced diabetic rats.METHODS: Animals were distributed into four groups of six rats each: a control group (C), a diabetic group (D), a diabetic group supplemented with Astaxanthin (D
- PMID 24821271
- Association between red blood cell distribution and renal function in patients with untreated type 2 diabetes mellitus.
- Zhang M1, Zhang Y, Li C, He L.
- Renal failure.Ren Fail.2015 Feb 16:1-5. [Epub ahead of print]
- Abstract We assessed whether red cell distribution width (RDW) is associated with microalbuminuria (MAU) in a group of 320 patients with newly diagnosed type 2 diabetes mellitus (T2DM), recruited in Zhengzhou. Patients were divided into normal group and MAU group. Compared with the normal group, the
- PMID 25682974
- The molecular physiology of uric Acid homeostasis.
- Mandal AK1, Mount DB.
- Annual review of physiology.Annu Rev Physiol.2015 Feb 10;77:323-45. doi: 10.1146/annurev-physiol-021113-170343. Epub 2014 Nov 12.
- Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Serum uric acid is determined by production and the net balance of reabsorption or secretion by the kidney and intestine. A detailed understanding of epithelial absorption and secretion of uric acid
- PMID 25422986
Japanese Journal
- Uromodulin (UMOD) に新規変異を認めた家族性若年性高尿酸血症性腎症の父子例
- 内科診療所での糖尿病腎症患者に対する行動医学チーム医療に臨床心理士を加える試み
- High Salt Intake is Associated with Renal Involvement in Japanese Patients with Type 2 Diabetes Mellitus
Related Links
- Uric acid is the relatively water-insoluble end product of purine nucleotide metabolism. It poses a special problem for humans because of its limited solubility, particularly in the acidic environment of the distal nephron of the kidney. [1] It is problematic because humans do not possess the enzyme ...
- Definition of uric acid nephropathy in the Medical Dictionary. uric acid nephropathy explanation. Information about uric acid nephropathy in Free online English dictionary. What is uric acid nephropathy? Meaning of uric acid forum ...
Related Pictures
★リンクテーブル★
[★]
- 英
- gouty nephropathy, gouty kidney
- 同
- 尿酸塩腎症 urate nephropathy、高尿酸血性腎症 hyperuricemic nephropathy、痛風性腎症、尿酸性腎症 uric acid nephropathy
- 関
- 高尿酸血症
- 高尿酸血症による腎障害
- 尿細管障害をきたす。
- 病理的には間質に尿酸や尿酸一ナトリウム塩の結晶の存在が確認される。これにより間質の閉塞だけでなく炎症反応を惹起する。リンパ球の浸潤、foreign-body giant cell reaction、ついには線維化をきたす。これは腎髄質や腎乳頭で著明である。 (HIM.1809)
- GFRはほぼ正常。脳濃縮能の低下、(蛋白尿?) (HIM.1809)
[★]
- 英
- uric acid nephropathy、urate nephropathy
- 関
- 尿酸塩腎症
[★]
- 関
- urate、uric acid